| Chemical & Physical Properties | |
|---|---|
| CAS Number | 70588-05-5 |
| Catalog No. | 2A-9047188 |
| Chinese Name | 决明素 |
| Synonyms | 1,7-dihydroxy-2,3,8-trimethoxy-6-methylanthracene-9,10-dione; 1,7-Dihydroxy-2,3,8-trimethoxy-6-methyl-9,10-anthraquinone |
| Molecular Formula | C18H16O7 |
| Molecular Weight | 344.32 |
| Purity | 98.00 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 614.9±55.0 °C at 760 mmHg |
| Storage Condition | 2-8℃ |
| Application | Obtusin, derived from cassia seeds, is a highly selective and competitive inhibitor of human monoamine oxidase-A (hMAO-A) with an IC50 of 11.12 μM and a Ki of 6.15. Obtusin plays a preventive role in |
| HTC | 2914690090 |
| PubChem ID | 24513172 |
| MDL Number | MFCD13195592 |
| SMILES | COc1cc2c(c(O)c1OC)C(=O)c1c(cc(C)c(O)c1OC)C2=O |
| InChI | InChI=1S/C18H16O7/c1-7-5-8-12(18(25-4)13(7)19)15(21)11-9(14(8)20)6-10(23-2)17(24-3)16(11)22/h5-6,19,22H,1-4H3 |
| InChI Key | CFLNHFUPWNRWJA-UHFFFAOYSA-N |
| MSDS | msds/47188_1_70588_05_5.pdf |
| Use of | Obtusin, isolated from Cassia obtusifolia Linn seed, is a highly selective and competitive human monoamine oxidase-A (hMAO-A) inhibitor with an IC50 of 11.12 μM and a Ki of 6.15. Obtusin plays a preventive role in neurodegenerative diseases, especially anxiety and depression[1]. Properties Name Obtusin Synonym More Synonyms Obtusin Biological Activity Description Obtusin, isolated from Cassia obtusifolia Linn seed, is a highly selective and competitive human monoamine oxidase-A (hMAO-A) inhibitor with an IC50 of 11.12 μM and a Ki of 6.15. Obtusin plays a preventive role in neurodegenerative diseases, especially anxiety and depression[1]. Related Catalog Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Neurological Disease IC50: 11.12 μM (hMAO-A)[1] Ki: 6.15 (hMAO-A)[1] References [1]. Paudel P, et al. In Vitro and in Silico Human Monoamine Oxidase Inhibitory Potential of Anthraquinones, Naphthopyrones, and Naphthalenic Lactones from Cassia obtusifolia Linn Seeds. ACS Omega. 2019 Sep 18;4(14):16139-16152. Chemical & Physical Properties Molecular Formula C18H16O7 Exact Mass 344.089600 PSA 102.29000 Index of Refraction 1.634 InChIKey CFLNHFUPWNRWJA-UHFFFAOYSA-N Storage condition 2-8℃ Safety Information HS Code 2914690090 Synthetic Route Total: 1 Page 1-Methoxy-3-met... CAS#:108637-73-6 5-hydroxy-6,7-d... CAS#:108637-94-1 CAS#:70588-05-5 Literature: Cameron, Donald W.; Feutrill, Geoffrey I.; Gamble, Glenn B.; Stavrakis, John Tetrahedron Letters, 1986 , vol. 27, # 41 p. 4999 - 5002 Precursor & DownStream Precursor 2 CAS#:108637-73-6 1-Methoxy-3-met... CAS#:108637-94-1 5-hydroxy-6,7-d... DownStream 0 |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 5.5% Ordinary tariff: 30.0% |
| Transport Info | Product name: Cassia |
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