![2,2-Bis[4-(4-aminophenoxy)phenyl]hexafluoropropane structure, CAS 69563-88-8](/structures/60000/47038_1_69563_88_8.png)
CAS Number69563-88-8
Synonyms2,2-bis(4-[4-aminophenoxy]phenyl)hexafluoropropane; 2,2-bis[4-(p-aminophenoxy)phenyl]hexafluoropropane; 4,4'-[(1,1,1,3,3,3-Hexafluoro-2,2-propanediyl)bis(4,1-phenyleneoxy)]dianiline; 2,2-bis[4-(4'-aminophenoxy)phenyl]-1,1,1,3,3,3-hexafluoropropane; 2,2-bis[4-(4-aminophenoxy)-phenyl]hexafluoropropane; 4,4'-[(1,1,1,3,3,3-hexafluoropropane-2,2-diyl)bis(benzene-4,1-diyloxy)]dianiline; HFBAPP; MFCD00015723; [1,1-bis(trifluoromethyl)-1,1-bis(4-(4-amino-phenoxy)-phenyl)]methane; 1,1,1,3,3,3-hexafluoro-2,2-bis[4-(4-aminophenoxy)phenyl]propane; isbenzenamine; 2,2'-BIS[4-(4-AMINOPHENOXY)PHENY]HEXAFLUOROPROPANE; BAPOFP; BIS-AF-A; 4-BDAF; leneoxy))bis; 4',4'''-(Hexafluoroisopropylidene)-bis-(4-phenoxyaniline); 4,4'-[(1,1,1,3,3,3-Hexafluoropropane-2,2-diyl)bis(4,1-phenyleneoxy)]dianiline; 2,2-BIS[4-(4-
Molecular Formula(CF3)2C(C6H4OC6H4NH2)2
Molecular Weight518.45
Purity97%
Density1.4±0.1 g/cm3
Boiling Point544.8±50.0 °C at 760 mmHg
Melting Point159-163 °C (lit.)
Appearancewhite crystal
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 69563-88-8 |
| Catalog No. | 2A-9047038 |
| Chinese Name | 2,2-双[4-(4-氨基苯氧基苯)]六氟丙烷 |
| Synonyms | 2,2-bis(4-[4-aminophenoxy]phenyl)hexafluoropropane; 2,2-bis[4-(p-aminophenoxy)phenyl]hexafluoropropane; 4,4'-[(1,1,1,3,3,3-Hexafluoro-2,2-propanediyl)bis(4,1-phenyleneoxy)]dianiline; 2,2-bis[4-(4'-aminophenoxy)phenyl]-1,1,1,3,3,3-hexafluoropropane; 2,2-bis[4-(4-aminophenoxy)-phenyl]hexafluoropropane; 4,4'-[(1,1,1,3,3,3-hexafluoropropane-2,2-diyl)bis(benzene-4,1-diyloxy)]dianiline; HFBAPP; MFCD00015723; [1,1-bis(trifluoromethyl)-1,1-bis(4-(4-amino-phenoxy)-phenyl)]methane; 1,1,1,3,3,3-hexafluoro-2,2-bis[4-(4-aminophenoxy)phenyl]propane; isbenzenamine; 2,2'-BIS[4-(4-AMINOPHENOXY)PHENY]HEXAFLUOROPROPANE; BAPOFP; BIS-AF-A; 4-BDAF; leneoxy))bis; 4',4'''-(Hexafluoroisopropylidene)-bis-(4-phenoxyaniline); 4,4'-[(1,1,1,3,3,3-Hexafluoropropane-2,2-diyl)bis(4,1-phenyleneoxy)]dianiline; 2,2-BIS[4-(4- |
| Molecular Formula | (CF3)2C(C6H4OC6H4NH2)2 |
| Molecular Weight | 518.45 |
| Purity | 97 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 544.8±50.0 °C at 760 mmHg |
| Melting Point | 159-163 °C (lit.) |
| Appearance | white crystal |
| Storage Condition | Store in an airtight container in a cool, dry plac |
| Application | GI-530159 is a selective TREK1 (K2P2.1) and TREK2 (K2P10.1) channel opener with an EC50 of 0.76 μM for TREK1. GI-530159 demonstrates TREK1/2 selectivity for TRAAK, TASK3 and other potassium channels. |
| HTC | 2922299090 |
| PubChem ID | 24864109 |
| MDL Number | MFCD00015723 |
| SMILES | NC(C=C1)=CC=C1OC(C=C2)=CC=C2C(C(F)(F)F)(C(F)(F)F)C3=CC=C(OC4=CC=C(N)C=C4)C=C3 |
| InChI | 1S/C27H20F6N2O2/c28-26(29,30)25(27(31,32)33,17-1-9-21(10-2-17)36-23-13-5-19(34)6-14-23)18-3-11-22(12-4-18)37-24-15-7-20(35)8-16-24/h1-16H,34-35H2 |
| InChI Key | HHLMWQDRYZAENA-UHFFFAOYSA-N |
| NACRES Code | NA.23 |
| UNSPSC | 12162002 |
| Hazard Symbols | transportation |
| MSDS | msds/47038_1_69563_88_8.pdf |
| Bioactivity | GI-530159 is a selective, mechanosensitive opener of TREK1 (K2P2.1) and TREK2 (K2P10.1) channels, with an EC50 of 0.76 μM for TREK1. GI-530159 displays selectivity for TREK1/2 over TRAAK, TASK3 and other potassium channels. GI-530159 reduces rat dorsal root ganglion neuron excitability[1]. Related Catalog Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel References [1]. Loucif AJC, et al. GI-530159, a novel, selective, mechanosensitive two-pore-domain potassium (K2P ) channel opener, reduces rat dorsal root ganglion neuron excitability. Br J Pharmacol. 2018;175(12):2272-2283. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 544.8±50.0 °C at 760 mmHg Melting Point 159-163 °C(lit.) Molecular Formula C27H20F6N2O2 Molecular Weight 518.450 Flash Point 283.3±30.1 °C Exact Mass 518.142883 PSA 70.50000 LogP 4.57 Vapour Pressure 0.0±1.5 mmHg at 25°C Index of Refraction 1.579 InChIKey HHLMWQDRYZAENA-UHFFFAOYSA-N SMILES Nc1ccc(Oc2ccc(C(c3ccc(Oc4ccc(N)cc4)cc3)(C(F)(F)F)C(F)(F)F)cc2)cc1 |
| Use of | Properties Name 2,2-bis[4-(4-aminophenoxy)phenyl]hexafluoropropane Synonym More Synonyms GI-530159 Biological Activity Related Catalog Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel References [1]. Loucif AJC, et al. GI-530159, a novel, selective, mechanosensitive two-pore-domain potassium (K2P ) channel opener, reduces rat dorsal root ganglion neuron excitability. Br J Pharmacol. 2018;175(12):2272-2283. Chemical & Physical Properties Molecular Formula C27H20F6N2O2 Exact Mass 518.142883 PSA 70.50000 Index of Refraction 1.579 InChIKey HHLMWQDRYZAENA-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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