CAS Number69308-37-8
Synonyms(R)-(-)-Baclofen; (βR)-β-(Aminomethyl)-4-chlorobenzenepropanoic acid; Z1YR DG&1VQ &&(R)-(-)- Form; (-)-Baclofen; (R)-(-)-4-Amino-3-(4-chlorophenyl)butanoic acid; (3R)-4-Amino-3-(4-chlorophenyl)butyric acid; (3R)-4-Amino-3-(4-chlorophenyl)butanoic acid; (R)-Baclofen; (R)-4-Amino-3-(4-chlorophenyl)butanoic acid; Arbaclofen; MFCD01321057; (R)-(-)-4-Amino-3-(4-chlorophenyl)butyric acid
Molecular FormulaC10H12ClNO2
Molecular Weight250.12
Purity98.00%
Density1.3±0.1 g/cm3
Boiling Point364.3±32.0 °C at 760 mmHg
Melting Point171-174°C
Appearancesolid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 69308-37-8 |
| Catalog No. | 2A-9047000 |
| Chinese Name | (R)-巴氯芬(mM/ml) |
| Synonyms | (R)-(-)-Baclofen; (βR)-β-(Aminomethyl)-4-chlorobenzenepropanoic acid; Z1YR DG&1VQ &&(R)-(-)- Form; (-)-Baclofen; (R)-(-)-4-Amino-3-(4-chlorophenyl)butanoic acid; (3R)-4-Amino-3-(4-chlorophenyl)butyric acid; (3R)-4-Amino-3-(4-chlorophenyl)butanoic acid; (R)-Baclofen; (R)-4-Amino-3-(4-chlorophenyl)butanoic acid; Arbaclofen; MFCD01321057; (R)-(-)-4-Amino-3-(4-chlorophenyl)butyric acid |
| Molecular Formula | C10H12ClNO2 |
| Molecular Weight | 250.12 |
| Purity | 98.00 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 364.3±32.0 °C at 760 mmHg |
| Melting Point | 171-174°C |
| Appearance | solid |
| Storage Condition | Store at RT |
| Application | (R)-Baclofen (STX209) is a selective GABAB receptor agonist. |
| PubChem ID | 24895006 |
| MDL Number | MFCD00078579 |
| SMILES | Cl[H].NC[C@H](CC(O)=O)c1ccc(Cl)cc1 |
| InChI | 1S/C10H12ClNO2.ClH/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14;/h1-4,8H,5-6,12H2,(H,13,14);1H/t8-;/m0./s1 |
| InChI Key | WMNUVYYLMCMHLU-QRPNPIFTSA-N |
| NACRES Code | NA.32 |
| UNSPSC | 12352200 |
| MSDS | msds/47000_1_69308_37_8.pdf |
| Bioactivity | (R)-Baclofen(STX209) is a selective GABAB receptor agonist. IC50 value:Target: GABAB receptorGABAB receptors are metabotropic receptors which produce slow inhibitory signals. By manipulating GABAB receptor activity using Baclofen, a variety of functions are studied including synaptic transmissions and antinociception events. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor Research Areas >> Neurological Disease References [1]. Falch E, Hedegaard A, Nielsen L et al. Comparative stereostructure-activity studies on GABAA and GABAB receptor sites and GABA uptake using rat brain membrane preparations. J Neurochem. 1986 Sep;47(3):898-903. [2]. Hong YG, Henry JL. Effects of phaclofen and the enantiomers of baclofen on cardiovascular responses to intrathecal administration of L- and D-baclofen in the rat. Eur J Pharmacol. 1991 Apr 24;196(3):267-75. [3]. Orsnes G, Crone C, Krarup C et al. The effect of baclofen on the transmission in spinal pathways in spastic multiple sclerosis patients. Clin Neurophysiol. 2000 Aug;111(8):1372-9. [4]. Colombo G, Addolorato G, Agabio R et al. Role of GABA(B) receptor in alcohol dependence: reducing effect of baclofen on alcohol intake and alcohol motivational properties in rats and amelioration of alcohol withdrawal syndrome and alcohol craving in human alcoholics. Neurotox Res. 2004;6(5):403-14. [5]. Stetkarova I, Yablon SA, Kofler M, Stokic DS. Procedure- and device-related complications of intrathecal baclofen administration for management of adult muscle hypertonia: a review. Neurorehabil Neural Repair. 2010 Sep;24(7):609-19. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 364.3±32.0 °C at 760 mmHg Melting Point 171-174°C Molecular Formula C10H12ClNO2 Molecular Weight 213.661 Flash Point 174.1±25.1 °C Exact Mass 213.055649 PSA 63.32000 LogP 1.56 Vapour Pressure 0.0±0.9 mmHg at 25°C Index of Refraction 1.577 InChIKey KPYSYYIEGFHWSV-QMMMGPOBSA-N SMILES NCC(CC(=O)O)c1ccc(Cl)cc1 Storage condition Store at RT |
| Use of | (R)-Baclofen(STX209) is a selective GABAB receptor agonist. IC50 value:Target: GABAB receptorGABAB receptors are metabotropic receptors which produce slow inhibitory signals. By manipulating GABAB receptor activity using Baclofen, a variety of functions are studied including synaptic transmissions and antinociception events. Properties Name (R)-4-Amino-3-(4-chlorophenyl)butanoic acid Synonym More Synonyms (R)-Baclofen Biological Activity Description (R)-Baclofen(STX209) is a selective GABAB receptor agonist. IC50 value:Target: GABAB receptorGABAB receptors are metabotropic receptors which produce slow inhibitory signals. By manipulating GABAB receptor activity using Baclofen, a variety of functions are studied including synaptic transmissions and antinociception events. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor Research Areas >> Neurological Disease References [2]. Hong YG, Henry JL. Effects of phaclofen and the enantiomers of baclofen on cardiovascular responses to intrathecal administration of L- and D-baclofen in the rat. Eur J Pharmacol. 1991 Apr 24;196(3):267-75. [3]. Orsnes G, Crone C, Krarup C et al. The effect of baclofen on the transmission in spinal pathways in spastic multiple sclerosis patients. Clin Neurophysiol. 2000 Aug;111(8):1372-9. [4]. Colombo G, Addolorato G, Agabio R et al. Role of GABA(B) receptor in alcohol dependence: reducing effect of baclofen on alcohol intake and alcohol motivational properties in rats and amelioration of alcohol withdrawal syndrome and alcohol craving in human alcoholics. Neurotox Res. 2004;6(5):403-14. [5]. Stetkarova I, Yablon SA, Kofler M, Stokic DS. Procedure- and device-related complications of intrathecal baclofen administration for management of adult muscle hypertonia: a review. Neurorehabil Neural Repair. 2010 Sep;24(7):609-19. Chemical & Physical Properties Exact Mass 213.055649 PSA 63.32000 Index of Refraction 1.577 InChIKey KPYSYYIEGFHWSV-QMMMGPOBSA-N Storage condition Store at RT |
| Transport Info | Product name: (R)-Baclofen |
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