CAS Number69123-94-0
Synonyms1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-2,4(1H,3H)-pyrimidinedione; 2'-Deoxy-2'-fluorouridine; 1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)pyrimidine-2,4(1H,3H)-dione; 2'-Fluoro-2'-deoxyuridine; 1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione; 1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)uracil
Molecular FormulaC9H11O5N2F1
Molecular Weight246.2
Purity98.00%
Density1.6±0.1 g/cm3
Appearancecolorless solid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 69123-94-0 |
| Catalog No. | 2A-9046972 |
| Chinese Name | 1-(2-脱氧-2-氟-β-D-阿拉伯呋喃糖)尿嘧啶 |
| Synonyms | 1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-2,4(1H,3H)-pyrimidinedione; 2'-Deoxy-2'-fluorouridine; 1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)pyrimidine-2,4(1H,3H)-dione; 2'-Fluoro-2'-deoxyuridine; 1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione; 1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)uracil |
| Molecular Formula | C9H11O5N2F1 |
| Molecular Weight | 246.2 |
| Purity | 98.00 |
| Density | 1.6±0.1 g/cm3 |
| Appearance | colorless solid |
| Storage Condition | 2-8°C |
| Application | 1-(2-Deoxy-2-fluoro-β-D-arabinofuryl)uracil is a purine nucleoside analog. Purine nucleoside analogues have broad antitumor activity and target indolent lymphoid malignancies. The anti-cancer mechanis |
| HTC | 2934999090 |
| PubChem ID | 3719653 |
| MDL Number | MFCD00870798 |
| SMILES | O=c1ccn(C2OC(CO)C(O)C2F)c(=O)[nH]1 |
| InChI | InChI=1S/C9H11FN2O5/c10-6-7(15)4(3-13)17-8(6)12-2-1-5(14)11-9(12)16/h1-2,4,6-8,13,15H,3H2,(H,11,14,16)/t4-,6+,7-,8-/m1/s1 |
| InChI Key | UIYWFOZZIZEEKJ-PXBUCIJWSA-N |
| MSDS | msds/46972_1_69123_94_0.pdf |
| Use of | 1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. Properties Name 1-(2-Deoxy-2-fluoro-b-D-arabinofuranosyl)uracil Synonym More Synonyms 2'-Deoxy-2'-fluorouridine Biological Activity Description 1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. Related Catalog Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog Research Areas >> Others References [1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. Chemical & Physical Properties Molecular Formula C9H11FN2O5 Exact Mass 246.065201 PSA 104.55000 LogP -1.31 Index of Refraction 1.608 InChIKey UIYWFOZZIZEEKJ-PXBUCIJWSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Uracil, 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)- CAS REGISTRY NUMBER : 69123-94-0 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C11-H15-F-N2-O5 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : T6NVMVJ E2 A- BT5OTJ CF DQ E1Q HEALTH HAZARD DATA ACUTE TOXICITY DATA MUTATION DATA TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Rodent - rat Bone marrow DOSE/DURATION : 3700 umol/L REFERENCE : PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954- Volume(issue)/page/year: 26,333,1985 Safety Information HS Code 2934999090 Precursor & DownStream Precursor 0 DownStream 2 CAS#:66-22-8 CAS#:122757-52-2 1-[(2R,5S)-3-Fl... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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