CAS Number68767-14-6
SynonymsIOXOPROFEN; MFCD00864331; KOLOXO; 2-{4-[(2-Oxocyclopentyl)methyl]phenyl}propanoic acid; Loxoprofen
Molecular FormulaC15H18O3
Molecular Weight246.30
Purity98.00%
Density1.2±0.1 g/cm3
Boiling Point417.9±20.0 °C at 760 mmHg
Melting Point108.5 - 111ºC
Appearancesolid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 68767-14-6 |
| Catalog No. | 2A-9046886 |
| Chinese Name | 洛索洛芬 |
| Synonyms | IOXOPROFEN; MFCD00864331; KOLOXO; 2-{4-[(2-Oxocyclopentyl)methyl]phenyl}propanoic acid; Loxoprofen |
| Molecular Formula | C15H18O3 |
| Molecular Weight | 246.30 |
| Purity | 98.00 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 417.9±20.0 °C at 760 mmHg |
| Melting Point | 108.5 - 111ºC |
| Appearance | solid |
| Water Solubility | Soluble in: methanol |
| Storage Condition | room temperature |
| Application | Loxoprofen is a non-steroidal anti-inflammatory compound. |
| HTC | 2918300090 |
| PubChem ID | 24278509 |
| MDL Number | MFCD00864331 |
| SMILES | CC(C(O)=O)c1ccc(CC2CCCC2=O)cc1 |
| InChI | 1S/C15H18O3/c1-10(15(17)18)12-7-5-11(6-8-12)9-13-3-2-4-14(13)16/h5-8,10,13H,2-4,9H2,1H3,(H,17,18) |
| InChI Key | YMBXTVYHTMGZDW-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | transportation |
| Bioactivity | Loxoprofen is a non-steroidal anti-inflammatory drug.Target: COXLoxoprofen is a non-steroidal anti-inflammatory drug in the propionic acid derivatives group, which also includes ibuprofen and naproxen among others. Loxoprofen is a non-selective cyclooxygenase inhibitor, and works by reducing the synthesis of prostaglandins from arachidonic acid. Related Catalog Research Areas >> Inflammation/Immunology Target COX-1:6.5 μM (IC50, in human whole blood) COX-2:13.5 μM (IC50, in human whole blood) References [1]. Riendeau D, et al. Evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2. Bioorg Med Chem Lett. 2004 Mar 8;14(5):1201-3. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 417.9±20.0 °C at 760 mmHg Melting Point 108.5 - 111ºC Molecular Formula C15H18O3 Molecular Weight 246.302 Flash Point 220.7±18.3 °C Exact Mass 246.125595 PSA 54.37000 LogP 1.87 Vapour Pressure 0.0±1.0 mmHg at 25°C Index of Refraction 1.568 InChIKey YMBXTVYHTMGZDW-UHFFFAOYSA-N SMILES CC(C(=O)O)c1ccc(CC2CCCC2=O)cc1 |
| Use of | Loxoprofen is a non-steroidal anti-inflammatory drug.Target: COXLoxoprofen is a non-steroidal anti-inflammatory drug in the propionic acid derivatives group, which also includes ibuprofen and naproxen among others. Loxoprofen is a non-selective cyclooxygenase inhibitor, and works by reducing the synthesis of prostaglandins from arachidonic acid. Properties Articles33 Name loxoprofen Synonym More Synonyms Loxoprofen Biological Activity Description Loxoprofen is a non-steroidal anti-inflammatory drug.Target: COXLoxoprofen is a non-steroidal anti-inflammatory drug in the propionic acid derivatives group, which also includes ibuprofen and naproxen among others. Loxoprofen is a non-selective cyclooxygenase inhibitor, and works by reducing the synthesis of prostaglandins from arachidonic acid. Related Catalog Research Areas >> Inflammation/Immunology COX-1:6.5 μM (IC50, in human whole blood) COX-2:13.5 μM (IC50, in human whole blood) References [1]. Riendeau D, et al. Evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2. Bioorg Med Chem Lett. 2004 Mar 8;14(5):1201-3. Chemical & Physical Properties Molecular Formula C15H18O3 Exact Mass 246.125595 PSA 54.37000 Index of Refraction 1.568 InChIKey YMBXTVYHTMGZDW-UHFFFAOYSA-N |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 97.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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