CAS Number68291-98-5
Synonymssodium,1,2-benzoxazol-3-ylmethylsulfonylazanide; Sodium [(1,2-benzoxazol-3-ylmethyl)sulfonyl]azanide; 1,2-Benzisoxazole-3-methanesulfonamide, sodium salt (1:1); Zonisamide (sodium)
Molecular FormulaC8H7N2NaO3S
Molecular Weight234.21
Purity≥98 (HPLC)%
Boiling Point457.2ºC at 760 mmHg
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 68291-98-5 |
| Catalog No. | 2A-9046761 |
| Chinese Name | 唑尼沙胺钠 |
| Synonyms | sodium,1,2-benzoxazol-3-ylmethylsulfonylazanide; Sodium [(1,2-benzoxazol-3-ylmethyl)sulfonyl]azanide; 1,2-Benzisoxazole-3-methanesulfonamide, sodium salt (1:1); Zonisamide (sodium) |
| Molecular Formula | C8H7N2NaO3S |
| Molecular Weight | 234.21 |
| Purity | ≥98 (HPLC) |
| Boiling Point | 457.2ºC at 760 mmHg |
| Appearance | powder |
| Storage Condition | 2-8℃ |
| Application | Zonisamide sodium is a 1,2-benzenisoxazole derivative with anti-epileptic activity. |
| PubChem ID | 24278783 |
| MDL Number | MFCD01744844 |
| SMILES | [Na]NS(=O)(=O)Cc1noc2ccccc12 |
| InChI | 1S/C8H7N2O3S.Na/c9-14(11,12)5-7-6-3-1-2-4-8(6)13-10-7;/h1-4H,5H2,(H-,9,11,12);/q-1;+1 |
| InChI Key | ZVBIRPKGWOVBLG-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | transportation |
| MSDS | msds/46761_1_68291_98_5.pdf |
| Bioactivity | Zonisamide sodium is a 1,2 benzisoxazole derivative and the first agent of this chemical class to be developed as an antiepileptic drug.Target: Calcium channel inhibitor; Sodium channel inhibitorZonisamide sodium is a sulfonamide anticonvulsant approved for use as an adjunctive therapy in adults with partial-onset seizures for adults; infantile spasm, mixed seizure types of Lennox-Gastaut syndrome, myoclonic, and generalized tonic clonic seizure. Zonisamide sodium is a 1,2 benzisoxazole derivative and the first agent of this chemical class to be developed as an antiepileptic drug. It has shown activity in various animal models of epilepsy, and although a detailed mode of action awaits clarification it appears to block the propagation/spread of seizure discharges and to suppress the epileptogenic focus [1].Zonisamide sodium 500 mg/day was significantly superior to placebo in reducing the frequency of complex partial seizures (-51% versus -16%), all partial seizures and all seizures, with dose-dependent benefit provided over a 100-500 mg/day dose range. Supporting trials have confirmed significant increases in reduction in median seizure frequency (up to 41%) and responder rates (35-42%) compared with placebo following zonisamide sodium 400-600 mg/day, enabling 20-27% of patients to attain >or=75% reduction in seizure frequency [2].Clinical indications: Epilepsy; Lewy body dementia; Parkinsons diseaseToxicity: Anorexia; Somnolence; Dizziness; Irritability; Confusional state; Depression; Diplopia; Memory impairment Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease References [1]. Peters DH, et al. Zonisamide. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in epilepsy. Drugs. 1993 May;45(5):760-87. [2]. Brodie MJ, et al. Zonisamide as adjunctive therapy for refractory partial seizures. Epilepsy Res. 2006 Feb;68 Suppl 2:S11-6. Epub 2005 Nov 28. Chemical & Physical Properties Boiling Point 457.2ºC at 760 mmHg Molecular Formula C8H7N2NaO3S Molecular Weight 234.208 Exact Mass 234.007507 PSA 80.58000 LogP 2.18320 InChIKey ZVBIRPKGWOVBLG-UHFFFAOYSA-N SMILES [NH-]S(=O)(=O)Cc1noc2ccccc12.[Na+] Storage condition 2-8℃ |
| Use of | Properties Articles32 Name Zonisamide sodium salt Synonym More Synonyms Zonisamide sodium Biological Activity Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease References [1]. Peters DH, et al. Zonisamide. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in epilepsy. Drugs. 1993 May;45(5):760-87. [2]. Brodie MJ, et al. Zonisamide as adjunctive therapy for refractory partial seizures. Epilepsy Res. 2006 Feb;68 Suppl 2:S11-6. Epub 2005 Nov 28. Chemical & Physical Properties Molecular Formula C8H7N2NaO3S Exact Mass 234.007507 PSA 80.58000 LogP 2.18320 InChIKey ZVBIRPKGWOVBLG-UHFFFAOYSA-N Storage condition 2-8℃ |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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