CAS Number68181-17-9
SynonymsMFCD00009636; 1-{[3-(2-Pyridinyldisulfanyl)propanoyl]oxy}-2,5-pyrrolidinedione; EINECS 269-034-3; N-succinimidyl 3-(2-pyridyldithio)-propionate; (2,5-dioxopyrrolidin-1-yl) 3-(pyridin-2-yldisulfanyl)propanoate; 1-{[3-(Pyridin-2-yldisulfanyl)propanoyl]oxy}pyrrolidine-2,5-dione; 1-(1-Oxo-3-(2-pyridyldithio)propoxy)pyrrolidine-2,5-dione; SPDP
Molecular FormulaC12H12N2O4S2
Molecular Weight312.36
Purity≥95%
Density1.5±0.1 g/cm3
Boiling Point465.9±55.0 °C at 760 mmHg
Melting Point84-86 °C (lit.)
Appearancepowder
EINECS269-034-3
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 68181-17-9 |
| Catalog No. | 2A-9046729 |
| Chinese Name | 3-(2-吡啶二硫代)丙酸 N-琥珀酰亚胺酯 |
| Synonyms | MFCD00009636; 1-{[3-(2-Pyridinyldisulfanyl)propanoyl]oxy}-2,5-pyrrolidinedione; EINECS 269-034-3; N-succinimidyl 3-(2-pyridyldithio)-propionate; (2,5-dioxopyrrolidin-1-yl) 3-(pyridin-2-yldisulfanyl)propanoate; 1-{[3-(Pyridin-2-yldisulfanyl)propanoyl]oxy}pyrrolidine-2,5-dione; 1-(1-Oxo-3-(2-pyridyldithio)propoxy)pyrrolidine-2,5-dione; SPDP |
| Molecular Formula | C12H12N2O4S2 |
| Molecular Weight | 312.36 |
| Purity | ≥95 |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 465.9±55.0 °C at 760 mmHg |
| Melting Point | 84-86 °C (lit.) |
| Appearance | powder |
| Water Solubility | acetone: 50 mg/mL |
| Storage Condition | Store in an airtight container in a cool, dry plac |
| Application | SPDP is a short-chain cross-linking agent for hydrogen sulfide and can be activated by NHS lipids to form disulfide bonds. |
| EINECS | 269-034-3 |
| PubChem ID | 24898409 |
| MDL Number | MFCD00009636 |
| SMILES | O=C(CCSSC1=NC=CC=C1)ON2C(CCC2=O)=O |
| InChI | 1S/C12H12N2O4S2/c15-10-4-5-11(16)14(10)18-12(17)6-8-19-20-9-3-1-2-7-13-9/h1-3,7H,4-6,8H2 |
| InChI Key | JWDFQMWEFLOOED-UHFFFAOYSA-N |
| Beilstein/REAXYS | 1548137 |
| NACRES Code | NC.07 |
| UNSPSC | 12352106 |
| Bioactivity | SPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. equal amounts of anti-CD11c and anti-CTLA-4 Abs (in borate buffered saline; pH 8.5) were activated using SPDP . Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Others References [1]. Lobedanz S et al. A periplasmic coiled-coil interface underlying TolC recruitment and the assembly of bacterial drug effluxpumps. Proc Natl Acad Sci U S A, 2007 Mar 13, 104(11):4612-7. [2]. Karumuthil-Melethil S et al. Dendritic cell-directed CTLA-4 engagement during pancreatic beta cell antigen presentation delays type 1diabetes. J Immunol 2010 Jun 15, 184(12):6695-708. Chemical & Physical Properties Density 1.5±0.1 g/cm3 Boiling Point 465.9±55.0 °C at 760 mmHg Melting Point 84-86 °C(lit.) Molecular Formula C12H12N2O4S2 Molecular Weight 312.365 Flash Point 235.6±31.5 °C Exact Mass 312.023834 PSA 127.17000 LogP 0.99 Vapour Pressure 0.0±1.2 mmHg at 25°C Index of Refraction 1.650 InChIKey JWDFQMWEFLOOED-UHFFFAOYSA-N SMILES O=C(CCSSc1ccccn1)ON1C(=O)CCC1=O Storage condition −20°C Water Solubility acetone: 50 mg/mL |
| Use of | Properties Articles53 Name N-Succinimidyl 3-(2-Pyridyldithio)propionate Synonym More Synonyms SPDP Biological Activity Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Others References [1]. Lobedanz S et al. A periplasmic coiled-coil interface underlying TolC recruitment and the assembly of bacterial drug effluxpumps. Proc Natl Acad Sci U S A, 2007 Mar 13, 104(11):4612-7. [2]. Karumuthil-Melethil S et al. Dendritic cell-directed CTLA-4 engagement during pancreatic beta cell antigen presentation delays type 1diabetes. J Immunol 2010 Jun 15, 184(12):6695-708. Chemical & Physical Properties Molecular Formula C12H12N2O4S2 Exact Mass 312.023834 PSA 127.17000 Index of Refraction 1.650 InChIKey JWDFQMWEFLOOED-UHFFFAOYSA-N |
| Transport Info | Product name: Purity: 95.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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