CAS Number64461-82-1
Synonyms5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine,hydrochloride; MFCD00798231
Molecular FormulaC9H9Cl2N5S
Molecular Weight290.17
Purity98.00%
Boiling Point391.2ºC at 760 mmHg
Melting Point280 °C
Appearancewhite solid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 64461-82-1 |
| Catalog No. | 2A-9046098 |
| Chinese Name | 盐酸替扎尼定 |
| Synonyms | 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine,hydrochloride; MFCD00798231 |
| Molecular Formula | C9H9Cl2N5S |
| Molecular Weight | 290.17 |
| Purity | 98.00 |
| Boiling Point | 391.2ºC at 760 mmHg |
| Melting Point | 280 °C |
| Appearance | white solid |
| Water Solubility | H2O: ~29 mg/mL |
| Storage Condition | Store in an airtight container in a cool, dry plac |
| Application | Tizanidine hydrochloride is an α2-adrenergic receptor agonist that inhibits the release of neurotransmitters from CNS norepinephrine-activated neurons. |
| HTC | 2934300000 |
| PubChem ID | 329826628 |
| SMILES | Cl.Clc1ccc2nsnc2c1NC1=NCCN1 |
| InChI | InChI=1S/C9H8ClN5S.ClH/c10-5-1-2-6-8(15-16-14-6)7(5)13-9-11-3-4-12-9;/h1-2H,3-4H2,(H2,11,12,13);1H |
| InChI Key | ZWUKMNZJRDGCTQ-UHFFFAOYSA-N |
| Hazard Symbols | transportation |
| Bioactivity | Tizanidine hydrochloride is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons.Target: α2-adrenergic receptorTizanidine is a drug that is used as a muscle relaxant. It is a centrally acting α2 adrenergic agonist. It is used to treat the spasms, cramping, and tightness of muscles caused by medical problems such as multiple sclerosis, ALS, spastic diplegia, back pain, or certain other injuries to the spine or central nervous system. It is also prescribed off-label for migraine headaches, as a sleep aid, and as an anticonvulsant. It is also prescribed for some symptoms of fibromyalgia.Tizanidine has been found to be as effective as other antispasmodic drugs and has superior tolerability to that of baclofen and diazepam. Tizanidine can be very strong even at the 2 mg dose and may cause hypotension, so caution is advised when it is used in patients who have a history of orthostatic hypotension, or when switching from gel cap to tablet form and vice versa. Tizanidine can occasionally cause liver damage, generally the hepatocellular type. Clinical trials show that up to 5% of patients treated with tizanidine had elevated liver function test values, though symptoms disappeared upon withdrawal of the drug. Care should be used when first beginning treatment with tizanidine with regular liver tests for the first 6 months of treatment. Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease References [1]. Kamen L, et al. A practical overview of tizanidine use for spasticity secondary to multiple sclerosis, stroke, and spinal cord injury. Curr Med Res Opin. 2008 Feb;24(2):425-39. Chemical & Physical Properties Boiling Point 391.2ºC at 760 mmHg Melting Point 280 °C Molecular Formula C9H9Cl2N5S Molecular Weight 290.17200 Flash Point 190.4ºC Exact Mass 288.99600 PSA 90.44000 LogP 2.35520 InChIKey ZWUKMNZJRDGCTQ-UHFFFAOYSA-N SMILES Cl.Clc1ccc2nsnc2c1NC1=NCCN1 Storage condition Desiccate at RT Water Solubility H2O: ~29 mg/mL |
| Use of | Properties Name Tizanidine hydrochloride Synonym More Synonyms Tizanidine hydrochloride Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease References [1]. Kamen L, et al. A practical overview of tizanidine use for spasticity secondary to multiple sclerosis, stroke, and spinal cord injury. Curr Med Res Opin. 2008 Feb;24(2):425-39. Chemical & Physical Properties Exact Mass 288.99600 PSA 90.44000 LogP 2.35520 InChIKey ZWUKMNZJRDGCTQ-UHFFFAOYSA-N Storage condition Desiccate at RT |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available The above information is believed to be correct, but is not all-inclusive and should be used as a guide only. The information in this document is based on our current knowledge and is Correct safety instructions apply to this product. This information does not represent a warranty as to the properties of this product. See reverse side of invoice or packing slip. |
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