| Chemical & Physical Properties | |
|---|---|
| CAS Number | 64183-27-3 |
| Catalog No. | 2A-9046037 |
| Chinese Name | 2'-氟-2'-脱氧腺苷 |
| Synonyms | 2'F-dA; 2'-Deoxy-2'-fluoroadenosine; 2'-fluoro-2'-deoxy-adenosine; Adenosine,2'-deoxy-2'-fluoro |
| Molecular Formula | C10H12O3N5F1 |
| Molecular Weight | 269.24 |
| Purity | 98.00 |
| Density | 2.0±0.1 g/cm3 |
| Boiling Point | 628.6±65.0 °C at 760 mmHg |
| Storage Condition | 2-8°C, protected from light, dry and sealed |
| Application | 2′-Deoxy-2′-fluoroadenosine can be used to synthesize 2′-deoxy-2′-fluoro modified oligonucleotides that hybridize to RNA. 2′-Deoxy-2′-fluoroadenosine can be efficiently cleaved into the toxic substanc |
| HTC | 2934999090 |
| PubChem ID | 601573 |
| MDL Number | MFCD09750859 |
| SMILES | Nc1ncnc2c1ncn2C1OC(CO)C(O)C1F |
| InChI | InChI=1S/C10H12FN5O3/c11-5-7(18)4(1-17)19-10(5)16-3-15-6-8(12)13-2-14-9(6)16/h2-5,7,10,17-18H,1H2,(H2,12,13,14) |
| InChI Key | ZGYYPTJWJBEXBC-QYYRPYCUSA-N |
| MSDS | msds/46037_1_64183_27_3.pdf |
| Use of | 2′-Deoxy-2′-fluoroadenosine can be used for the synthesis of 2′-Deoxy-2′-fluoro-modified oligonucleotides hybridized with RNA. 2′-Deoxy-2′-fluoroadenosine can be cleaved efficiently by E. coli purine nucleoside phosphorylase (PNP) to the toxic agent 2-fluoroadenine (FAde) and shows excellent in vivo activity against tumors expressing E. coli PNP[1]. Properties Name (2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol Synonym More Synonyms 2′-Deoxy-2′-fluoroadenosine Biological Activity Description 2′-Deoxy-2′-fluoroadenosine can be used for the synthesis of 2′-Deoxy-2′-fluoro-modified oligonucleotides hybridized with RNA. 2′-Deoxy-2′-fluoroadenosine can be cleaved efficiently by E. coli purine nucleoside phosphorylase (PNP) to the toxic agent 2-fluoroadenine (FAde) and shows excellent in vivo activity against tumors expressing E. coli PNP[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog References [1]. A E Hassan, et al. A convenient synthesis of 2'-deoxy-2-fluoroadenosine; a potential prodrug for suicide gene therapy. Nucleosides Nucleotides Nucleic Acids. 2000 Mar;19(3):559-65. Chemical & Physical Properties Molecular Formula C10H12FN5O3 Exact Mass 269.092407 PSA 119.31000 LogP -0.32 Index of Refraction 1.834 InChIKey ZGYYPTJWJBEXBC-QYYRPYCUSA-N Safety Information HS Code 2934999090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| Related Products in Biotechnology & Diagnostics | ||
|---|---|---|
| N-Cbz-N'-Boc-D-2,3-diaminopropionic acid | 62234-36-0 | 2A-9045676 |
| N-alpha-Cbz-L-2,4-diamiobutyric acid | 62234-40-6 | 2A-9045678 |
| Boc-D-Aspartic acid | 62396-48-9 | 2A-9045702 |
| Cbz-L-tert-Leucine | 62965-10-0 | 2A-9045804 |
| Boc-O-benzyl-D-tyrosine | 63769-58-4 | 2A-9045964 |
| Boc-ONb | 64205-15-8 | 2A-9046041 |
| N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine | 64325-78-6 | 2A-9046078 |
| 3'-Azido-2',3'-dideoxyadenosine | 66323-44-2 | 2A-9046409 |
| 3'-Amino-2',3'-dideoxyguanosine | 66323-49-7 | 2A-9046410 |
| 5'-Deoxy-5-fluoro-2',3'-O-isopropylidene-D-cytidine | 66335-37-3 | 2A-9046411 |
| Browse all Biotechnology & Diagnostics products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS