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3-Hydroxyazetidine hydrochloride structure, CAS 18621-18-6

3-Hydroxyazetidine hydrochloride

CAS Number18621-18-6

Synonyms3-Azetidinol Hydrochloride; azetidin-3-ol monohydrochloride; MFCD02683887; Azetidin-3-ol hydrochloride; 3-hydroxyazetidine monohydrochloride; 3-Hydroxyazetidine-HCl; azetidin-3-ol-hydrochloride; 3-Azetidinol hydrochloride (1:1); 3-Azetidinol, hydrochloride (1:1); 3-hydroxy-1-azetidine hydrochloride; azetidin-3-ol hcl; 3-Hydroxyazetidine Hydrochloride; 3-hydroxyazetidinium chloride; 3 HYDROXY AZETIDINE HYDROCHLORIDE

Molecular FormulaC3H8ClNO

Molecular Weight109.55

Purity97%

Density

Boiling Point170.7ºC at 760 mmHg

Melting Point85-90 °C

Flash Point

Appearancesolid

EINECS

MSDSChineseEnglish

SymbolTransport

Signal WordWarning

Cat. No.: 2A-9004552 Purity: 97%
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Quality Control of [ 18621-18-6 ] Purity: 97% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number18621-18-6
Catalog No.2A-9004552
Chinese Name3-羟基氮杂环丁烷盐酸盐
Synonyms3-Azetidinol Hydrochloride; azetidin-3-ol monohydrochloride; MFCD02683887; Azetidin-3-ol hydrochloride; 3-hydroxyazetidine monohydrochloride; 3-Hydroxyazetidine-HCl; azetidin-3-ol-hydrochloride; 3-Azetidinol hydrochloride (1:1); 3-Azetidinol, hydrochloride (1:1); 3-hydroxy-1-azetidine hydrochloride; azetidin-3-ol hcl; 3-Hydroxyazetidine Hydrochloride; 3-hydroxyazetidinium chloride; 3 HYDROXY AZETIDINE HYDROCHLORIDE
Molecular FormulaC3H8ClNO
Molecular Weight109.55
Purity97
Boiling Point170.7ºC at 760 mmHg
Melting Point85-90 °C
Appearancesolid
Storage ConditionClosed at room temperature, protected from light,
ApplicationAzetidine-3-ol hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody drug conjugates (ADC). Azitidine-3-ol hydrochloride is also an alkyl chain-based PROTAC linker and can be u
HTC2933990090
PubChem ID24885534
MDL NumberMFCD02683887
SMILESCl[H].OC1CNC1
InChI1S/C3H7NO.ClH/c5-3-1-4-2-3;/h3-5H,1-2H2;1H
InChI KeyUQUPQEUNHVVNKW-UHFFFAOYSA-N
NACRES CodeNA.22
UNSPSC12352100
Hazard SymbolsTransport
MSDSmsds/4552_1_18621_18_6.pdf
BioactivityAzetidin-3-ol hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azetidin-3-ol hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthes PROTAC. Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker Target Non-cleavable In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. References [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. Chemical & Physical Properties Boiling Point 170.7ºC at 760 mmHg Melting Point 90-92°C Molecular Formula C3H8ClNO Molecular Weight 109.555 Flash Point 120.4ºC Exact Mass 109.029442 PSA 32.26000 LogP 0.08130 Vapour Pressure 0.464mmHg at 25°C InChIKey UQUPQEUNHVVNKW-UHFFFAOYSA-N SMILES Cl.OC1CNC1 Storage condition Room temperature.
Use ofAzetidin-3-ol hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azetidin-3-ol hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthes PROTAC. Properties Name azetidin-3-ol,hydrochloride Synonym More Synonyms Azetidin-3-ol hydrochloride Biological Activity Description Azetidin-3-ol hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azetidin-3-ol hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthes PROTAC. Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker Non-cleavable In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. References [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. Chemical & Physical Properties Exact Mass 109.029442 PSA 32.26000 LogP 0.08130 InChIKey UQUPQEUNHVVNKW-UHFFFAOYSA-N Storage condition Room temperature.
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available
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