CAS Number61278-30-6
SynonymsD-Saccharolactone; D-Saccharic acid 1,4-lactone monohydrate; D-Glucaro-1,4-lactone Monohydrate; 1,4-Lactone-D-glucaric Acid Monohydrate; D-Glucaro-1,4-lacton; D-Glucaric acid-1,4-lactone; MFCD00149334
Molecular FormulaC6H10O8
Molecular Weight210.14
Purity≥98.0 (HPLC)%
Melting Point91 - 93 °C ((196 - 199 °F ))
Appearancepowder
Symbol
Signal WordWarning
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| Chemical & Physical Properties | |
|---|---|
| CAS Number | 61278-30-6 |
| Catalog No. | 2A-9045459 |
| Chinese Name | D-葡糖二酸-1,4-内酯 |
| Synonyms | D-Saccharolactone; D-Saccharic acid 1,4-lactone monohydrate; D-Glucaro-1,4-lactone Monohydrate; 1,4-Lactone-D-glucaric Acid Monohydrate; D-Glucaro-1,4-lacton; D-Glucaric acid-1,4-lactone; MFCD00149334 |
| Molecular Formula | C6H10O8 |
| Molecular Weight | 210.14 |
| Purity | ≥98.0 (HPLC) |
| Melting Point | 91 - 93 °C ((196 - 199 °F )) |
| Appearance | powder |
| Storage Condition | Sealed in a cool, dry environment at 2-8 ºC |
| Application | β-glucuronidase inhibitor (β-IC4.50-potent). Compared with the new β-glucuronidase inhibitors, D-glycolic acid 1,4-lactone hydrate can be used as a standard drug. D-glycolic acid 1,4-lactone hydrate h |
| HTC | 2932190090 |
| PubChem ID | 24899420 |
| MDL Number | MFCD00149334 |
| SMILES | O.O[C@@H]1[C@@H](O)C(=O)O[C@@H]1[C@H](O)C(O)=O |
| InChI | 1S/C6H8O7.H2O/c7-1-2(8)6(12)13-4(1)3(9)5(10)11;/h1-4,7-9H,(H,10,11);1H2/t1-,2-,3+,4+;/m1./s1 |
| InChI Key | NPFKVZHSFSFLPU-QGBSHYGGSA-N |
| Beilstein/REAXYS | 85594 |
| NACRES Code | NA.25 |
| UNSPSC | 12352201 |
| Hazard Symbols | transportation |
| Bioactivity | D-Saccharic acid 1,4-lactone hydrate is a potent β-glucuronidase inhibitor (IC50=48.4 μM). D-Saccharic acid 1,4-lactone hydrate can be used as a standard drug compared with novel β-glucuronidase inhibitors. D-Saccharic acid 1,4-lactone hydrate possesses anticarcinogenic, detoxifying, and antioxidant properties[1][2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Others >> Others References [1]. Taha M, et al. Synthesis, β-glucuronidase inhibition and molecular docking studies of hybrid bisindole-thiosemicarbazides analogs. Bioorg Chem. 2016;68:56-63. [2]. Bhattacharya S, et al. Prophylactic role of D-Saccharic acid-1,4-lactone in tertiary butyl hydroperoxide induced cytotoxicity and cell death of murine hepatocytes via mitochondria-dependent pathways. J Biochem Mol Toxicol. 2011;25(6):341-354. Chemical & Physical Properties Melting Point 80-82ºC Molecular Formula C6H10O8 Molecular Weight 192.12400 Exact Mass 192.02700 PSA 124.29000 Storage condition 2-8°C |
| Use of | D-Saccharic acid 1,4-lactone hydrate is a potent β-glucuronidase inhibitor (IC50=48.4 μM). D-Saccharic acid 1,4-lactone hydrate can be used as a standard drug compared with novel β-glucuronidase inhibitors. D-Saccharic acid 1,4-lactone hydrate possesses anticarcinogenic, detoxifying, and antioxidant properties[1][2]. Properties Name (2S)-2-[(3R,4R)-3,4-dihydroxy-5-oxooxolan-2-yl]-2-hydroxyacetic acid,hydrate Synonym More Synonyms D-Saccharic acid 1,4-lactone hydrate Biological Activity Description D-Saccharic acid 1,4-lactone hydrate is a potent β-glucuronidase inhibitor (IC50=48.4 μM). D-Saccharic acid 1,4-lactone hydrate can be used as a standard drug compared with novel β-glucuronidase inhibitors. D-Saccharic acid 1,4-lactone hydrate possesses anticarcinogenic, detoxifying, and antioxidant properties[1][2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Others >> Others References [1]. Taha M, et al. Synthesis, β-glucuronidase inhibition and molecular docking studies of hybrid bisindole-thiosemicarbazides analogs. Bioorg Chem. 2016;68:56-63. [2]. Bhattacharya S, et al. Prophylactic role of D-Saccharic acid-1,4-lactone in tertiary butyl hydroperoxide induced cytotoxicity and cell death of murine hepatocytes via mitochondria-dependent pathways. J Biochem Mol Toxicol. 2011;25(6):341-354. Chemical & Physical Properties Molecular Formula C6H10O8 Exact Mass 192.02700 PSA 124.29000 |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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