CAS Number60940-34-3
Synonyms2-Phenyl-1,2-benzoselenazol-3(2H)-one; Ebselenum; 2-phenyl-1,2-benzoselenazol-3-one; Harmokisane; Ebselen; MFCD00210937; Ebseleno; Ebselene
Molecular FormulaC13H9NOSe
Molecular Weight274.18
Purity97.00%
Boiling Point402.8±28.0 °C at 760 mmHg
Melting Point178-181 °C
Appearancewhite solid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 60940-34-3 |
| Catalog No. | 2A-9045410 |
| Chinese Name | 依布硒 |
| Synonyms | 2-Phenyl-1,2-benzoselenazol-3(2H)-one; Ebselenum; 2-phenyl-1,2-benzoselenazol-3-one; Harmokisane; Ebselen; MFCD00210937; Ebseleno; Ebselene |
| Molecular Formula | C13H9NOSe |
| Molecular Weight | 274.18 |
| Purity | 97.00 |
| Boiling Point | 402.8±28.0 °C at 760 mmHg |
| Melting Point | 178-181 °C |
| Appearance | white solid |
| Storage Condition | 2-8℃ |
| Application | Ebselen is a small molecule inhibitor of HIV-1 replication and an antioxidant drug. |
| HTC | 2927000090 |
| PubChem ID | 499808 |
| SMILES | O=c1c2ccccc2[se]n1-c1ccccc1 |
| InChI | InChI=1S/C13H9NOSe/c15-13-11-8-4-5-9-12(11)16-14(13)10-6-2-1-3-7-10/h1-9H |
| InChI Key | DYEFUKCXAQOFHX-UHFFFAOYSA-N |
| Hazard Symbols | transportation |
| Bioactivity | Ebselen is a small-molecule capsid Inhibitor of HIV-1 replication.Target:Ebselen is an organoselenium compound, as an inhibitor of HIV-1 capsid CTD dimerization. Ebselen inhibits early viral postentry events of the HIV-1 life cycle by impairing the incoming capsid uncoating process. [1] Ebselen is a non-toxic seleno-organic drug with anti-inflammatory and antioxidant properties. Ebselen is an inhibitor of inositol monophosphatase (IMPase). Ebselen permeates the blood-brain barrier and inhibits endogenous inositol monophosphatase in mouse brain. [2] Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Anti-infection >> HIV Research Areas >> Inflammation/Immunology References [1]. Thenin-Houssier S, et al. Ebselen, a Small-Molecule Capsid Inhibitor of HIV-1 Replication. Antimicrob Agents Chemother. 2016 Mar 25;60(4):2195-208. [2]. Singh N, et al. A safe lithium mimetic for bipolar disorder. Nat Commun. 2013;4:1332. doi: 10.1038/ncomms2320. Chemical & Physical Properties Boiling Point 402.8±28.0 °C at 760 mmHg Melting Point 178-181 °C Molecular Formula C13H9NOSe Molecular Weight 274.177 Flash Point 197.4±24.0 °C Exact Mass 274.984924 PSA 22.00000 LogP 2.04770 Vapour Pressure 0.0±0.9 mmHg at 25°C InChIKey DYEFUKCXAQOFHX-UHFFFAOYSA-N SMILES O=c1c2ccccc2[se]n1-c1ccccc1 Storage condition 2-8°C |
| Use of | Properties Articles54 Name ebselen Synonym More Synonyms Ebselen Biological Activity Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Anti-infection >> HIV Research Areas >> Inflammation/Immunology References [1]. Thenin-Houssier S, et al. Ebselen, a Small-Molecule Capsid Inhibitor of HIV-1 Replication. Antimicrob Agents Chemother. 2016 Mar 25;60(4):2195-208. Chemical & Physical Properties Molecular Formula C13H9NOSe Exact Mass 274.984924 PSA 22.00000 LogP 2.04770 InChIKey DYEFUKCXAQOFHX-UHFFFAOYSA-N |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 30.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Danger Regulations: 3283 International Maritime Danger Regulations: 3283 International Air Transport Danger Regulations: 3283 14.2 United Nations shipping name European Land Transport Dangerous Regulations: SELENIUM COMPOUND, SOLID, N.O.S. (2-Phenyl-1,2-benzisoselenazol-3(2H)-one) IMDG: SELENIUM COMPOUND, SOLID, N.O.S. (2-Phenyl-1,2-benzisoselenazol-3(2H)-one) International air transport hazard regulations: Selenium compound, solid, n.o.s. (2-Phenyl-1,2-benzisoselenazol-3(2H)-one) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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