| Chemical & Physical Properties | |
|---|---|
| CAS Number | 59917-39-4 |
| Catalog No. | 2A-9045272 |
| Chinese Name | 硫酸长春地辛 |
| Synonyms | Vindesine Sulfate Salt; Vindesine sulphate |
| Molecular Formula | C43H57N5O11S |
| Molecular Weight | 852.02 |
| Purity | 98.00 |
| Density | 1.41 g/cm3 |
| Melting Point | >250ºC |
| Appearance | amorphous solid |
| Water Solubility | deionized water: ≥50mg/mL |
| Storage Condition | 2-8°C |
| Packaging | II |
| Application | Vindesine sulfate is a potent tubulin inhibitor with a Ki of 0.110µM. Vindesine sulfate has antiproliferative effects in vitro. Vindesine sulfate has anti-tumor effects in the body [1]. |
| HTC | 2942000000 |
| PubChem ID | 7848832 |
| MDL Number | C43H57N5O11S |
| SMILES | CCC1(O)CC2CN(CCc3c([nH]c4ccccc34)C(C(=O)OC)(c3cc4c(cc3OC)N(C)C3C(O)(C(N)=O)C(O)C5(CC)C=CCN6CCC43C65)C2)C1.O=S(=O)(O)O |
| InChI | InChI=1S/C43H55N5O7.H2O4S/c1-6-39(52)21-25-22-42(38(51)55-5,33-27(13-17-47(23-25)24-39)26-11-8-9-12-30(26)45-33)29-19-28-31(20-32(29)54-4)46(3)35-41(28)15-18-48-16-10-14-40(7-2,34(41)48)36(49)43(35,53)37(44)50;1-5(2,3)4/h8-12,14,19-20,25,34-36,45,49,52-53H,6-7,13,15-18,21-24H2,1-5H3,(H2,44,50);(H2,1,2,3,4)/t25-,34+,35-,36-,39+,40-,41-,42+,43+;/m1./s1 |
| InChI Key | COFJBSXICYYSKG-UNNXMZBYSA-N |
| Hazard Symbols | 6.1(a) |
| MSDS | msds/45272_1_59917_39_4.pdf |
| Use of | Vindesine sulfate is a potent tubulin inhibitor with an Ki of 0.110 µM. Vindesine sulfate shows anti-proliferation effect in vitro. Vindesine sulfate shows antitumor effect in vivo[1]. Properties Name vindesine sulfate Synonym More Synonyms Vindesine sulfate Biological Activity Description Vindesine sulfate is a potent tubulin inhibitor with an Ki of 0.110 µM. Vindesine sulfate shows anti-proliferation effect in vitro. Vindesine sulfate shows antitumor effect in vivo[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin In Vitro Vindesine sulfate inhibits L-cells growth and shows about 25% inhibition at 40 nM[1]. References [1]. Jordan MA, et al. Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitro. Cancer Res. 1985 Jun;45(6):2741-7. Chemical & Physical Properties Molecular Formula C43H57N5O11S Exact Mass 851.377502 PSA 247.80000 LogP 3.80150 InChIKey COFJBSXICYYSKG-UNNXMZBYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CAS REGISTRY NUMBER : 59917-39-4 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C43-H55-N5-O7.H2-O4-S MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1050 ug/kg TOXIC EFFECTS : Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea Kidney, Ureter, Bladder - urine volume increased TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1790 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1920 ug/kg TOXIC EFFECTS : Gastrointestinal - hypermotility, diarrhea Kidney, Ureter, Bladder - urine volume increased Blood - normocytic anemia TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3500 ug/kg TOXIC EFFECTS : Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea Kidney, Ureter, Bladder - urine volume increased TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 6800 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 6300 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1250 ug/kg/33D-I TOXIC EFFECTS : Endocrine - other changes Blood - changes in bone marrow (not otherwise specified) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous 1250 ug/kg SEX/DURATION : male 10 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands TYPE OF TEST : Micronucleus test MUTATION DATA TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Rodent - hamster Ovary DOSE/DURATION : REFERENCE : Safety Information Hazard Codes Xn: Harmful; Risk Phrases R40 Safety Phrases 26-36 RIDADR UN 1544 RTECS YY8090000 Packaging Group II Hazard Class 6.1(a) HS Code 2942000000 |
| Transport Info | Product name: Vindesine sulfate |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| [1,3-Bis(diphenylphosphino)propane]palladium(II) dichloride | 59831-02-6 | 2A-9045256 |
| Isopropyl ferulate | 59831-94-6 | 2A-9045257 |
| Ammonium dodecanedioate | 59864-79-8 | 2A-9045263 |
| 4-Phenoxy-2',2'-dichloroacetophenone | 59867-68-4 | 2A-9045265 |
| 2-(3-Phenoxyphenyl)propanal | 59908-87-1 | 2A-9045271 |
| Piperazin-1-yl-thiophen-3-yl-methanone | 59939-74-1 | 2A-9045275 |
| Pyrazolo[1,5-a]pyridin-2(1H)-one | 59942-87-9 | 2A-9045276 |
| Amino(pyridin-3-yl)acetic acid | 59966-29-9 | 2A-9045280 |
| Pivaloylacetonitrile | 59997-51-2 | 2A-9045282 |
| 2-(2-Chloroethyl)piperidinium chloride | 60012-49-9 | 2A-9045285 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS