CAS Number58543-16-1
SynonymsTruvia; Stevioside A3; Rebaudioside A; rebiana
Molecular FormulaC44H70O23
Molecular Weight967.01
Purity98.00%
Density1.6±0.1 g/cm3
Boiling Point1102.8±65.0 °C at 760 mmHg
Melting Point242-244ºC
AppearanceSolid;White to Almost white powder to crystal
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 58543-16-1 |
| Catalog No. | 2A-9045016 |
| Chinese Name | 甜菊双糖苷A |
| Synonyms | Truvia; Stevioside A3; Rebaudioside A; rebiana |
| Molecular Formula | C44H70O23 |
| Molecular Weight | 967.01 |
| Purity | 98.00 |
| Density | 1.6±0.1 g/cm3 |
| Boiling Point | 1102.8±65.0 °C at 760 mmHg |
| Melting Point | 242-244ºC |
| Appearance | Solid;White to Almost white powder to crystal |
| Water Solubility | Water solubility: soluble |
| Storage Condition | Store in an airtight container in a dry, cool plac |
| Application | Rebaudioside A is a steviol glycoside, α-glucosidase inhibitor, IC50 is 35.01 ug/mL |
| HTC | 29389090 |
| PubChem ID | 12015932 |
| SMILES | C=C1CC23CCC4C(C)(C(=O)OC5OC(CO)C(O)C(O)C5O)CCCC4(C)C2CCC1(OC1OC(CO)C(O)C(OC2OC(CO)C(O)C(O)C2O)C1OC1OC(CO)C(O)C(O)C1O)C3 |
| InChI | InChI=1S/C44H70O23/c1-17-11-43-9-5-22-41(2,7-4-8-42(22,3)40(59)66-38-33(58)30(55)26(51)20(14-47)62-38)23(43)6-10-44(17,16-43)67-39-35(65-37-32(57)29(54)25(50)19(13-46)61-37)34(27(52)21(15-48)63-39)64-36-31(56)28(53)24(49)18(12-45)60-36/h18-39,45-58H,1,4-16H2,2-3H3/t18-,19-,20-,21-,22+,23+,24-,25-,26-,27-,28+,29+,30+,31-,32-,33-,34+,35-,36+,37+,38+,39+,41-,42-,43-,44+/m1/s1 |
| InChI Key | HELXLJCILKEWJH-NCGAPWICSA-N |
| Hazard Symbols | transportation |
| Bioactivity | Rebaudioside A is a steviol glycoside, α-glucosidase inhibitor with IC50 of 35.01 μg/ml.can inhibit ATP-sensitive K+-channels.Target: α-glucosidase [1]IC 50: 35.01 ug/mLIn vitro: rebaudioside A stimulat the insulin secretion from MIN6 cells in a dose- and glucose-dependent manner. In conclusion, the insulinotropic effect of rebaudioside A is mediated via inhibition of ATP-sensitive K+-channels and requires the presence of high glucose. [2]In vivo: in vivo mouse micronucleus test at doses up to 750 mg/kg bw and an unscheduled DNA synthesis test in rats at doses up to 2000 mg/kg bw, rebaudioside A do not cause any genotoxic effects at any of the doses tested.[3] Related Catalog Signaling Pathways >> Others >> Others Natural Products >> Terpenoids and Glycosides Research Areas >> Others References [1]. Adari BR et al. Synthesis of rebaudioside-A by enzymatic transglycosylation of stevioside present in the leaves of Stevia rebaudiana Bertoni. Food Chem. 2016 Jun 1;200:154-8. [2]. Abudula R et al. Rebaudioside A directly stimulates insulin secretion from pancreatic beta cells: a glucose-dependent action via inhibition of ATP-sensitive K-channels. Diabetes Obes Metab. 2008 Nov;10(11):1074-85. [3]. Williams LD et al. Genotoxicity studies on a high-purity rebaudioside A preparation. Food Chem Toxicol. 2009 Aug;47(8):1831-6. Chemical & Physical Properties Density 1.6±0.1 g/cm3 Boiling Point 1102.8±65.0 °C at 760 mmHg Melting Point 242-244ºC Molecular Formula C44H70O23 Molecular Weight 967.013 Flash Point 319.9±27.8 °C Exact Mass 966.430786 PSA 374.13000 LogP -1.13 Vapour Pressure 0.0±0.6 mmHg at 25°C Index of Refraction 1.659 InChIKey HELXLJCILKEWJH-NCGAPWICSA-N SMILES C=C1CC23CCC4C(C)(C(=O)OC5OC(CO)C(O)C(O)C5O)CCCC4(C)C2CCC1(OC1OC(CO)C(O)C(OC2OC(CO)C(O)C(O)C2O)C1OC1OC(CO)C(O)C(O)C1O)C3 Storage condition room temp |
| Use of | Properties Articles26 Name Rebaudioside A Synonym More Synonyms Rebaudioside A Biological Activity Related Catalog Signaling Pathways >> Others >> Others Natural Products >> Terpenoids and Glycosides Research Areas >> Others References [1]. Adari BR et al. Synthesis of rebaudioside-A by enzymatic transglycosylation of stevioside present in the leaves of Stevia rebaudiana Bertoni. Food Chem. 2016 Jun 1;200:154-8. [2]. Abudula R et al. Rebaudioside A directly stimulates insulin secretion from pancreatic beta cells: a glucose-dependent action via inhibition of ATP-sensitive K-channels. Diabetes Obes Metab. 2008 Nov;10(11):1074-85. [3]. Williams LD et al. Genotoxicity studies on a high-purity rebaudioside A preparation. Food Chem Toxicol. 2009 Aug;47(8):1831-6. Chemical & Physical Properties Molecular Formula C44H70O23 Exact Mass 966.430786 PSA 374.13000 LogP -1.13 Index of Refraction 1.659 InChIKey HELXLJCILKEWJH-NCGAPWICSA-N Storage condition room temp |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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