CAS Number57079-01-3
Synonyms11-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)undecanoic acid; 11-maleimido-undecanoic acid; UNII-LG78EY7HVB; maleimidoundecanoic acid
Molecular FormulaC15H23NO4
Molecular Weight281.35
Purity95 (GC)%
Density1.1±0.1 g/cm3
Boiling Point452.8±18.0 °C at 760 mmHg
Melting Point94-98 °C
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 57079-01-3 |
| Catalog No. | 2A-9044756 |
| Chinese Name | 11-马来酰胺基十一烷酸 |
| Synonyms | 11-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)undecanoic acid; 11-maleimido-undecanoic acid; UNII-LG78EY7HVB; maleimidoundecanoic acid |
| Molecular Formula | C15H23NO4 |
| Molecular Weight | 281.35 |
| Purity | 95 (GC) |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 452.8±18.0 °C at 760 mmHg |
| Melting Point | 94-98 °C |
| Appearance | powder |
| Storage Condition | -20°C |
| Application | 11-Maleimidoundecanoic acid is a PROTAC linker, belonging to the alkyl chain class. Can be used to synthesize PROTAC molecules. |
| HTC | 2925190090 |
| PubChem ID | 329766146 |
| MDL Number | MFCD00941279 |
| SMILES | OC(=O)CCCCCCCCCCN1C(=O)C=CC1=O |
| InChI | 1S/C15H23NO4/c17-13-10-11-14(18)16(13)12-8-6-4-2-1-3-5-7-9-15(19)20/h10-11H,1-9,12H2,(H,19,20) |
| InChI Key | UVZTZBRGZXIBLZ-UHFFFAOYSA-N |
| NACRES Code | NA.23 |
| UNSPSC | 12162002 |
| Hazard Symbols | transportation |
| MSDS | msds/44756_1_57079_01_3.pdf |
| Bioactivity | 11-Maleimidoundecanoic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker Target Alkyl-Chain In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. References [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 452.8±18.0 °C at 760 mmHg Melting Point 89-90ºC Molecular Formula C15H23NO4 Molecular Weight 281.347 Flash Point 227.6±21.2 °C Exact Mass 281.162720 PSA 74.68000 LogP 3.36 Vapour Pressure 0.0±2.4 mmHg at 25°C Index of Refraction 1.515 InChIKey UVZTZBRGZXIBLZ-UHFFFAOYSA-N SMILES O=C(O)CCCCCCCCCCN1C(=O)C=CC1=O Storage condition -20°C |
| Use of | 11-Maleimidoundecanoic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Properties Name 11-(2,5-dioxopyrrol-1-yl)undecanoic acid Synonym More Synonyms 11-Maleimidoundecanoic acid Biological Activity Description 11-Maleimidoundecanoic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker Alkyl-Chain In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. References [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 Chemical & Physical Properties Molecular Formula C15H23NO4 Exact Mass 281.162720 PSA 74.68000 Index of Refraction 1.515 InChIKey UVZTZBRGZXIBLZ-UHFFFAOYSA-N |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 95.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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