CAS Number101-26-8
Synonyms3-(Dimethylcarbamoyloxy)-1-methylpyridinium Bromide; Pyridostigminbromid; mestinonbromide; EINECS 202-929-9; ro1-5130; 3-Dimethylcarbamoyloxy-1-methyl-pyridinium,Bromid; pyridostigmine; 3-dimethylcarbamoyloxy-1-methyl-pyridinium,bromide; MFCD00079283; pyridostigmine bromide; Pyridinium, 3-(((dimethylamino)carbonyl)oxy)-1-methyl-, bromide; regonal; kalymin; Pyridinium, 3-[[(dimethylamino)carbonyl]oxy]-1-methyl-, bromide (1:1); 3-Hydroxy-1; 3-((Dimethylcarbamoyl)oxy)-1-methylpyridin-1-ium bromide; mestinonebromide; pyridostygmine bromide; 3-[(Dimethylcarbamoyl)oxy]-1-methylpyridinium bromide; 3-[[(Dimethylamino)carbonyl]oxy]-1-methylpyridinium Bromide; Pyridostigmine (bromide); 3-{[(dimethylamino)carbonyl]oxy}-1-methylpyridinium bromide; pyridinium, 3-[[(dimethylamino)carbonyl]oxy]-1-methyl-
Molecular FormulaC9H13BrN2O2
Molecular Weight261.12
Purity98%
Density0.9613 g/cm3 (20ºC)
Boiling Point88 (25 torr)
Melting Point154 °C
AppearanceLight yellow to colorless liquid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 101-26-8 |
| Catalog No. | 2A-9004434 |
| Chinese Name | 溴吡斯的明 |
| Synonyms | 3-(Dimethylcarbamoyloxy)-1-methylpyridinium Bromide; Pyridostigminbromid; mestinonbromide; EINECS 202-929-9; ro1-5130; 3-Dimethylcarbamoyloxy-1-methyl-pyridinium,Bromid; pyridostigmine; 3-dimethylcarbamoyloxy-1-methyl-pyridinium,bromide; MFCD00079283; pyridostigmine bromide; Pyridinium, 3-(((dimethylamino)carbonyl)oxy)-1-methyl-, bromide; regonal; kalymin; Pyridinium, 3-[[(dimethylamino)carbonyl]oxy]-1-methyl-, bromide (1:1); 3-Hydroxy-1; 3-((Dimethylcarbamoyl)oxy)-1-methylpyridin-1-ium bromide; mestinonebromide; pyridostygmine bromide; 3-[(Dimethylcarbamoyl)oxy]-1-methylpyridinium bromide; 3-[[(Dimethylamino)carbonyl]oxy]-1-methylpyridinium Bromide; Pyridostigmine (bromide); 3-{[(dimethylamino)carbonyl]oxy}-1-methylpyridinium bromide; pyridinium, 3-[[(dimethylamino)carbonyl]oxy]-1-methyl- |
| Molecular Formula | C9H13BrN2O2 |
| Molecular Weight | 261.12 |
| Purity | 98 |
| Density | 0.9613 g/cm3 (20ºC) |
| Boiling Point | 88 (25 torr) |
| Melting Point | 154 °C |
| Appearance | Light yellow to colorless liquid |
| Storage Condition | Store in a sealed, cool, dry and dark place. |
| Packaging | II |
| Application | Pyridostigmine is a reversible cholinesterase inhibitor. |
| MDL Number | MFCD00079283 |
| SMILES | [Br-].CN(C)C(=O)Oc1ccc[n+](C)c1 |
| InChI | 1S/C9H13N2O2.BrH/c1-10(2)9(12)13-8-5-4-6-11(3)7-8;/h4-7H,1-3H3;1H/q+1;/p-1 |
| InChI Key | VNYBTNPBYXSMOO-UHFFFAOYSA-M |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/4434_1_101_26_8.pdf |
| Bioactivity | Pyridostigmine is a parasympathomimetic and a reversible cholinesterase inhibitor.Target: AChEPyridostigmine is a parasympathomimetic and a reversible cholinesterase inhibitor. Since it is a quaternary amine, it is poorly absorbed in the gut and does not cross the blood-brain barrier, except possibly in stressful conditions. Pyridostigmine inhibits acetylcholinesterase in the synaptic cleft, thus slowing down the hydrolysis of acetylcholine. It is a quaternary carbamate inhibitor of cholinesterase that does not cross the blood-brain barrier which carbamylates about 30% of peripheral cholinesterase enzyme. The carbamylated enzyme eventually regenerates by natural hydrolysis and excess ACh levels revert to normal.Pyridostigmine is used to treat muscle weakness in people with myasthenia gravis and to combat the effects of curariform drug toxicity. Pyridostigmine bromide has been FDA approved for military use during combat situations as an agent to be given prior to exposure to the nerve agent Soman in order to increase survival. Used in particular during the first Gulf War, pyridostigmine bromide has been implicated as a causal factor in Gulf War syndrome. Pyridostigmine sometimes is used to treat orthostatic hypotension. It may also be of benefit in chronic axonal polyneuropathy. Related Catalog Signaling Pathways >> Neuronal Signaling >> AChE Research Areas >> Neurological Disease References [1]. Gales BJ, et al. Pyridostigmine in the treatment of orthostatic intolerance. Ann Pharmacother. 2007 Feb;41(2):314-8. Epub 2007 Feb 6. [2]. Kanjwal K, et al. Pyridostigmine in the treatment of postural orthostatic tachycardia: a single-center experience. Pacing Clin Electrophysiol. 2011 Jun;34(6):750-5. Chemical & Physical Properties Density 0.9613 g/cm3 (20ºC) Boiling Point 88 (25 torr) Melting Point 154 °C Molecular Formula C9H13BrN2O2 Molecular Weight 261.116 Exact Mass 260.016022 PSA 33.42000 Index of Refraction 1.48 (20ºC) InChIKey VNYBTNPBYXSMOO-UHFFFAOYSA-M SMILES CN(C)C(=O)Oc1ccc[n+](C)c1.[Br-] Storage condition Refrigerator |
| Use of | Pyridostigmine is a parasympathomimetic and a reversible cholinesterase inhibitor.Target: AChEPyridostigmine is a parasympathomimetic and a reversible cholinesterase inhibitor. Since it is a quaternary amine, it is poorly absorbed in the gut and does not cross the blood-brain barrier, except possibly in stressful conditions. Pyridostigmine inhibits acetylcholinesterase in the synaptic cleft, thus slowing down the hydrolysis of acetylcholine. It is a quaternary carbamate inhibitor of cholinesterase that does not cross the blood-brain barrier which carbamylates about 30% of peripheral cholinesterase enzyme. The carbamylated enzyme eventually regenerates by natural hydrolysis and excess ACh levels revert to normal.Pyridostigmine is used to treat muscle weakness in people with myasthenia gravis and to combat the effects of curariform drug toxicity. Pyridostigmine bromide has been FDA approved for military use during combat situations as an agent to be given prior to exposure to the nerve agent Soman in order to increase survival. Used in particular during the first Gulf War, pyridostigmine bromide has been implicated as a causal factor in Gulf War syndrome. Pyridostigmine sometimes is used to treat orthostatic hypotension. It may also be of benefit in chronic axonal polyneuropathy. Properties Articles37 Name Mestinon Synonym More Synonyms pyridostigmine bromide Biological Activity Description Pyridostigmine is a parasympathomimetic and a reversible cholinesterase inhibitor.Target: AChEPyridostigmine is a parasympathomimetic and a reversible cholinesterase inhibitor. Since it is a quaternary amine, it is poorly absorbed in the gut and does not cross the blood-brain barrier, except possibly in stressful conditions. Pyridostigmine inhibits acetylcholinesterase in the synaptic cleft, thus slowing down the hydrolysis of acetylcholine. It is a quaternary carbamate inhibitor of cholinesterase that does not cross the blood-brain barrier which carbamylates about 30% of peripheral cholinesterase enzyme. The carbamylated enzyme eventually regenerates by natural hydrolysis and excess ACh levels revert to normal.Pyridostigmine is used to treat muscle weakness in people with myasthenia gravis and to combat the effects of curariform drug toxicity. Pyridostigmine bromide has been FDA approved for military use during combat situations as an agent to be given prior to exposure to the nerve agent Soman in order to increase survival. Used in particular during the first Gulf War, pyridostigmine bromide has been implicated as a causal factor in Gulf War syndrome. Pyridostigmine sometimes is used to treat orthostatic hypotension. It may also be of benefit in chronic axonal polyneuropathy. Related Catalog Signaling Pathways >> Neuronal Signaling >> AChE Research Areas >> Neurological Disease References [1]. Gales BJ, et al. Pyridostigmine in the treatment of orthostatic intolerance. Ann Pharmacother. 2007 Feb;41(2):314-8. Epub 2007 Feb 6. [2]. Kanjwal K, et al. Pyridostigmine in the treatment of postural orthostatic tachycardia: a single-center experience. Pacing Clin Electrophysiol. 2011 Jun;34(6):750-5. Chemical & Physical Properties Molecular Formula C9H13BrN2O2 Exact Mass 260.016022 PSA 33.42000 Index of Refraction 1.48 (20ºC) InChIKey VNYBTNPBYXSMOO-UHFFFAOYSA-M Storage condition Refrigerator |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: Item 1 Poisons. UN number: 2811 Proper Shipping Name: Toxic Solid, Organic, Not Otherwise Specified Packing grade: II |
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