CAS Number54910-89-3
SynonymsAdofen; MFCD00072041; AURORA KA-7692; Reneuron; Fluctin; Foxetin; Fluoxeren; Fluval; fluoxetina; EINECS 611-209-7
Molecular FormulaC17H18O1N1F3
Molecular Weight309.33
Purity98.00%
Density1.2±0.1 g/cm3
Boiling Point395.1±42.0 °C at 760 mmHg
Melting Point158ºC
AppearanceColorless to light yellow to yellow to brown liquid or oil
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 54910-89-3 |
| Catalog No. | 2A-9044291 |
| Chinese Name | 氟西汀 |
| Synonyms | Adofen; MFCD00072041; AURORA KA-7692; Reneuron; Fluctin; Foxetin; Fluoxeren; Fluval; fluoxetina; EINECS 611-209-7 |
| Molecular Formula | C17H18O1N1F3 |
| Molecular Weight | 309.33 |
| Purity | 98.00 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 395.1±42.0 °C at 760 mmHg |
| Melting Point | 158ºC |
| Appearance | Colorless to light yellow to yellow to brown liquid or oil |
| Storage Condition | room temperature |
| Packaging | III |
| Application | Fluoxetine (LY110140) is a selective serotonin reuptake inhibitor (SSRI). |
| HTC | 29036990 |
| PubChem ID | 143844 |
| MDL Number | MFCD00072041 |
| SMILES | CNCCC(Oc1ccc(C(F)(F)F)cc1)c1ccccc1 |
| InChI | InChI=1S/C17H18F3NO/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20/h2-10,16,21H,11-12H2,1H3 |
| InChI Key | RTHCYVBBDHJXIQ-UHFFFAOYSA-N |
| Hazard Symbols | 8 |
| MSDS | msds/44291_1_54910_89_3.pdf |
| Use of | Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) class used for antidepressant research. Properties Name Fluoxetine Synonym More Synonyms Fluoxetine Biological Activity Description Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) class used for antidepressant research. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Neuronal Signaling >> Serotonin Transporter Research Areas >> Neurological Disease In Vitro Fluoxetine blocks the downregulation of cell proliferation resulting from inescapable shock (IS) of hippocampal cell[1]. Fluoxetine increases the number of newborn cells in the dentate gyrus of the hippocampus of adult rat. Fluoxetine also increases the number of proliferating cells in the prelimbic cortex[2]. Fluoxetine accelerates the maturation of immature neurons. Fluoxetine enhances neurogenesis-dependent long-term potentiation (LTP) in the dentate gyrus[3]. Fluoxetine, but not citalopram, fluvoxamine, paroxetine and sertraline, increases norepinephrine and dopamine extracellular levels in prefrontal cortex. Fluoxetine produces robust and sustained increases in extracellular concentrations of norepinephrine and dopamine after acute systemic administration[4]. References [1]. Malberg JE, et al. Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment. Neuropsychopharmacology. 2003 Sep;28(9):1562-71 [2]. Kodama M, et al. Chronic olanzapine or fluoxetine administration increases cell proliferation in hippocampus and prefrontal cortex of adult rat. Biol Psychiatry. 2004 Oct 15;56(8):570-80. [3]. Wang JW, et al. Chronic fluoxetine stimulates maturation and synaptic plasticity of adult-born hippocampal granule cells. J Neurosci. 2008 Feb 6;28(6):1374-84. [4]. Bymaster FP, et al. Fluoxetine, but not other selective serotonin uptake inhibitors, increases norepinephrine and dopamine extracellular levels in prefrontal cortex. Psychopharmacology (Berl). 2002 Apr;160(4):353-61 [5]. Zhang W, et al. Synergistic effects of olanzapine and other antipsychotic agents in combination with fluoxetine on norepinephrine and dopamine release in rat prefrontal cortex. Neuropsychopharmacology. 2000 Sep;23(3):250-62. [6]. Avitsur R1. Increased symptoms of illness following prenatal stress: Can it be prevented by fluoxetine? Behav Brain Res. 2017 Jan 15;317:62-70. Chemical & Physical Properties Molecular Formula C17H18F3NO Exact Mass 309.134064 PSA 21.26000 Index of Refraction 1.511 InChIKey RTHCYVBBDHJXIQ-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Benzenepropanamine, N-methyl-gamma-(4-(trifluoromethyl)phenoxy)-, (+-)- CAS REGISTRY NUMBER : 54910-89-3 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C17-H18-F3-N-O MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Human - woman DOSE/DURATION : TOXIC EFFECTS : Nutritional and Gross Metabolic - other changes REFERENCE : AJPSAO American Journal of Psychiatry. (American Psychiatric Assoc., Circulation Dept., 1400 K St., NW, Washington, DC 20005) V.78- 1921- Volume(issue)/page/year: 153,134,1996 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Human - woman DOSE/DURATION : TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) REFERENCE : JCPYDR Journal of Clinical Pyschopharmacology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1981- Volume(issue)/page/year: 10,343,1990 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Human - woman DOSE/DURATION : 16800 ug/kg/6W-I TOXIC EFFECTS : Behavioral - muscle weakness Behavioral - antipsychotic Nutritional and Gross Metabolic - other changes REFERENCE : AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1908- Volume(issue)/page/year: 156,681,1996 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Human - woman DOSE/DURATION : TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - other changes REFERENCE : AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1908- Volume(issue)/page/year: 156,681,1996 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 87500 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SEX/DURATION : female 13-20 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - biochemical and metabolic REFERENCE : Safety Information Hazard Codes C,Xi WGK Germany 2 Packaging Group III Hazard Class 8 HS Code 29036990 Precursor & DownStream Precursor 9 CAS#:42142-52-9 3-Hydroxy-N-met... CAS#:98-56-6 4-Chlorobenzotr... CAS#:204704-95-0 Ethyl N-methyl-... CAS#:402-45-9 4-Trifluorometh... DownStream 2 CAS#:56296-78-7 Fluoxetine Hydr... CAS#:114247-09-5 R-Fluoxetine hy... |
| Transport Info | Product Name: Fluoxetine |
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