CAS Number53902-12-8
Synonyms2-({(2E)-3-[3,4-bis(methyloxy)phenyl]prop-2-enoyl}amino)benzoic acid; 2-{[(2E)-3-(3,4-Dimethoxyphenyl)prop-2-enoyl]amino}benzoic acid; (E)-2-(3-(3,4-dimethoxyphenyl)acrylamido)benzoic acid; 2-{[(2E)-3-(3,4-Dimethoxyphenyl)-2-propenoyl]amino}benzoic acid; N-(3,4-Dimethoxycinnamoyl)anthranilic Acid; 2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl]amino]benzoic Acid; Tranilast; rizaben; Rizaben,MK 341,Tranpro; MFCD00864787; MK 341; Tranpro
Molecular FormulaC18H17NO5
Molecular Weight327.33
Purity98.00%
Density1.3±0.1 g/cm3
Boiling Point585.5±50.0 °C at 760 mmHg
Melting Point166-168ºC
AppearanceWhite with light yellow crystalline powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 53902-12-8 |
| Catalog No. | 2A-9044075 |
| Chinese Name | 曲尼司特 |
| Synonyms | 2-({(2E)-3-[3,4-bis(methyloxy)phenyl]prop-2-enoyl}amino)benzoic acid; 2-{[(2E)-3-(3,4-Dimethoxyphenyl)prop-2-enoyl]amino}benzoic acid; (E)-2-(3-(3,4-dimethoxyphenyl)acrylamido)benzoic acid; 2-{[(2E)-3-(3,4-Dimethoxyphenyl)-2-propenoyl]amino}benzoic acid; N-(3,4-Dimethoxycinnamoyl)anthranilic Acid; 2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl]amino]benzoic Acid; Tranilast; rizaben; Rizaben,MK 341,Tranpro; MFCD00864787; MK 341; Tranpro |
| Molecular Formula | C18H17NO5 |
| Molecular Weight | 327.33 |
| Purity | 98.00 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 585.5±50.0 °C at 760 mmHg |
| Melting Point | 166-168ºC |
| Appearance | White with light yellow crystalline powder |
| Water Solubility | DMSO: 18 mg/mL |
| Storage Condition | Sealed, store at 2 ºC -8 ºC |
| Application | Tranilast is an anti-allergic compound. |
| PubChem ID | 855567 |
| SMILES | COc1ccc(C=CC(=O)Nc2ccccc2C(=O)O)cc1OC |
| InChI | InChI=1S/C18H17NO5/c1-23-15-9-7-12(11-16(15)24-2)8-10-17(20)19-14-6-4-3-5-13(14)18(21)22/h3-11H,1-2H3,(H,19,20)(H,21,22)/b10-8+ |
| InChI Key | NZHGWWWHIYHZNX-CSKARUKUSA-N |
| Hazard Symbols | transportation |
| Bioactivity | Tranilast is an antiallergic agent.Target: Angiotensin ReceptorTranilast has been approved in Japan and South Korea, since 1982, for the treatment of bronchial asthma, with indications for keloids and hypertrophic scar added in 1993. Tranilast is also used to treat asthma, autoimmune diseases, atopic and fibrotic pathologies, and can also inhibit angiogenesis. The antiproliferative properties of tranilast were found that tranilast elicited an inhibitory effect on fibroblast proliferation in vitro and also suppressed collagen production both in vitro and in vivo . Tranilast also reduced the release of chemical mediators from mast cells and suppressed hypersensitivity reactions. [1]Three-week-old C57Bl/10 and mdx mice received tranilast (~300 mg/kg) in their food for 9 weeks, after which fibrosis was assessed through histological analyses, and functional properties of tibialis anterior muscles were assessed in situ and diaphragm muscle strips in vitro. Tranilast administration did not significantly alter the mass of any muscles in control or mdx mice, but it decreased fibrosis in the severely affected diaphragm muscle by 31% compared with untreated mdx mice (P< 0.05) [2]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Angiotensin Receptor Research Areas >> Inflammation/Immunology References [1]. Rogosnitzky, M., R. Danks, and E. Kardash, Therapeutic potential of tranilast, an anti-allergy drug, in proliferative disorders. Anticancer Res, 2012. 32(7): p. 2471-8. [2]. Swiderski, K., et al., Tranilast administration reduces fibrosis and improves fatigue resistance in muscles of mdx dystrophic mice. Fibrogenesis Tissue Repair, 2014. 7(1): p. 1. [3]. Huang L, et al. Sinomenine-induced histamine release-like anaphylactoid reactions are blocked by tranilast via inhibiting NF-κB signaling. Pharmacol Res. 2017 Aug 31. pii: S1043-6618(17)30796-X. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 585.5±50.0 °C at 760 mmHg Melting Point 166-168ºC Molecular Formula C18H17NO5 Molecular Weight 327.331 Flash Point 307.9±30.1 °C Exact Mass 327.110687 PSA 84.86000 LogP 4.36 Vapour Pressure 0.0±1.7 mmHg at 25°C Index of Refraction 1.648 InChIKey NZHGWWWHIYHZNX-CSKARUKUSA-N SMILES COc1ccc(C=CC(=O)Nc2ccccc2C(=O)O)cc1OC Storage condition 2-8°C Water Solubility DMSO: 18 mg/mL |
| Use of | Properties Articles49 Name tranilast Synonym More Synonyms Tranilast Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> Angiotensin Receptor Research Areas >> Inflammation/Immunology References [1]. Rogosnitzky, M., R. Danks, and E. Kardash, Therapeutic potential of tranilast, an anti-allergy drug, in proliferative disorders. Anticancer Res, 2012. 32(7): p. 2471-8. [2]. Swiderski, K., et al., Tranilast administration reduces fibrosis and improves fatigue resistance in muscles of mdx dystrophic mice. Fibrogenesis Tissue Repair, 2014. 7(1): p. 1. [3]. Huang L, et al. Sinomenine-induced histamine release-like anaphylactoid reactions are blocked by tranilast via inhibiting NF-κB signaling. Pharmacol Res. 2017 Aug 31. pii: S1043-6618(17)30796-X. Chemical & Physical Properties Molecular Formula C18H17NO5 Exact Mass 327.110687 PSA 84.86000 Index of Refraction 1.648 InChIKey NZHGWWWHIYHZNX-CSKARUKUSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip. |
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