CAS Number50594-66-6
SynonymsEINECS 256-634-5; 5-[2-Chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoic acid; Acifluorfen ∆; WNR BVQ DOR BG DXFFF; Acifluorofen; 5-(2-Chloro-4-(trifluoromethyl)phenoxy)-2-nitrobenzoic acid; 5-(2-chloro-α,α,α-trifluoro-p-tolyloxy)-2-nitrobenzoic acid; 5-{[2-Chloro-4-(trifluoromethyl)phenyl]oxy}-2-nitrobenzoic acid; 5-(2-Chloro-4-trifluoromethylphenoxy)-2-nitrobenzoic acid; Acifluorfen; MFCD00143541
Molecular FormulaC14H7ClF3NO5
Molecular Weight361.66
Purity98.00%
Density1.6±0.1 g/cm3
Boiling Point422.4±45.0 °C at 760 mmHg
Melting Point161ºC
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 50594-66-6 |
| Catalog No. | 2A-9043278 |
| Chinese Name | 三氟羧草醚 |
| Synonyms | EINECS 256-634-5; 5-[2-Chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoic acid; Acifluorfen ∆; WNR BVQ DOR BG DXFFF; Acifluorofen; 5-(2-Chloro-4-(trifluoromethyl)phenoxy)-2-nitrobenzoic acid; 5-(2-chloro-α,α,α-trifluoro-p-tolyloxy)-2-nitrobenzoic acid; 5-{[2-Chloro-4-(trifluoromethyl)phenyl]oxy}-2-nitrobenzoic acid; 5-(2-Chloro-4-trifluoromethylphenoxy)-2-nitrobenzoic acid; Acifluorfen; MFCD00143541 |
| Molecular Formula | C14H7ClF3NO5 |
| Molecular Weight | 361.66 |
| Purity | 98.00 |
| Density | 1.6±0.1 g/cm3 |
| Boiling Point | 422.4±45.0 °C at 760 mmHg |
| Melting Point | 161ºC |
| Storage Condition | Sealed, store at 2 ºC -8 ºC |
| Packaging | III |
| Application | Acifluorfen is a protoporphyrinogen oxidase (PROTOX) inhibitor herbicide that promotes the accumulation of protoporphyrin IX (PPIX) and induces liver tumors in rodents. Acifluorfen causes intense phot |
| HTC | 2918990027 |
| PubChem ID | 4621238 |
| SMILES | O=C(O)c1cc(Oc2ccc(C(F)(F)F)cc2Cl)ccc1[N+](=O)[O-] |
| InChI | InChI=1S/C14H7ClF3NO5/c15-10-5-7(14(16,17)18)1-4-12(10)24-8-2-3-11(19(22)23)9(6-8)13(20)21/h1-6H,(H,20,21) |
| InChI Key | NUFNQYOELLVIPL-UHFFFAOYSA-N |
| Hazard Symbols | transportation |
| Bioactivity | Acifluorfen, a protoporphyrinogen oxidase (PROTOX) inhibitor herbicide, promotes the accumulation of protoporphyrin IX (PPIX), and induces tumors in the rodent liver. Acifluorfen causes strong photooxidative destruction of pigments and lipids in sensitive plant species[1][2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Others >> Others In Vitro The effect of Acifluorfen on glutathione and ascorbate levels in cucumber (Cucumis sativus L.) cotyledon discs is investigated to assess the relationship between herbicide activity and endogenous antioxidants. Acifluorfen decreases the levels of glutathione and ascorbate over 50% in discs exposed to less than 1.5 hours of white light (450 microeinsteins per square meter per second). Acifluorfen also causes the rapid depletion of ascorbate in far-red light grown plants which are photosynthetically incompetent[2]. In Vivo Dietary treatment with 2500 ppm Acifluorfen for up to 13 weeks increases Cyp2b10 expression in the livers of wild-type mice, but not in CAR-knockout (CARKO) mice. Microscopically, Acifluorfen treatment-induces cytotoxic changes, including hepatocellular necrosis and inflammation, and causes regenerative changes accompanied by prolonged increases in the numbers of proliferating cell nuclear antigen-positive hepatocytes in WT mice[1]. References [1]. Kuwata K, et al. Involvement of Mouse Constitutive Androstane Receptor in Acifluorfen-Induced Liver Injury and Subsequent Tumor Development. Toxicol Sci. 2016;151(2):271-285. [2]. Kenyon WH, et al. Effects of Acifluorfen on Endogenous Antioxidants and Protective Enzymes in Cucumber (Cucumis sativus L.) Cotyledons. Plant Physiol. 1985;79(3):862-866. Chemical & Physical Properties Density 1.6±0.1 g/cm3 Boiling Point 422.4±45.0 °C at 760 mmHg Melting Point 161ºC Molecular Formula C14H7ClF3NO5 Molecular Weight 361.657 Flash Point 209.2±28.7 °C Exact Mass 360.996490 PSA 92.35000 LogP 4.35 Vapour Pressure 0.0±1.1 mmHg at 25°C Index of Refraction 1.576 InChIKey NUFNQYOELLVIPL-UHFFFAOYSA-N SMILES O=C(O)c1cc(Oc2ccc(C(F)(F)F)cc2Cl)ccc1[N+](=O)[O-] Storage condition 0-6°C |
| Use of | Acifluorfen, a protoporphyrinogen oxidase (PROTOX) inhibitor herbicide, promotes the accumulation of protoporphyrin IX (PPIX), and induces tumors in the rodent liver. Acifluorfen causes strong photooxidative destruction of pigments and lipids in sensitive plant species[1][2]. Properties Articles26 Name acifluorfen Synonym More Synonyms Acifluorfen Biological Activity Description Acifluorfen, a protoporphyrinogen oxidase (PROTOX) inhibitor herbicide, promotes the accumulation of protoporphyrin IX (PPIX), and induces tumors in the rodent liver. Acifluorfen causes strong photooxidative destruction of pigments and lipids in sensitive plant species[1][2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Others >> Others In Vivo Dietary treatment with 2500 ppm Acifluorfen for up to 13 weeks increases Cyp2b10 expression in the livers of wild-type mice, but not in CAR-knockout (CARKO) mice. Microscopically, Acifluorfen treatment-induces cytotoxic changes, including hepatocellular necrosis and inflammation, and causes regenerative changes accompanied by prolonged increases in the numbers of proliferating cell nuclear antigen-positive hepatocytes in WT mice[1]. References [1]. Kuwata K, et al. Involvement of Mouse Constitutive Androstane Receptor in Acifluorfen-Induced Liver Injury and Subsequent Tumor Development. Toxicol Sci. 2016;151(2):271-285. [2]. Kenyon WH, et al. Effects of Acifluorfen on Endogenous Antioxidants and Protective Enzymes in Cucumber (Cucumis sativus L.) Cotyledons. Plant Physiol. 1985;79(3):862-866. Chemical & Physical Properties Exact Mass 360.996490 PSA 92.35000 Index of Refraction 1.576 InChIKey NUFNQYOELLVIPL-UHFFFAOYSA-N |
| Tax Rebate | 9.0% |
| Supervision | S. Import and export pesticide registration certificate |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Danger Regulations: 3077 International Maritime Transport Danger Regulations: 3077 International Air Transport Danger Regulations: 3077 14.2 Names specified by the United Nations (UN) European land transport hazard regulations: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (Acifluorfen) IMDG Code: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (Acifluorfen) International air transport hazard regulations: Environmentally hazardous substance, solid, n.o.s. (Acifluorfen) 14.3 Transport hazard categories European land transport Dangerous Regulations: 9 International sea transport Dangerous Regulations: 9 International air transport Dangerous Regulations: 9 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Dangerous Regulations: Yes International Maritime Transport Dangerous Regulations Maritime Pollutants: Yes International Air Transport Dangerous Regulations: Yes 14.6 Special reminder to users further information Dangerous goods are individually packaged, with liquids exceeding 5 liters or solids exceeding 5 kilograms. The outer packaging of each independent package and the combined independent inner package must have EHS on it. Identification (according to European ADR Regulation 2.2.9.1.10, IMDG Regulation 2.10.3), |
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