| Chemical & Physical Properties | |
|---|---|
| CAS Number | 41708-72-9 |
| Catalog No. | 2A-9042839 |
| Chinese Name | 2-氨基-N-(2,6-二甲基苯基)丙酰胺 |
| Synonyms | R/S-Tocainide; 2-amino-2',6'-propionoxylidide; MFCD00072010; EINECS 255-505-0; TOCAINIDE; 6'-propionoxylidide,2-amino-2; alanyl-2,6-xylidide |
| Molecular Formula | C11H16O1N2 |
| Molecular Weight | 192.26 |
| Purity | 98.00 |
| Storage Condition | 2-8°C |
| Application | Trocononide hydrochloride is an orally active sodium channel blocker that blocks sodium channels at the pain-generating site on the neural membrane. Tocononide hydrochloride is a primary amine analog |
| HTC | 2924299090 |
| PubChem ID | 9351 |
| MDL Number | MFCD00072010 |
| SMILES | Cc1cccc(C)c1NC(=O)C(C)N |
| InChI | InChI=1S/C11H16N2O/c1-7-5-4-6-8(2)10(7)13-11(14)9(3)12/h4-6,9H,12H2,1-3H3,(H,13,14) |
| InChI Key | BUJAGSGYPOAWEI-UHFFFAOYSA-N |
| MSDS | msds/42839_1_41708_72_9.pdf |
| Use of | Tocainide hydrochloride is an orally activesodium channel blocker, it blocks the sodium channels in the pain-producing foci in the nerve membranes. Tocainide hydrochloride is a primary amine analog of lidocaine, can be used for the treatment of tinnitus[1][2]. Properties Name tocainide Synonym More Synonyms Tocainide Biological Activity Description Tocainide hydrochloride is an orally activesodium channel blocker, it blocks the sodium channels in the pain-producing foci in the nerve membranes. Tocainide hydrochloride is a primary amine analog of lidocaine, can be used for the treatment of tinnitus[1][2]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Cardiovascular Disease IC50: sodium channel[1] References [1]. Alpert JS, et al. Chemistry, pharmacology, antiarrhythmic efficacy and adverse effects of tocainide hydrochloride, an orally active structural analog of lidocaine. Pharmacotherapy. 1983 Nov-Dec;3(6):316-23. [2]. De Luca A,et al.Optimal requirements for high affinity and use-dependent block of skeletal muscle sodium channel by N-benzyl analogs of tocainide-like compounds.Mol Pharmacol. 2003 Oct;64(4):932-45. Chemical & Physical Properties Molecular Formula C11H16N2O Exact Mass 192.12600 PSA 55.12000 LogP 2.36240 InChIKey BUJAGSGYPOAWEI-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 2',6'-Propionoxylidide, 2-amino- CAS REGISTRY NUMBER : 41708-72-9 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C11-H16-N2-O MOLECULAR WEIGHT : WISWESSER LINE NOTATION : ZY1&VMR B1 F1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Human - man DOSE/DURATION : TOXIC EFFECTS : Behavioral - coma Cardiac - cardiomyopathy including infarction REFERENCE : BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 288,760,1984 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : DOSE/DURATION : 5714 ug/kg TOXIC EFFECTS : Behavioral - hallucinations, distorted perceptions Gastrointestinal - nausea or vomiting REFERENCE : TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Human - man DOSE/DURATION : TOXIC EFFECTS : Blood - aplastic anemia REFERENCE : NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year: 314,583,1986 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Peripheral Nerve and Sensation - local anesthetic Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,1059,1981 Safety Information Hazard Codes Xn: Harmful; Risk Phrases R22 HS Code 2924299090 Synthetic Route Total: 1 Page 2-Bromo-N-(2,6-... CAS#:41708-73-0 CAS#:41708-72-9 Literature: Astra Pharmaceutical Products, Inc. Patent: US4218477 A1, 1980 ; US 4218477 A 2-CHLORO-N-(2,6... CAS#:36292-29-2 CAS#:41708-72-9 Literature: Astra Pharmaceutical Products, Inc. Patent: US4218477 A1, 1980 ; US 4218477 A 2-phthalimidopr... CAS#:71344-61-1 2,3-Dihydrophth... CAS#:1445-69-8 CAS#:41708-72-9 Literature: Tenthorey; Block; Ronfeld; McMaster; Byrnes Journal of Medicinal Chemistry, 1981 , vol. 24, # 7 p. 798 - 806 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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