CAS Number40126-30-5
SynonymsH-cis-Hyp-OMe.HCl; Methyl (4S)-4-hydroxy-L-prolinate hydrochloride (1:1); Trans-4-hydroxy-L-proline methyl ester hydrochloride; Methyl (4R)-4-hydroxy-L-prolinate hydrochloride (1:1); L-Proline, 4-hydroxy-, methyl ester, (4S)-, hydrochloride (1:1); L-Proline, 4-hydroxy-, methyl ester, (4R)-, hydrochloride (1:1); (2S,4S)-Methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride; methyl (2S,4S)-4-hydroxypyrrolidine-2-carboxylate,hydrochloride; cis-4-Hydroxy-L-proline methyl ester hydrochloride
Molecular FormulaC6H12ClNO3
Molecular Weight181.617
Purity98.00%
Boiling Point282.3ºC at 760 mmHg
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 40126-30-5 |
| Catalog No. | 2A-0202265 |
| Chinese Name | CIS-4-羟基-L-脯氨酸甲基酯盐酸盐 |
| Synonyms | H-cis-Hyp-OMe.HCl; Methyl (4S)-4-hydroxy-L-prolinate hydrochloride (1:1); Trans-4-hydroxy-L-proline methyl ester hydrochloride; Methyl (4R)-4-hydroxy-L-prolinate hydrochloride (1:1); L-Proline, 4-hydroxy-, methyl ester, (4S)-, hydrochloride (1:1); L-Proline, 4-hydroxy-, methyl ester, (4R)-, hydrochloride (1:1); (2S,4S)-Methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride; methyl (2S,4S)-4-hydroxypyrrolidine-2-carboxylate,hydrochloride; cis-4-Hydroxy-L-proline methyl ester hydrochloride |
| Molecular Formula | C6H12ClNO3 |
| Molecular Weight | 181.617 |
| Purity | 98.00 |
| Boiling Point | 282.3ºC at 760 mmHg |
| Storage Condition | Sealed and stored at 2 ºC -10 ºC |
| Application | H-cis-Hyp-OMe hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody drug conjugates (ADC). H-cis-Hyp-OMe hydrochloride is also an alkyl chain-based PROTAC linker that can be us |
| PubChem ID | 99008621 |
| SMILES | COC(=O)C1CC(O)CN1.Cl |
| InChI | InChI=1S/C6H11NO3.ClH/c1-10-6(9)5-2-4(8)3-7-5;/h4-5,7-8H,2-3H2,1H3;1H/t4-,5-;/m0./s1 |
| InChI Key | KLGSHNXEUZOKHH-FHAQVOQBSA-N |
| MSDS | msds/42502_1_40126_30_5.pdf |
| Bioactivity | H-cis-Hyp-OMe hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). H-cis-Hyp-OMe hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PR Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker Target Non-cleavable In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. References [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. Chemical & Physical Properties Boiling Point 282.3ºC at 760 mmHg Molecular Formula C6H12ClNO3 Molecular Weight 181.617 Flash Point 124.5ºC Exact Mass 181.050568 PSA 58.56000 LogP 0.01300 InChIKey KLGSHNXEUZOKHH-FHAQVOQBSA-N SMILES COC(=O)C1CC(O)CN1.Cl Storage condition 2-8°C |
| Use of | H-cis-Hyp-OMe hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). H-cis-Hyp-OMe hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PR Properties Name H-Cis-Hyp-Ome Hcl Synonym More Synonyms H-cis-Hyp-OMe hydrochloride Biological Activity Description H-cis-Hyp-OMe hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). H-cis-Hyp-OMe hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PR Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker Non-cleavable In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. References [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. Chemical & Physical Properties Exact Mass 181.050568 PSA 58.56000 LogP 0.01300 InChIKey KLGSHNXEUZOKHH-FHAQVOQBSA-N |
| Transport Info | Product name: cis-4-Hydroxy-L-proline methyl ester hydrochloride |
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