| Chemical & Physical Properties | |
|---|---|
| CAS Number | 39011-90-0 |
| Catalog No. | 2A-9042244 |
| Chinese Name | 芍药内酯苷 |
| Synonyms | Paeonia lactiflora Pall.; Alibiflorin; albiflorin |
| Molecular Formula | C23H28O11 |
| Molecular Weight | 480.46 |
| Purity | 98.00 |
| Density | 1.6±0.1 g/cm3 |
| Boiling Point | 722.1±60.0 °C at 760 mmHg |
| Appearance | white powder |
| Storage Condition | ?20°C |
| Application | Albiflorin is a component extracted from peony roots and has therapeutic potential for neurodegenerative diseases. |
| PubChem ID | 50113908 |
| SMILES | CC12CC(O)C3CC1(OC1OC(CO)C(O)C(O)C1O)C3(COC(=O)c1ccccc1)C(=O)O2 |
| InChI | InChI=1S/C23H28O11/c1-21-8-13(25)12-7-23(21,33-19-17(28)16(27)15(26)14(9-24)32-19)22(12,20(30)34-21)10-31-18(29)11-5-3-2-4-6-11/h2-6,12-17,19,24-28H,7-10H2,1H3/t12?,13?,14-,15-,16+,17-,19+,21?,22?,23?/m1/s1 |
| InChI Key | QQUHMASGPODSIW-ICECTASOSA-N |
| Hazard Symbols | transportation |
| Bioactivity | Albiflorin is a major constituent contained in peony root; possesses therapeutic potential for neurodegenerative diseases.IC50 value:Target: in vitro: Albiflorin significantly ameliorated Glu-induced reduction of cell viability, nuclear and mitochondrial apoptotic alteration, reactive oxygen species accumulation, and B-cell lymphoma 2 (Bcl-2)/Bax ratio. Albiflorin also enhanced phosphorylation of AKT and its downstream element glycogen synthase kinase-3β, and this effect was abrogated by the AKT inhibitor LY294002 [1]. in vivo: Mice were exposed to X-ray radiation (400 Roentgen), and both mice and rabbits were intraperitoneally injected with cyclophosphamide (100.0 mg/kg) and cytarabine chloride (92.7 mg/kg), respectively, for 3 days to induce myelosuppression. Albiflorin was subsequently administrated intravenously at low (15.0 mg/kg for mice, 6.00 mg/kg for rabbits), intermediate (30.0 mg/kg for mice, 12.0 mg/kg for rabbits) and high (60.0 mg/kg for mice, 24.0 mg/kg for rabbits) doses, as well as orally (60.0 mg/kg for mice, 24.0 mg/kg for rabbits) for 7 days. Shenqi tablets were used as positive controls (oral administration of 936.0 mg/kg for mice, 336.0 mg/kg for rabbits). The administration of Albiflorin significantly ameliorated myelosuppression in all cases [2]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Natural Products >> Terpenoids and Glycosides References [1]. Wang D, et al. Neuroprotective effects of paeoniflorin, but not the isomer albiflorin, are associated with the suppression of intracellular calcium and calcium/calmodulin protein kinase II in PC12 cells. J Mol Neurosci. 2013 Oct;51(2):581-90. [2]. Xu W, et al. Therapeutic effects of combination of paeoniflorin and albiflorin from Paeonia radix on radiation and chemotherapy-induced myelosuppression in mice and rabbits. Asian Pac J Cancer Prev. 2011;12(8):2031-7. Chemical & Physical Properties Density 1.6±0.1 g/cm3 Boiling Point 722.1±60.0 °C at 760 mmHg Molecular Formula C23H28O11 Molecular Weight 480.462 Flash Point 248.9±26.4 °C Exact Mass 480.163147 PSA 172.21000 LogP -0.97 Vapour Pressure 0.0±2.5 mmHg at 25°C Index of Refraction 1.662 InChIKey QQUHMASGPODSIW-ICECTASOSA-N SMILES CC12CC(O)C3CC1(OC1OC(CO)C(O)C(O)C1O)C3(COC(=O)c1ccccc1)C(=O)O2 Storage condition ?20°C |
| Use of | Properties Articles41 Name Albiflorin Synonym More Synonyms albiflorin Biological Activity Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Natural Products >> Terpenoids and Glycosides References [2]. Xu W, et al. Therapeutic effects of combination of paeoniflorin and albiflorin from Paeonia radix on radiation and chemotherapy-induced myelosuppression in mice and rabbits. Asian Pac J Cancer Prev. 2011;12(8):2031-7. Chemical & Physical Properties Molecular Formula C23H28O11 Exact Mass 480.163147 PSA 172.21000 LogP -0.97 Index of Refraction 1.662 InChIKey QQUHMASGPODSIW-ICECTASOSA-N |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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