CAS Number31271-07-5
Synonyms2,8-Bis(3-methyl-2-butenyl)-1,3,6,7-tetrahydroxy-9H-xanthen-9-one; gamma-mangostin; r-mangostin; 1,3,6,7-Tetrahydroxy-2,8-bis(3-methyl-2-buten-1-yl)-9H-xanthen-9-one; 1,3,6,7-tetrahydroxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one; 1,3,6,7-tetrahydroxy-2,8-bis(3-methylbut-2-enyl)xanthen-9-one; normangostin
Molecular FormulaC23H24O6
Molecular Weight396.433
Purity98.00%
Density1.3±0.1 g/cm3
Boiling Point648.4±55.0 °C at 760 mmHg
Appearanceoff-white to yellow
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 31271-07-5 |
| Catalog No. | 2A-9040863 |
| Chinese Name | γ-倒捻子素 |
| Synonyms | 2,8-Bis(3-methyl-2-butenyl)-1,3,6,7-tetrahydroxy-9H-xanthen-9-one; gamma-mangostin; r-mangostin; 1,3,6,7-Tetrahydroxy-2,8-bis(3-methyl-2-buten-1-yl)-9H-xanthen-9-one; 1,3,6,7-tetrahydroxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one; 1,3,6,7-tetrahydroxy-2,8-bis(3-methylbut-2-enyl)xanthen-9-one; normangostin |
| Molecular Formula | C23H24O6 |
| Molecular Weight | 396.433 |
| Purity | 98.00 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 648.4±55.0 °C at 760 mmHg |
| Appearance | off-white to yellow |
| Water Solubility | methanol: soluble1mg/mL, colorless to yellow |
| Storage Condition | 2-8°C |
| Application | Gamma-Mangostin is a novel competitive 5-HT2A receptors antagonist purified from the husk of the medicinal plant Garcinia mangostana. Gamma-Mangostin is an inhibitor of transthyretin (TTR) fibrillatio |
| HTC | 2932999099 |
| SMILES | CC(C)=CCc1c(O)cc2oc3cc(O)c(O)c(CC=C(C)C)c3c(=O)c2c1O |
| InChI | InChI=1S/C23H24O6/c1-11(2)5-7-13-15(24)9-18-20(22(13)27)23(28)19-14(8-6-12(3)4)21(26)16(25)10-17(19)29-18/h5-6,9-10,24-27H,7-8H2,1-4H3 |
| InChI Key | VEZXFTKZUMARDU-UHFFFAOYSA-N |
| Bioactivity | Chemical & Physical Properties |
| Use of | Gamma-Mangostin is a novel competitive 5-hydroxytryptamine 2A (5-HT2A) receptors antagonist, purified from the fruit hull of the medicinal plant Garcinia mangostana. Gamma-Mangostin is a inhibitor of Transthyretin (TTR) fibrillization, it binds to the thyroxine (T4)-binding sites and stabilized the TTR tetramer[2]. Gamma-Mangostin inhibits [3H] spiperone binding to cultured rat aortic myocytes (IC50=3.5 nM) and reduces The perfusion pressure response of rat coronary artery to 5-HT2A (IC50=0.32 µM) [1]. Properties Biological Activity Chemical & Physical Properties |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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