CAS Number22919-26-2
SynonymsSodium 4-methyl-2-oxo-2H-chromen-7-yl phosphate; 4-Methylumbelliferyl phosphate sodium salt; 4-MUP,Disodium 4-methylumbelliferyl phosphate; EINECS 245-325-0; Disodium 4-methyl-2-oxo-2H-chromen-7-yl phosphate; 2H-1-Benzopyran-2-one, 4-methyl-7-(phosphonooxy)-, sodium salt (1:2); 4-Methylumbelliferylphosphate disodium salt trihydrate; 4-MUP; 4-Methylumbelliferyl phosphate,disodium salt; MFCD00037614; Disodium 4-methylumbelliferyl phosphate
Molecular FormulaC10H7Na2O6P
Molecular Weight300.11
Purity≥98 (TLC)%
Boiling Point511.4ºC at 760 mmHg
Appearancepowder
EINECS245-325-0
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 22919-26-2 |
| Catalog No. | 2A-9039108 |
| Chinese Name | 4-甲基伞形酮磷酸酯 二钠盐 |
| Synonyms | Sodium 4-methyl-2-oxo-2H-chromen-7-yl phosphate; 4-Methylumbelliferyl phosphate sodium salt; 4-MUP,Disodium 4-methylumbelliferyl phosphate; EINECS 245-325-0; Disodium 4-methyl-2-oxo-2H-chromen-7-yl phosphate; 2H-1-Benzopyran-2-one, 4-methyl-7-(phosphonooxy)-, sodium salt (1:2); 4-Methylumbelliferylphosphate disodium salt trihydrate; 4-MUP; 4-Methylumbelliferyl phosphate,disodium salt; MFCD00037614; Disodium 4-methylumbelliferyl phosphate |
| Molecular Formula | C10H7Na2O6P |
| Molecular Weight | 300.11 |
| Purity | ≥98 (TLC) |
| Boiling Point | 511.4ºC at 760 mmHg |
| Appearance | powder |
| Storage Condition | Sealed in a cool, dry environment at -20 ºC |
| Application | Disodium 4-methylumbelliferyl phosphate (4-MUP) is an anionic organophosphate and a fluorescent substrate for acidic and alkaline phosphatases. 4-Methyl fumarate disodium is also a nerve agent mimetic |
| EINECS | 245-325-0 |
| HTC | 2932209090 |
| PubChem ID | 24897230 |
| MDL Number | MFCD00037614 |
| SMILES | [Na+].[Na+].CC1=CC(=O)Oc2cc(OP([O-])([O-])=O)ccc12 |
| InChI | 1S/C10H9O6P.2Na/c1-6-4-10(11)15-9-5-7(2-3-8(6)9)16-17(12,13)14;;/h2-5H,1H3,(H2,12,13,14);;/q;2*+1/p-2 |
| InChI Key | WUUDJQVNZPEPKN-UHFFFAOYSA-L |
| NACRES Code | NA.32 |
| UNSPSC | 12352204 |
| MSDS | msds/39108_1_22919_26_2.pdf |
| Bioactivity | 4-Methylumbelliferyl phosphate (4-MUP) disodium, an anionic organophosphate, is a acid and alkaline phosphatase fluorogenic substrate. 4-Methylumbelliferyl phosphate disodium is also a nerve agent simulant[1][2][3]. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase Research Areas >> Others In Vitro Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs). Serum acid phosphatase assay[1]: 1. Preparation a 100 μL solution containing the following agents: 5.0 μL of serum enzyme, 50 μL of 4-Methylumbelliferyl phosphate (5.0 mM), and 10 μL of 1.0 M buffer at pH 6.0. 2. Add the following agents (with the final concentration) 20 mM Sodium Tartrate (HY-128476), 15 mM Sodium Fluoride (HY-B1766), 3000 mM 2-Mercaptoethanol, 4 mM 1, 10-Phenanthroline (HY-W004544), 6 mM 8-Quinolinol (HY-B1005), 6 mM 8-Hydroxy-5quinolinesulfonic acid, 45 mM EDTA (HY-Y0682) and 6 mM EGTA (HY-D0861). 3. Incubate reaction mixtures for 15 min at 37℃ and terminated by the addition of 2.9 mL of 0.1 M ammonium hydroxide/glycine buffer, pH 10.5. 4. Mix samples thoroughly and determine fluorescence by a fluorometer. References [1]. Chambers JP, et al. Determination of serum acid phosphatase in Gaucher's disease using 4-methylumbelliferyl phosphate. Clin Chim Acta. 1977 Oct 1;80(1):67-77. [2]. Watanabe F, et al. The analysis of alkaline phosphatase isoenzyme using 4-methylumbelliferyl phosphate as substrate on a cellulose acetate membrane. Clin Chim Acta. 1979 Feb 1;91(3):273-6. [3]. Hao Chen, et al. Autonomic Molecular Transport for Ultrasensitive Surface-Enhanced Infrared Absorption Spectroscopy. ACS Appl. Polym. Mater. 2020, 2, 9, 3929-3935 Chemical & Physical Properties Boiling Point 511.4ºC at 760 mmHg Molecular Formula C10H7Na2O6P Molecular Weight 300.112 Flash Point 263.1ºC Exact Mass 299.977570 PSA 112.44000 LogP 2.44930 Vapour Pressure 2.79E-11mmHg at 25°C InChIKey WUUDJQVNZPEPKN-UHFFFAOYSA-L SMILES Cc1cc(=O)oc2cc(OP(=O)([O-])[O-])ccc12.[Na+].[Na+] Storage condition −20°C |
| Use of | 4-Methylumbelliferyl phosphate (4-MUP) disodium, an anionic organophosphate, is a acid and alkaline phosphatase fluorogenic substrate. 4-Methylumbelliferyl phosphate disodium is also a nerve agent simulant[1][2][3]. Properties Articles16 Name disodium,(4-methyl-2-oxochromen-7-yl) phosphate Synonym More Synonyms Biological Activity Description 4-Methylumbelliferyl phosphate (4-MUP) disodium, an anionic organophosphate, is a acid and alkaline phosphatase fluorogenic substrate. 4-Methylumbelliferyl phosphate disodium is also a nerve agent simulant[1][2][3]. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase Research Areas >> Others References [1]. Chambers JP, et al. Determination of serum acid phosphatase in Gaucher's disease using 4-methylumbelliferyl phosphate. Clin Chim Acta. 1977 Oct 1;80(1):67-77. [2]. Watanabe F, et al. The analysis of alkaline phosphatase isoenzyme using 4-methylumbelliferyl phosphate as substrate on a cellulose acetate membrane. Clin Chim Acta. 1979 Feb 1;91(3):273-6. [3]. Hao Chen, et al. Autonomic Molecular Transport for Ultrasensitive Surface-Enhanced Infrared Absorption Spectroscopy. ACS Appl. Polym. Mater. 2020, 2, 9, 3929-3935 Chemical & Physical Properties Molecular Formula C10H7Na2O6P Exact Mass 299.977570 PSA 112.44000 LogP 2.44930 InChIKey WUUDJQVNZPEPKN-UHFFFAOYSA-L |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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