CAS Number20724-73-6
Synonymsvalopicitabine; 2-C-METHYLCYTIDINE; 2'-C-Methyl Cytidine; Cytidine,2'-C-methyl; 2'-METHYLCYTIDINE; 2'-C-methylcytidine
Molecular FormulaC10H15N3O5
Molecular Weight257.24
Purity≥95 (HPLC)%
Density1.7±0.1 g/cm3
Boiling Point523.9±60.0 °C at 760 mmHg
Melting Point243-245ºC
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 20724-73-6 |
| Catalog No. | 2A-9038501 |
| Chinese Name | 2'-C-甲基胞嘧啶核苷 |
| Synonyms | valopicitabine; 2-C-METHYLCYTIDINE; 2'-C-Methyl Cytidine; Cytidine,2'-C-methyl; 2'-METHYLCYTIDINE; 2'-C-methylcytidine |
| Molecular Formula | C10H15N3O5 |
| Molecular Weight | 257.24 |
| Purity | ≥95 (HPLC) |
| Density | 1.7±0.1 g/cm3 |
| Boiling Point | 523.9±60.0 °C at 760 mmHg |
| Melting Point | 243-245ºC |
| Appearance | powder |
| Water Solubility | H2O: >20mg/mL |
| Storage Condition | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
| Application | NM107 inhibits HCV RNA replication with an IC50 of 7.0 μM. |
| HTC | 2934999090 |
| PubChem ID | 329817997 |
| MDL Number | MFCD02682947 |
| SMILES | C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1N2C=CC(N)=NC2=O |
| InChI | 1S/C10H15N3O5/c1-10(17)7(15)5(4-14)18-8(10)13-3-2-6(11)12-9(13)16/h2-3,5,7-8,14-15,17H,4H2,1H3,(H2,11,12,16)/t5-,7-,8-,10-/m1/s1 |
| InChI Key | PPUDLEUZKVJXSZ-VPCXQMTMSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/38501_1_20724_73_6.pdf |
| Use of | NM107 is a inhibitors of HCV RNA replication with IC50 of 7.0 μM in vitro.IC50 value: 7.0 μMTarget:HCV RNA replicationNM107 is a potent and selective inhibitor of flavi- and pesti-virus replication in cell culture, with inhibitory activity and cytotoxicity against HCV 1b replicon cells, IC50 is 1.13 μM. Intracellular HCV RNA in HCV-infected cells treated the HCV polymerase inhibitor NM107 shows a similar pattern of decline. NM107 are currently being investigated as additional therapeutic agents for HCV infection. NM107 inhibits bovine viral diarrhea virus (BVDV) replication (EC50 0.67 nM), eliminates persistent BVDV infection at nontoxic concentrations. Properties Name 4-amino-1-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]pyrimidin-2-one Synonym More Synonyms 2'-C-Methylcytidine Biological Activity Description NM107 is a inhibitors of HCV RNA replication with IC50 of 7.0 μM in vitro.IC50 value: 7.0 μMTarget:HCV RNA replicationNM107 is a potent and selective inhibitor of flavi- and pesti-virus replication in cell culture, with inhibitory activity and cytotoxicity against HCV 1b replicon cells, IC50 is 1.13 μM. Intracellular HCV RNA in HCV-infected cells treated the HCV polymerase inhibitor NM107 shows a similar pattern of decline. NM107 are currently being investigated as additional therapeutic agents for HCV infection. NM107 inhibits bovine viral diarrhea virus (BVDV) replication (EC50 0.67 nM), eliminates persistent BVDV infection at nontoxic concentrations. Related Catalog Signaling Pathways >> Anti-infection >> HCV Research Areas >> Infection References [1]. McCown MF, et al. The hepatitis C virus replicon presents a higher barrier to resistance to nucleoside analogs than to nonnucleosidepolymerase or protease inhibitors. Antimicrob Agents Chemother. 2008 May;52(5):1604-1612. Chemical & Physical Properties Molecular Formula C10H15N3O5 Exact Mass 257.101166 PSA 130.83000 LogP -0.80 Index of Refraction 1.700 InChIKey PPUDLEUZKVJXSZ-VPCXQMTMSA-N Safety Information Signal Word Warning Hazard Statements H315-H319-H335 Precautionary Statements P261-P305 + P351 + P338 Hazard Codes Xi Safety Phrases 26 RIDADR NONH for all modes of transport HS Code 2934999090 Synthetic Route 4-ethoxy-1-(2-m... 115494-62-7 2'-C-Methyl... 20724-73-6 Literature: Matsuda; Itoh; Takenuki; Sasaki; Ueda Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 3 p. 945 - 953 4-ethoxy-1-[2-C... 115494-61-6 2'-C-Methyl... 20724-73-6 Literature: Chemical and Pharmaceutical Bulletin, , vol. 35, # 9 p. 3967 - 3970 4-ethoxy-1-[3,5... 113648-22-9 2'-C-Methyl... 20724-73-6 Literature: Chemical and Pharmaceutical Bulletin, , vol. 35, # 9 p. 3967 - 3970 Precursor & DownStream Precursor 9 CAS#:115494-62-7 4-ethoxy-1-(2-m... CAS#:115494-61-6 4-ethoxy-1-[2-C... CAS#:113648-22-9 4-ethoxy-1-[3,5... CAS#:58-96-8 DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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