CAS Number19902-91-1
Synonyms(6S)-6-[2-(1,3-Benzodioxol-5-yl)ethyl]-5,6-dihydro-4-methoxy-2H-pyran-2-one Dihydromethysticin; (6S)-6-[2-(1,3-Benzodioxol-5-yl)ethyl]-4-methoxy-5,6-dihydro-2H-pyran-2-one; DIHYDROMETHYSTICIN
Molecular FormulaC15H16O5
Molecular Weight276.28
Purity≥95.0 (HPLC)%
Density1.3±0.1 g/cm3
Boiling Point476.1±45.0 °C at 760 mmHg
Symbol
Signal WordWarning
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| Chemical & Physical Properties | |
|---|---|
| CAS Number | 19902-91-1 |
| Catalog No. | 2A-9038259 |
| Chinese Name | 二氢麻醉椒苦素 |
| Synonyms | (6S)-6-[2-(1,3-Benzodioxol-5-yl)ethyl]-5,6-dihydro-4-methoxy-2H-pyran-2-one Dihydromethysticin; (6S)-6-[2-(1,3-Benzodioxol-5-yl)ethyl]-4-methoxy-5,6-dihydro-2H-pyran-2-one; DIHYDROMETHYSTICIN |
| Molecular Formula | C15H16O5 |
| Molecular Weight | 276.28 |
| Purity | ≥95.0 (HPLC) |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 476.1±45.0 °C at 760 mmHg |
| Storage Condition | 2-8°C |
| Application | Dihydromethysticin kavalactone has the activity of inducing CYP3A23. |
| MDL Number | MFCD00221731 |
| SMILES | COC1=CC(=O)O[C@@H](CCc2ccc3OCOc3c2)C1 |
| InChI | 1S/C15H16O5/c1-17-12-7-11(20-15(16)8-12)4-2-10-3-5-13-14(6-10)19-9-18-13/h3,5-6,8,11H,2,4,7,9H2,1H3/t11-/m0/s1 |
| InChI Key | RSIWXFIBHXYNFM-NSHDSACASA-N |
| Beilstein/REAXYS | 91699 |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | transportation |
| MSDS | msds/38259_1_19902_91_1.pdf |
| Bioactivity | Dihydromethysticin is one of the six major kavalactones found in the kava plant; has marked activity on the induction of CYP3A23. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Natural Products >> Others Research Areas >> Others References [1]. Ma Y, et al. Desmethoxyyangonin and dihydromethysticin are two major pharmacological kavalactones with marked activity on the induction of CYP3A23. Drug Metab Dispos. 2004 Nov;32(11):1317-24. [2]. Walden J, et al. Effects of kawain and dihydromethysticin on field potential changes in the hippocampus. Prog Neuropsychopharmacol Biol Psychiatry. 1997 May;21(4):697-706. [3]. Sarris J, et al. Kava: a comprehensive review of efficacy, safety, and psychopharmacology. Aust N Z J Psychiatry. 2011 Jan;45(1):27-35. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 476.1±45.0 °C at 760 mmHg Molecular Formula C15H16O5 Molecular Weight 276.284 Flash Point 214.1±28.8 °C Exact Mass 276.099762 PSA 53.99000 LogP 1.81 Vapour Pressure 0.0±1.2 mmHg at 25°C Index of Refraction 1.576 InChIKey RSIWXFIBHXYNFM-NSHDSACASA-N SMILES COC1=CC(=O)OC(CCc2ccc3c(c2)OCO3)C1 Storage condition 2-8°C |
| Use of | Dihydromethysticin is one of the six major kavalactones found in the kava plant; has marked activity on the induction of CYP3A23. Properties Name (+)-Dihydromethysticin Synonym More Synonyms Dihydromethysticin Biological Activity Description Dihydromethysticin is one of the six major kavalactones found in the kava plant; has marked activity on the induction of CYP3A23. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Natural Products >> Others Research Areas >> Others References [1]. Ma Y, et al. Desmethoxyyangonin and dihydromethysticin are two major pharmacological kavalactones with marked activity on the induction of CYP3A23. Drug Metab Dispos. 2004 Nov;32(11):1317-24. [2]. Walden J, et al. Effects of kawain and dihydromethysticin on field potential changes in the hippocampus. Prog Neuropsychopharmacol Biol Psychiatry. 1997 May;21(4):697-706. [3]. Sarris J, et al. Kava: a comprehensive review of efficacy, safety, and psychopharmacology. Aust N Z J Psychiatry. 2011 Jan;45(1):27-35. Chemical & Physical Properties Molecular Formula C15H16O5 Exact Mass 276.099762 PSA 53.99000 Index of Refraction 1.576 InChIKey RSIWXFIBHXYNFM-NSHDSACASA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip. |
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