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Home > Products > Pharmaceutical R&D Materials > Functional Building Blocks > 3,4-Dihydro-6-trifluoromethyl-2H-1,2,4-benzothiadiazine-7-sulphonamide-1,1-dioxide
3,4-Dihydro-6-trifluoromethyl-2H-1,2,4-benzothiadiazine-7-sulphonamide-1,1-dioxide structure, CAS 135-09-1

3,4-Dihydro-6-trifluoromethyl-2H-1,2,4-benzothiadiazine-7-sulphonamide-1,1-dioxide

CAS Number135-09-1

SynonymsEINECS 205-173-8; Robezon; Spandiuril; Saluron; MFCD00057316; hydroflumethyazide; Glomerulin; hydroflumenthiazide; Diurometon; hydroflumethiazide; Flutizide; Hidroflumetiazid; Diuredemina; Hidroalogen

Molecular FormulaC8H8F3N3O4S2

Molecular Weight331.29

Purity97%

Density1.678g/cm3

Boiling Point531.6ºC at 760 mmHg

Melting Point272-273ºC

Flash Point

Appearance

EINECS205-173-8

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Cat. No.: 2A-9003787 Purity: 97%
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Quality Control of [ 135-09-1 ] Purity: 97% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number135-09-1
Catalog No.2A-9003787
Chinese Name氢氟噻嗪
SynonymsEINECS 205-173-8; Robezon; Spandiuril; Saluron; MFCD00057316; hydroflumethyazide; Glomerulin; hydroflumenthiazide; Diurometon; hydroflumethiazide; Flutizide; Hidroflumetiazid; Diuredemina; Hidroalogen
Molecular FormulaC8H8F3N3O4S2
Molecular Weight331.29
Purity97
Density1.678g/cm3
Boiling Point531.6ºC at 760 mmHg
Melting Point272-273ºC
Storage ConditionRefrigerator
ApplicationHydroflumethiazide is an orally available thiazide diuretic. HFC has the ability to directly stimulate cell secretion in normal and alloxan-diabetic pancreas [1][2][3].
EINECS205-173-8
HTC2935009090
PubChem ID329750104
MDL NumberMFCD00057316
SMILESO=S1(C2=CC(S(=O)(N)=O)=C(C(F)(F)F)C=C2NCN1)=O
InChI1S/C8H8F3N3O4S2/c9-8(10,11)4-1-5-7(2-6(4)19(12,15)16)20(17,18)14-3-13-5/h1-2,13-14H,3H2,(H2,12,15,16)
InChI KeyDMDGGSIALPNSEE-UHFFFAOYSA-N
NACRES CodeNA.24
UNSPSC41116107
Hazard SymbolsTransport
Risk CodesR42/43
Safety DescriptionS36
MSDSmsds/3787_1_135_09_1.pdf
BioactivityHydroflumethiazide (Methforylthiazidine) is an orally active and potent thiazide diuretic. Hydroflumethiazide possesses the ability to directly stimulate A cell secretion in the normal and alloxan diabetic pancreas[1][2][3]. Related Catalog Research Areas >> Endocrinology Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease References [1]. Selvaag E, et al. Phototoxicity to sulphonamide derived oral antidiabetics and diuretics. Comparative in vitro and in vivo investigations. In Vivo. 1997 Jan-Feb;11(1):103-7. [2]. Brørs O, et al. Pharmacokinetics of a single oral dose of hydroflumethiazide in health and in cardiac failure.-. Eur J Clin Pharmacol. 1978 Nov 9;14(1):29-37. [3]. Hermansen K, et al. Effects of a thiazide diuretic (hydroflumethiazide) and a loop diuretic (bumetanide) on the endocrine pancreas: studies in vitro. Metabolism. 1985 Aug;34(8):784-9. Chemical & Physical Properties Density 1.678g/cm3 Boiling Point 531.6ºC at 760 mmHg Melting Point 272-273ºC Molecular Formula C8H8F3N3O4S2 Molecular Weight 331.29200 Flash Point 275.3ºC Exact Mass 330.99100 PSA 135.12000 LogP 3.34280 Vapour Pressure 2.2E-11mmHg at 25°C Index of Refraction 1.55 InChIKey DMDGGSIALPNSEE-UHFFFAOYSA-N SMILES NS(=O)(=O)c1cc2c(cc1C(F)(F)F)NCNS2(=O)=O Storage condition Refrigerator
Use ofHydroflumethiazide (Methforylthiazidine) is an orally active and potent thiazide diuretic. Hydroflumethiazide possesses the ability to directly stimulate A cell secretion in the normal and alloxan diabetic pancreas[1][2][3]. Properties Articles25 Name 1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1λ6,2,4-benzothiadiazine-7-sulfonamide Synonym More Synonyms hydroflumethiazide Biological Activity Description Hydroflumethiazide (Methforylthiazidine) is an orally active and potent thiazide diuretic. Hydroflumethiazide possesses the ability to directly stimulate A cell secretion in the normal and alloxan diabetic pancreas[1][2][3]. Related Catalog Research Areas >> Endocrinology Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease References [1]. Selvaag E, et al. Phototoxicity to sulphonamide derived oral antidiabetics and diuretics. Comparative in vitro and in vivo investigations. In Vivo. 1997 Jan-Feb;11(1):103-7. [2]. Brørs O, et al. Pharmacokinetics of a single oral dose of hydroflumethiazide in health and in cardiac failure.-. Eur J Clin Pharmacol. 1978 Nov 9;14(1):29-37. [3]. Hermansen K, et al. Effects of a thiazide diuretic (hydroflumethiazide) and a loop diuretic (bumetanide) on the endocrine pancreas: studies in vitro. Metabolism. 1985 Aug;34(8):784-9. Chemical & Physical Properties Molecular Formula C8H8F3N3O4S2 Exact Mass 330.99100 PSA 135.12000 LogP 3.34280 Index of Refraction 1.55 InChIKey DMDGGSIALPNSEE-UHFFFAOYSA-N Storage condition Refrigerator
Tax Rebate9.0%
SupervisionNone MFN tariff: 6.5% Ordinary tariff: 35.0%
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available
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