CAS Number15500-66-0
SynonymsEINECS 239-532-5; MFCD00079223; Pancuronium dibromide; Pancuronium Bromide
Molecular FormulaC35H60Br2N2O4
Molecular Weight732.67
Purity99.00%
Melting Point214 - 217ºC
AppearanceWhite to almost white crystalline powder, odorless
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 15500-66-0 |
| Catalog No. | 2A-9036566 |
| Chinese Name | 泮库溴铵 |
| Synonyms | EINECS 239-532-5; MFCD00079223; Pancuronium dibromide; Pancuronium Bromide |
| Molecular Formula | C35H60Br2N2O4 |
| Molecular Weight | 732.67 |
| Purity | 99.00 |
| Melting Point | 214 - 217ºC |
| Appearance | White to almost white crystalline powder, odorless |
| Storage Condition | Desiccate at RT |
| Packaging | III |
| Application | Pancuronium Dibromide is a competitive AChR antagonist with an IC50 of 5.5 nM. |
| PubChem ID | 7847558 |
| SMILES | CC(=O)OC1CC2CCC3C(CCC4(C)C3CC([N+]3(C)CCCCC3)C4OC(C)=O)C2(C)CC1[N+]1(C)CCCCC1.[Br-] |
| InChI | InChI=1S/C35H60N2O4.2BrH/c1-24(38)40-32-21-26-13-14-27-28(35(26,4)23-31(32)37(6)19-11-8-12-20-37)15-16-34(3)29(27)22-30(33(34)41-25(2)39)36(5)17-9-7-10-18-36;;/h26-33H,7-23H2,1-6H3;2*1H/q+2;;/p-2/t26-,27+,28-,29-,30-,31-,32-,33-,34-,35-;;/m0../s1 |
| InChI Key | FUSSNJWODJHPKO-MHLFSCIFSA-M |
| Hazard Symbols | 6.1(b) |
| Bioactivity | Chemical & Physical Properties |
| Use of | Pancuronium Dibromide is a bis-quaternary steroid that is a competitive nicotinic antagonist.Target: nAChRPancuronium dibromide is a competitive AChR antagonist (IC50 = 5.5 nM) and acts as a skeletal muscle relaxant. Pancuronium dibromide interrupts neuromuscular transmission by competing with acetylcholine for receptor sites on the motor end-plate. Pancuronium dibromide is a non-depolarizing agent. Pancuronium is a typical non-depolarizing curare-mimetic muscle relaxant. It acts as a competitive acetylcholine antagonist on neuromuscular junctions, displacing acetylcholine (hence competitive) from its post-synaptic nicotinic acetylcholine receptors. It is (unlike suxamethonium) a non-depolarizing agent, which means that it causes no spontaneous depolarizations upon association with the nicotinic receptor in neuromuscular junction, thus producing no muscle fasciculations upon administration [1-3]. Properties Articles38 Biological Activity Chemical & Physical Properties |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 United Nations shipping name European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (Pancuronium bromide) IMDG Code: TOXIC SOLID, ORGANIC, N.O.S. (Pancuronium bromide) International air transport hazard regulations: Toxic solid, organic, n.o.s. (Pancuronium bromide) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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