CAS Number13063-04-2
Synonyms2,3-Dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridinium chloride; [1,3]Benzodioxolo[5,6-c]phenanthridinium, 2,3-dimethoxy-12-methyl-, chloride (1:1); 2,3-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium chloride; Nitidine chloride; 2,3-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium,chloride
Molecular FormulaC21H18ClNO4
Molecular Weight383.825
Purity98.00%
Density1.35g/cm3
Boiling Point619ºC at 760 mmHg
Melting Point281-282ºC
Appearancewhite to beige
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 13063-04-2 |
| Catalog No. | 2A-9035318 |
| Chinese Name | 氯化两面针碱 |
| Synonyms | 2,3-Dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridinium chloride; [1,3]Benzodioxolo[5,6-c]phenanthridinium, 2,3-dimethoxy-12-methyl-, chloride (1:1); 2,3-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium chloride; Nitidine chloride; 2,3-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium,chloride |
| Molecular Formula | C21H18ClNO4 |
| Molecular Weight | 383.825 |
| Purity | 98.00 |
| Density | 1.35g/cm3 |
| Boiling Point | 619ºC at 760 mmHg |
| Melting Point | 281-282ºC |
| Appearance | white to beige |
| Water Solubility | DMSO: soluble1mg/mL, clear (warmed) |
| Storage Condition | ?20°C |
| Application | Nitidine chloride is a compound with antimalarial activity isolated from Zanthoxylum nitidum (Roxb) DC. Nitidine chloride exerts anti-cancer activity through multiple target pathways, such as inducing |
| HTC | 2933990090 |
| PubChem ID | 559845 |
| SMILES | COc1cc2c[n+](C)c3c4cc5c(cc4ccc3c2cc1OC)OCO5.[Cl-] |
| InChI | InChI=1S/C21H18NO4.ClH/c1-22-10-13-7-17(23-2)18(24-3)8-15(13)14-5-4-12-6-19-20(26-11-25-19)9-16(12)21(14)22;/h4-10H,11H2,1-3H3;1H/q+1;/p-1 |
| InChI Key | QLDAACVSUMUMOR-UHFFFAOYSA-M |
| Hazard Symbols | transportation |
| Bioactivity | Chemical & Physical Properties |
| Use of | Nitidine chloride, a potential anti-malarial lead compound derived from Zanthoxylum nitidum (Roxb) DC, exerts potent anticancer activity through diverse pathways, including inducing apoptosis, inhibiting STAT3 signaling cascade, DNA topoisomerase 1 and 2A, ERK and c-Src/FAK associated signaling pathway. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kB pathway[1][2][3][4][5][6]. Properties Articles23 Biological Activity Chemical & Physical Properties |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip. |
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