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2-Oxindole structure, CAS 59-48-3

2-Oxindole

CAS Number59-48-3

SynonymsOxindole; 3H-Indol-2-ol; 2-INDOLINONE; 2-indolinon; 2-Oxindoline; 2-oxo-indoline; EINECS 200-429-5; OXINDOL; indolinone; 1,3-Dihydro-2H-indol-2-one; 2-Indolone; Indolin-2-one; 2-Oxiindole; MFCD00005711; 2-Oxindole; 1,3-dihydro-indol-2-one

Molecular FormulaC8H7NO

Molecular Weight133.147

Purity98%

Density1.3±0.1 g/cm3

Boiling Point312.8±45.0 °C at 760 mmHg

Melting Point123-128 °C(lit.)

Flash Point

AppearanceOff-white crystalline powder

EINECS200-429-5

MSDSChineseEnglish

Symbol6.1(b)

Signal WordWarning

Cat. No.: 2A-9003482 Purity: 98%
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Quality Control of [ 59-48-3 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number59-48-3
Catalog No.2A-9003482
Chinese Name2-吲哚酮
SynonymsOxindole; 3H-Indol-2-ol; 2-INDOLINONE; 2-indolinon; 2-Oxindoline; 2-oxo-indoline; EINECS 200-429-5; OXINDOL; indolinone; 1,3-Dihydro-2H-indol-2-one; 2-Indolone; Indolin-2-one; 2-Oxiindole; MFCD00005711; 2-Oxindole; 1,3-dihydro-indol-2-one
Molecular FormulaC8H7NO
Molecular Weight133.147
Purity98
Density1.3±0.1 g/cm3
Boiling Point312.8±45.0 °C at 760 mmHg
Melting Point123-128 °C(lit.)
AppearanceOff-white crystalline powder
Water Solubilityinsoluble
Storage ConditionThis product should be sealed and stored at 4℃.
PackagingIII
ApplicationOxindole (Indolin-2-one) is an aromatic heterocyclic building block. Oxindole derivatives have become major compounds in kinase inhibitor research.
EINECS200-429-5
HTC29337900
SMILESO=C1Cc2ccccc2N1
InChIInChI=1S/C8H7NO/c10-8-5-6-3-1-2-4-7(6)9-8/h1-5,9-10H
InChI KeyJYGFTBXVXVMTGB-UHFFFAOYSA-N
Hazard Symbols6.1(b)
Risk CodesR22
MSDSmsds/3482_1_59_48_3.pdf
BioactivityOxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors. Related Catalog Signaling Pathways >> Others >> Others Natural Products >> Alkaloid Research Areas >> Cancer Research Areas >> Metabolic Disease Research Areas >> Endocrinology Research Areas >> Inflammation/Immunology Research Areas >> Infection Research Areas >> Neurological Disease In Vitro Oxindole (Indolin-2-one) is a bicyclic structure consisting of a benzene ring fused to 2-pyrrolidone. Substituted indolinones can be referred as 'privileged structures' owing to their excellent binding affinity for many receptors and to the number of approved drugs containing this scaffold[1]. Oxindole has been found in tissues and fluids of mammals as well as natural products produced by a range of plants, bacteria and invertebrates. 2-indolinone derivatives possess diverse range of pharmacological activities including anti-cancer, anti-HIV, anti-diabetic, antibacterial, antioxidant, kinase inhibitory, AChE inhibitory, anti-leishmanial, b3 adrenergic receptor agonistic, phosphatase inhibitory, analgesic, spermicidal, vasopressin antagonists, progesterone antagonists, neuroprotection, NMDA blocker and sleep inducing activities[2]. References [1]. Leoni A, et al. 2-Indolinone a versatile scaffold for treatment of cancer: a patent review (2008-2014). Expert Opin Ther Pat. 2016;26(2):149-73. [2]. Kaur M, et al. Oxindole: A chemical prism carrying plethora of therapeutic benefits. Eur J Med Chem. 2016 Nov 10;123:858-894. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 312.8±45.0 °C at 760 mmHg Melting Point 123-128 °C(lit.) Molecular Formula C8H7NO Molecular Weight 133.147 Flash Point 190.0±18.0 °C Exact Mass 133.052765 PSA 29.10000 LogP 0.61 Vapour Pressure 0.0±0.7 mmHg at 25°C Index of Refraction 1.640 InChIKey JYGFTBXVXVMTGB-UHFFFAOYSA-N SMILES O=C1Cc2ccccc2N1 Storage condition Refrigerator Water Solubility insoluble
Use ofOxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors. Properties Articles31 Name indolin-2-one Synonym More Synonyms Oxindole Biological Activity Description Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors. Related Catalog Signaling Pathways >> Others >> Others Natural Products >> Alkaloid Research Areas >> Cancer Research Areas >> Metabolic Disease Research Areas >> Endocrinology Research Areas >> Inflammation/Immunology Research Areas >> Infection Research Areas >> Neurological Disease References [1]. Leoni A, et al. 2-Indolinone a versatile scaffold for treatment of cancer: a patent review (2008-2014). Expert Opin Ther Pat. 2016;26(2):149-73. [2]. Kaur M, et al. Oxindole: A chemical prism carrying plethora of therapeutic benefits. Eur J Med Chem. 2016 Nov 10;123:858-894. Chemical & Physical Properties Molecular Formula C8H7NO Exact Mass 133.052765 PSA 29.10000 Index of Refraction 1.640 InChIKey JYGFTBXVXVMTGB-UHFFFAOYSA-N Storage condition Refrigerator Water Solubility insoluble
Tax Rebate9.0%
SupervisionNone MFN tariff: 9.0% Ordinary tariff: 20.0%
Transport InfoProduct name: Purity: 0.0%
MSDS Transport InfoModule 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified Oxindole Modification Number: 5
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