CAS Number10347-81-6
SynonymsDeprilept; 9,10-Ethanoanthracene-9(10H)-propanamine, N-methyl-, hydrochloride (1:1); Maprotiline hydrochloride; 9-(g-Methylaminopropyl)-9,10-dihydro-9,10-ethanoanthracene Hydrochloride; N-Methyl-3-tetracyclo[6.6.2.0.0]hexadeca-2,4,6,9,11,13-hexaen-1-ylpropan-1-aminhydrochlorid; EINECS 233-758-8; 3-(9,10-ethanoanthracen-9(10H)-yl)-N-methylpropan-1-amine hydrochloride (1:1); MFCD00079464; N-methyl-3-tetracyclo[6.6.2.0.0]hexadeca-2,4,6,9,11,13-hexaen-1-ylpropan-1-amine hydrochloride; N-méthyl-3-tétracyclo[6.6.2.0.0]hexadéca-2,4,6,9,11,13-hexaén-1-ylpropan-1-amine chlorhydrate; Psymion; 9-(γ-Methylaminopropyl)-9,10-dihydro-9,10-ethanoanthracene Hydrochloride
Molecular FormulaC20H24ClN
Molecular Weight313.86
Purity98.00%
Boiling Point399.6ºC at 760 mmHg
Melting Point230-232ºC
Appearanceliquid
EINECS200-659-6
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 10347-81-6 |
| Catalog No. | 2A-9034810 |
| Chinese Name | 马替普林盐酸盐 |
| Synonyms | Deprilept; 9,10-Ethanoanthracene-9(10H)-propanamine, N-methyl-, hydrochloride (1:1); Maprotiline hydrochloride; 9-(g-Methylaminopropyl)-9,10-dihydro-9,10-ethanoanthracene Hydrochloride; N-Methyl-3-tetracyclo[6.6.2.0.0]hexadeca-2,4,6,9,11,13-hexaen-1-ylpropan-1-aminhydrochlorid; EINECS 233-758-8; 3-(9,10-ethanoanthracen-9(10H)-yl)-N-methylpropan-1-amine hydrochloride (1:1); MFCD00079464; N-methyl-3-tetracyclo[6.6.2.0.0]hexadeca-2,4,6,9,11,13-hexaen-1-ylpropan-1-amine hydrochloride; N-méthyl-3-tétracyclo[6.6.2.0.0]hexadéca-2,4,6,9,11,13-hexaén-1-ylpropan-1-amine chlorhydrate; Psymion; 9-(γ-Methylaminopropyl)-9,10-dihydro-9,10-ethanoanthracene Hydrochloride |
| Molecular Formula | C20H24ClN |
| Molecular Weight | 313.86 |
| Purity | 98.00 |
| Boiling Point | 399.6ºC at 760 mmHg |
| Melting Point | 230-232ºC |
| Appearance | liquid |
| Water Solubility | H2O: 50 mg/mL | Soluble to 50mg/ml in water. Solub |
| Storage Condition | Seal in a cool, dry place. |
| Packaging | III |
| Application | Maprotiline hydrochloride is a norepinephrine reuptake inhibitor and is a tetracyclic antidepressant compound (TeCA). |
| EINECS | 200-659-6 |
| HTC | 2921499090 |
| PubChem ID | 855591 |
| SMILES | Cl.CNCCCC12CCC(c3ccccc13)c4ccccc24 |
| InChI | 1S/C20H23N.ClH/c1-21-14-6-12-20-13-11-15(16-7-2-4-9-18(16)20)17-8-3-5-10-19(17)20;/h2-5,7-10,15,21H,6,11-14H2,1H3;1H |
| InChI Key | NZDMFGKECODQRY-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | 6.1(b) |
| MSDS | msds/34810_1_10347_81_6.pdf |
| Bioactivity | Maprotiline HCl is a selective noradrenalin re-uptake inhibitor and a tetracyclic antidepressant.Target: OthersMaprotiline (sold as Deprilept, Ludiomil, Psymion) is a tetracyclic antidepressant (TeCA). However, Maprotiline's fourth ring is spurious, as formed by a bridge across the central tricyclic ring. It is a strong norepinephrine reuptake inhibitor with only weak effects on serotonin and dopamine reuptake. It exerts strong blocking effect at H1 receptors, moderate at 5-HT2 and alpha1 and weak blocking effect at D2 and mACh postsynaptic receptors [1, 2]. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Neurological Disease References [1]. Peng, W.H., et al., Berberine produces antidepressant-like effects in the forced swim test and in the tail suspension test in mice. Life Sci, 2007. 81(11): p. 933-8. [2]. http://en.wikipedia.org/wiki/Maprotiline Chemical & Physical Properties Boiling Point 399.6ºC at 760 mmHg Melting Point 230-232ºC Molecular Formula C20H24ClN Molecular Weight 313.864 Flash Point 187.7ºC Exact Mass 313.159729 PSA 12.03000 LogP 5.40430 Vapour Pressure 9.8E-08mmHg at 25°C InChIKey NZDMFGKECODQRY-UHFFFAOYSA-N SMILES CNCCCC12CCC(c3ccccc31)c1ccccc12.Cl Storage condition Store at RT Water Solubility H2O: 50 mg/mL | Soluble to 50mg/ml in water. Soluble in ethanol at 10mM |
| Use of | Maprotiline HCl is a selective noradrenalin re-uptake inhibitor and a tetracyclic antidepressant.Target: OthersMaprotiline (sold as Deprilept, Ludiomil, Psymion) is a tetracyclic antidepressant (TeCA). However, Maprotiline's fourth ring is spurious, as formed by a bridge across the central tricyclic ring. It is a strong norepinephrine reuptake inhibitor with only weak effects on serotonin and dopamine reuptake. It exerts strong blocking effect at H1 receptors, moderate at 5-HT2 and alpha1 and weak blocking effect at D2 and mACh postsynaptic receptors [1, 2]. Properties Articles29 Name Maprotiline Hydrochloride Synonym More Synonyms Maprotiline Hydrochloride Biological Activity Description Maprotiline HCl is a selective noradrenalin re-uptake inhibitor and a tetracyclic antidepressant.Target: OthersMaprotiline (sold as Deprilept, Ludiomil, Psymion) is a tetracyclic antidepressant (TeCA). However, Maprotiline's fourth ring is spurious, as formed by a bridge across the central tricyclic ring. It is a strong norepinephrine reuptake inhibitor with only weak effects on serotonin and dopamine reuptake. It exerts strong blocking effect at H1 receptors, moderate at 5-HT2 and alpha1 and weak blocking effect at D2 and mACh postsynaptic receptors [1, 2]. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Neurological Disease References [1]. Peng, W.H., et al., Berberine produces antidepressant-like effects in the forced swim test and in the tail suspension test in mice. Life Sci, 2007. 81(11): p. 933-8. [2]. http://en.wikipedia.org/wiki/Maprotiline Chemical & Physical Properties Exact Mass 313.159729 PSA 12.03000 LogP 5.40430 InChIKey NZDMFGKECODQRY-UHFFFAOYSA-N Storage condition Store at RT |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 99.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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