CAS Number274901-16-5
SynonymsGalvus; (-)-(2S)-1-[[(3-Hydroxytricyclo[3.3.1.1[3,7]]dec-1-yl)amino]acetyl]pyrrolidine-2-carbonitrile; Vildagliptin; Laf 237; (2S)-1-[N-(3-Hydroxyadamantan-1-yl)glycyl]pyrrolidine-2-carbonitrile; (2S)-1-[N-(3-hydroxytricyclo[3.3.1.1]dec-1-yl)glycyl]pyrrolidine-2-carbonitrile; Unii-I6B4B2U96p; (2S)-1-[N-(3-Hydroxyadamantan-1-yl)glycyl]-2-pyrrolidinecarbonitrile
Molecular FormulaC17H25N3O2
Molecular Weight303.40
Purity≥98 (HPLC)%
Density1.27 g/cm3
Boiling Point531.3ºC at 760 mmHg
Melting Point153-155?C
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 274901-16-5 |
| Catalog No. | 2A-9034769 |
| Chinese Name | 维达列汀 |
| Synonyms | Galvus; (-)-(2S)-1-[[(3-Hydroxytricyclo[3.3.1.1[3,7]]dec-1-yl)amino]acetyl]pyrrolidine-2-carbonitrile; Vildagliptin; Laf 237; (2S)-1-[N-(3-Hydroxyadamantan-1-yl)glycyl]pyrrolidine-2-carbonitrile; (2S)-1-[N-(3-hydroxytricyclo[3.3.1.1]dec-1-yl)glycyl]pyrrolidine-2-carbonitrile; Unii-I6B4B2U96p; (2S)-1-[N-(3-Hydroxyadamantan-1-yl)glycyl]-2-pyrrolidinecarbonitrile |
| Molecular Formula | C17H25N3O2 |
| Molecular Weight | 303.40 |
| Purity | ≥98 (HPLC) |
| Density | 1.27 g/cm3 |
| Boiling Point | 531.3ºC at 760 mmHg |
| Melting Point | 153-155?C |
| Appearance | powder |
| Storage Condition | -20°C Freezer |
| Application | Vildagliptin (LAF-237; NVP-LAF 237) inhibits DPP-4 with an IC50 of 2.3 nM. |
| HTC | 2933990090 |
| PubChem ID | 12015446 |
| MDL Number | MFCD08275142 |
| SMILES | N#C[C@H]1N(CCC1)C(CN[C@@](C[C@]2([H])C3)(C[C@@](C2)([H])C4)C[C@@]34O)=O |
| InChI | 1S/C17H25N3O2/c18-9-14-2-1-3-20(14)15(21)10-19-16-5-12-4-13(6-16)8-17(22,7-12)11-16/h12-14,19,22H,1-8,10-11H2/t12-,13+,14-,16+,17-/m0/s1 |
| InChI Key | SYOKIDBDQMKNDQ-NHMCJKAESA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Use of | Properties Name Vildagliptin Synonym More Synonyms Vildagliptin (LAF-237) Biological Activity Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Dipeptidyl Peptidase Research Areas >> Metabolic Disease References [1]. Villhauer EB, Brinkman JA, Naderi GB et al. 1-[[(3-hydroxy-1-adamantyl) amino]acetyl]-2-cyano-(S)-pyrrolidine: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties. J Med Chem 2003;46:2774-89. [2]. He YL, Kulmatycki K, Zhang Y, Pharmacokinetics of vildagliptin in patients with varying degrees of renal impairment. Int J Clin Pharmacol Ther. 2013 Jun 19. [3]. Avila Dde L, Araújo GR, Silva M, Vildagliptin ameliorates oxidative stress and pancreatic beta cell destruction in type 1 diabetic rats. Arch Med Res. 2013 Apr;44(3):194-202. Chemical & Physical Properties Molecular Formula C17H25N3O2 Exact Mass 303.19500 PSA 76.36000 LogP 1.50308 InChIKey SYOKIDBDQMKNDQ-XWTIBIIYSA-N Safety Information Hazard Codes Xi HS Code 2933990090 Synthetic Route 3-Amino-1-hydro... (2S)-1-(Chloroa... 207557-35-5 Vildagliptin (L... 274901-16-5 Literature: Letters in Organic Chemistry, , vol. 10, # 3 p. 159 - 163 3-Amino-1-hydro... Vildagliptin (L... 274901-16-5 N-acetic acid-1... 1032564-18-3 (S)-pyrrolidine... 204387-53-1 Vildagliptin (L... 274901-16-5 Precursor & DownStream Precursor 10 CAS#:702-82-9 3-Amino-1-hydro... CAS#:207557-35-5 (2S)-1-(Chloroa... CAS#:1032564-18-3 N-acetic acid-1... CAS#:204387-53-1 (S)-pyrrolidine... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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