CAS Number10083-24-6
Synonyms3,3',4'5-Tetrahydroxystilbene; E-Piceatannol; 3,3′,4,5′-Tetrahydroxy-trans-stilbene; 3,3',4,5'-Tetrahydroxy-trans-stilbene; 3,4,3',5'-Tetrahydroxy-trans-stilbene; 4-[(E)-2-(3,5-Dihydroxyphenyl)vinyl]benzene-1,2-diol; 3,5,3',4'-tetrahydroxystilbene; 4-[(E)-2-(3,5-Dihydroxyphenyl)vinyl]-1,2-benzenediol; Piceatannol; 4-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,2-diol; MFCD00221715; 4-(2-(3,5-Dihydroxyphenyl)vinyl)-1,2-benzenediol; (E)-4-[2-(3,5Dihydroxyphenyl)ethenyl]1,2-benzenediol; (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol; 5-[(E)-2-(3,4-Dihydroxyphenyl)vinyl]benzene-1,3-diol; trans-3,3',4,5'-tetrahydroxystilbene; 3,3',4,5'-tetrahydroxystilbene
Molecular FormulaC14H12O4
Molecular Weight244.24
Purity98.00%
Density1.5±0.1 g/cm3
Boiling Point507.3±38.0 °C at 760 mmHg
Melting Point223-227ºC
AppearanceLight brown to yellow powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 10083-24-6 |
| Catalog No. | 2A-9034625 |
| Chinese Name | 白皮杉醇； 比杉特醇 |
| Synonyms | 3,3',4'5-Tetrahydroxystilbene; E-Piceatannol; 3,3′,4,5′-Tetrahydroxy-trans-stilbene; 3,3',4,5'-Tetrahydroxy-trans-stilbene; 3,4,3',5'-Tetrahydroxy-trans-stilbene; 4-[(E)-2-(3,5-Dihydroxyphenyl)vinyl]benzene-1,2-diol; 3,5,3',4'-tetrahydroxystilbene; 4-[(E)-2-(3,5-Dihydroxyphenyl)vinyl]-1,2-benzenediol; Piceatannol; 4-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,2-diol; MFCD00221715; 4-(2-(3,5-Dihydroxyphenyl)vinyl)-1,2-benzenediol; (E)-4-[2-(3,5Dihydroxyphenyl)ethenyl]1,2-benzenediol; (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol; 5-[(E)-2-(3,4-Dihydroxyphenyl)vinyl]benzene-1,3-diol; trans-3,3',4,5'-tetrahydroxystilbene; 3,3',4,5'-tetrahydroxystilbene |
| Molecular Formula | C14H12O4 |
| Molecular Weight | 244.24 |
| Purity | 98.00 |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 507.3±38.0 °C at 760 mmHg |
| Melting Point | 223-227ºC |
| Appearance | Light brown to yellow powder |
| Water Solubility | H2O: 0.5 mg/mL |
| Storage Condition | 1. Storage Store at 2-8°. |
| Application | Piceatannol is a selective inhibitor of the protein tyrosine kinase Syk. It can inhibit ICa, L, Ito, IKr, Ca2+ transfer and Na+-Ca2+ exchange except IK1. |
| HTC | 2907299090 |
| PubChem ID | 8189 |
| SMILES | Oc1cc(O)cc(C=Cc2ccc(O)c(O)c2)c1 |
| InChI | InChI=1S/C14H12O4/c15-11-5-10(6-12(16)8-11)2-1-9-3-4-13(17)14(18)7-9/h1-8,15-18H/b2-1+ |
| InChI Key | CDRPUGZCRXZLFL-OWOJBTEDSA-N |
| Hazard Symbols | transportation |
| Bioactivity | Piceatannol is a selective inhibitor of protein tyrosine kinase Syk. It could inhibit ICa,L, Ito, IKr, Ca2+ transients and Na+-Ca2+ exchange except IK1. Shows multiple biological activities such as anti-inflammatory, antiproliferative and immunomodulatory effects.In vitro: The treatment of human myeloid cells with piceatannol suppressed TNF-induced DNA binding activity of NF-κB. The effect of piceatannol was not restricted to myeloid cells, as TNF-induced NF-κB activation was also suppressed in lymphocyte and epithelial cells. Piceatannol also inhibited NF-κB activated by H2O2, PMA, LPS, okadaic acid, and ceramide. [1] Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Syk Research Areas >> Cancer Natural Products >> Phenols References [1]. Kazuhiro Ashikawa et al. Piceatannol Inhibits TNF-Induced NF-κB Activation and NF-κB-Mediated Gene Expression Through Suppression of IκBα Kinase and p65 Phosphorylation. J Immunol, 2002 Dec 1, 169(11):6490-7. [2]. Wen-Pin Chen et al. Piceatannol, a derivative of resveratrol, moderately slows INa inactivation and exerts antiarrhythmic action in ischaemia-reperfused rat hearts. Br J Pharmacol.2009 Jun, 157(3), 381-391. Chemical & Physical Properties Density 1.5±0.1 g/cm3 Boiling Point 507.3±38.0 °C at 760 mmHg Melting Point 223-227ºC Molecular Formula C14H12O4 Molecular Weight 244.243 Flash Point 252.2±21.4 °C Exact Mass 244.073563 PSA 80.92000 LogP 2.69 Vapour Pressure 0.0±1.4 mmHg at 25°C Index of Refraction 1.801 InChIKey CDRPUGZCRXZLFL-OWOJBTEDSA-N SMILES Oc1cc(O)cc(C=Cc2ccc(O)c(O)c2)c1 Storage condition 2-8°C Water Solubility H2O: 0.5 mg/mL |
| Use of | Piceatannol is a selective inhibitor of protein tyrosine kinase Syk. It could inhibit ICa,L, Ito, IKr, Ca2+ transients and Na+-Ca2+ exchange except IK1. Shows multiple biological activities such as anti-inflammatory, antiproliferative and immunomodulatory effects.In vitro: The treatment of human myeloid cells with piceatannol suppressed TNF-induced DNA binding activity of NF-κB. The effect of piceatannol was not restricted to myeloid cells, as TNF-induced NF-κB activation was also suppressed in lymphocyte and epithelial cells. Piceatannol also inhibited NF-κB activated by H2O2, PMA, LPS, okadaic acid, and ceramide. [1] Properties Articles92 Name Piceatannol Synonym More Synonyms Piceatannol Biological Activity Description Piceatannol is a selective inhibitor of protein tyrosine kinase Syk. It could inhibit ICa,L, Ito, IKr, Ca2+ transients and Na+-Ca2+ exchange except IK1. Shows multiple biological activities such as anti-inflammatory, antiproliferative and immunomodulatory effects.In vitro: The treatment of human myeloid cells with piceatannol suppressed TNF-induced DNA binding activity of NF-κB. The effect of piceatannol was not restricted to myeloid cells, as TNF-induced NF-κB activation was also suppressed in lymphocyte and epithelial cells. Piceatannol also inhibited NF-κB activated by H2O2, PMA, LPS, okadaic acid, and ceramide. [1] Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Syk Research Areas >> Cancer Natural Products >> Phenols References [1]. Kazuhiro Ashikawa et al. Piceatannol Inhibits TNF-Induced NF-κB Activation and NF-κB-Mediated Gene Expression Through Suppression of IκBα Kinase and p65 Phosphorylation. J Immunol, 2002 Dec 1, 169(11):6490-7. [2]. Wen-Pin Chen et al. Piceatannol, a derivative of resveratrol, moderately slows INa inactivation and exerts antiarrhythmic action in ischaemia-reperfused rat hearts. Br J Pharmacol.2009 Jun, 157(3), 381-391. Chemical & Physical Properties Molecular Formula C14H12O4 Exact Mass 244.073563 PSA 80.92000 Index of Refraction 1.801 InChIKey CDRPUGZCRXZLFL-OWOJBTEDSA-N |
| Tax Rebate | 9.0% |
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| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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