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Tween 20 structure, CAS 9005-64-5

Tween 20

CAS Number9005-64-5

SynonymsPolysorbate 40 (NF); Polyoxyethylene (20) sorbitan monolaurate; polyoxyethylene sorbitan monolaurate; Tween.(TM). 20; Polysorbate (INN); Tween 20; 2-[2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl dodecanoate; MDL 11,939; EINECS 500-018-3; Polysorbate 60 (NF); Polysorbate; Polysorbate 20 (NF); monododecanoate

Molecular FormulaC26H50O10

Molecular Weight604.813

Purity98.00%

Density1.1±0.1 g/cm3

Boiling Point695.8±55.0 °C at 760 mmHg

Melting Point

Flash Point

AppearanceLight yellow oily liquid

EINECS

MSDSChineseEnglish

Symboltransportation

Signal WordWarning

Cat. No.: 2A-9034444 Purity: 98.00%
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Quality Control of [ 9005-64-5 ] Purity: 98.00% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number9005-64-5
Catalog No.2A-9034444
Chinese Name吐温20
SynonymsPolysorbate 40 (NF); Polyoxyethylene (20) sorbitan monolaurate; polyoxyethylene sorbitan monolaurate; Tween.(TM). 20; Polysorbate (INN); Tween 20; 2-[2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl dodecanoate; MDL 11,939; EINECS 500-018-3; Polysorbate 60 (NF); Polysorbate; Polysorbate 20 (NF); monododecanoate
Molecular FormulaC26H50O10
Molecular Weight604.813
Purity98.00
Density1.1±0.1 g/cm3
Boiling Point695.8±55.0 °C at 760 mmHg
AppearanceLight yellow oily liquid
Water Solubility100 g/L | 100 g/L
Storage ConditionSealed and protected from light at room temperatur
ApplicationPolysorbate 20 is a polyoxyethylene (POE) type nonionic surfactant [1][2][3].
HTC34021300
SMILESCCCCCCCCCCCC(=O)OCCOCC(OCCO)C1OCC(OCCO)C1OCCO
InChIInChI=1S/C26H50O10/c1-2-3-4-5-6-7-8-9-10-11-24(30)34-19-18-31-20-22(32-15-12-27)26-25(35-17-14-29)23(21-36-26)33-16-13-28/h22-23,25-29H,2-21H2,1H3
InChI KeyHMFKFHLTUCJZJO-UHFFFAOYSA-N
Hazard Symbolstransportation
Safety DescriptionS24/25
BioactivityPolysorbate 20 is a polyoxyethylene (POE)-type nonionic surfactant[1][2][3]. Related Catalog Research Areas >> Others Signaling Pathways >> Others >> Others In Vitro Addition of Polysorbate 20 can modify lignin surface properties to change its hydrophobicity, hydrogen bonding ability and surface charges, thus reducing the non-productive adsorption of proteins[1]. Polysorbate 20 (0.35%-0.7% w/w) added to 0.05 mol/L of phosphate buffer pH 6.5 dramatically increased the apparent solubility of the drug from 0.8 μg/ml even to 353 μg/ml, while its effect in lower pH or in water was much smaller (20 μg/ml in pH 4.5). The increased concentration of phosphate salts (0.2 mol/l) at pH 6.5 in the presence of 0.7% of polysorbate 20, resulted in further increase of candesartan cilexetil solubility to 620 μg/ml[2]. References [1]. Yu-An Chen, et al. Evaluation of the action of Tween 20 non-ionic surfactant during enzymatic hydrolysis of lignocellulose: Pretreatment, hydrolysis conditions and lignin structure. Bioresour Technol. 2018 Dec;269:329-338. [2]. Katarzyna Hoppe, et al. The effect of polysorbate 20 on solubility and stability of candesartan cilexetil in dissolution media. AAPS PharmSciTech. 2014 Oct;15(5):1116-25. [3]. JustynaŁuczak, et al. Micelle formation of Tween 20 nonionic surfactant in imidazolium ionic liquids. Colloids and Surfaces A: Physicochemical and Engineering Aspects. Volume 471, 20 April 2015, Pages 26-37. Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 695.8±55.0 °C at 760 mmHg Molecular Formula C26H50O10 Molecular Weight 604.813 Flash Point 207.1±25.0 °C Exact Mass 604.418640 PSA 133.14000 LogP 5.37 Vapour Pressure 0.0±5.0 mmHg at 25°C Index of Refraction 1.502 InChIKey HMFKFHLTUCJZJO-UHFFFAOYSA-N SMILES CCCCCCCCCCCC(=O)OCCOCC(OCCO)C1OCC(OCCO)C1OCCO Storage condition 0-6°C Stability Stable. Incompatible with strong oxidizing agents. Water Solubility 100 g/L | 100 g/L
Use ofPolysorbate 20 is a polyoxyethylene (POE)-type nonionic surfactant[1][2][3]. Properties Articles108 Name polysorbate 20 Synonym More Synonyms Tween 20 Biological Activity Description Polysorbate 20 is a polyoxyethylene (POE)-type nonionic surfactant[1][2][3]. Related Catalog Research Areas >> Others Signaling Pathways >> Others >> Others References [2]. Katarzyna Hoppe, et al. The effect of polysorbate 20 on solubility and stability of candesartan cilexetil in dissolution media. AAPS PharmSciTech. 2014 Oct;15(5):1116-25. [3]. JustynaŁuczak, et al. Micelle formation of Tween 20 nonionic surfactant in imidazolium ionic liquids. Colloids and Surfaces A: Physicochemical and Engineering Aspects. Volume 471, 20 April 2015, Pages 26-37. Chemical & Physical Properties Molecular Formula C26H50O10 Exact Mass 604.418640 PSA 133.14000 Index of Refraction 1.502 InChIKey HMFKFHLTUCJZJO-UHFFFAOYSA-N SMILES CCCCCCCCCCCC(=O)OCCOCC(OCCO)C1OCC(OCCO)C1OCCO Stability Stable. Incompatible with strong oxidizing agents.
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available
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