CAS Number9004-99-3
SynonymsEthylene glycol, monostearate; Stearic acid, 2-hydroxyethyl ester; MFCD00151755; 2-Hydroxyethyl octadecanoate; 2-Hydroxyethyl stearate; ETHYLENE GLYCOL MONOSTEARATE; Octadecanoic acid, 2-hydroxyethyl ester; Poly(oxy-1,2-ethanediyl), .α.-hydro-.ω.-hydroxy-, octadecanoate; Polyoxyethylene stearate
Molecular FormulaC20H40O3
Molecular Weight328.530
Purity98.00%
Density0.9±0.1 g/cm3
Boiling Point438.4±18.0 °C at 760 mmHg
Melting Point47ºC
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 9004-99-3 |
| Catalog No. | 2A-9034436 |
| Chinese Name | 聚乙二醇硬脂酸酯 |
| Synonyms | Ethylene glycol, monostearate; Stearic acid, 2-hydroxyethyl ester; MFCD00151755; 2-Hydroxyethyl octadecanoate; 2-Hydroxyethyl stearate; ETHYLENE GLYCOL MONOSTEARATE; Octadecanoic acid, 2-hydroxyethyl ester; Poly(oxy-1,2-ethanediyl), .α.-hydro-.ω.-hydroxy-, octadecanoate; Polyoxyethylene stearate |
| Molecular Formula | C20H40O3 |
| Molecular Weight | 328.530 |
| Purity | 98.00 |
| Density | 0.9±0.1 g/cm3 |
| Boiling Point | 438.4±18.0 °C at 760 mmHg |
| Melting Point | 47ºC |
| Appearance | powder |
| Storage Condition | 1.50kg, 200kg iron drum or plastic drum. Store in |
| Application | Polyoxyethylene stearate (POES) is a nonionic emulsifier. |
| PubChem ID | 90558 |
| MDL Number | MFCD00148007 |
| SMILES | O(CCO)C(=O)CCCCCCCCCCCCCCCCC |
| InChI | 1S/C20H40O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(22)23-19-18-21/h21H,2-19H2,1H3 |
| InChI Key | RFVNOJDQRGSOEL-UHFFFAOYSA-N |
| NACRES Code | NA.25 |
| UNSPSC | 12161900 |
| Hazard Symbols | transportation |
| Risk Codes | R36/37/38 |
| Safety Description | S26;S36 |
| MSDS | msds/34436_1_9004_99_3.pdf |
| Bioactivity | Polyoxyethylene stearate (POES) is a non-ionic emulsifying agent. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> P-glycoprotein Research Areas >> Cancer In Vitro Polyoxyethylene stearate has been recommended as an additive to the radiolabelled 7H12 Middlebrook TB media and as such has been shown to enhance growth of mycobacteria in the radiometric BACTEC rapid culture system. Polyoxyethylene (50) stearate produces the greatest enhancement in growth and reduction in the time taken to detect growth for M. tuberculosis and polyoxyethylene (30) stearate and polyoxyethylene (JL) stearate for species of mycobacteria other than M. tuberculosis[1]. Polyoxyethylene stearate inhibits P-gp mediated efflux in a concentration dependent manner mainly by modulating substrate-stimulated P-gp ATPase activity[2]. Polyoxyethylene 40 stearate reduces vinblastine sulfate efllux. The cytotoxicity of vinblastine to K562/ADR cells is significantly enhanced when the cells are cotreated with 100 or 150 μg/mL polyoxyethylene 40 stearate[3]. In Vivo Polyoxyethylene stearate is potentially useful as a pharmaceutical ingredient to improve the oral bioavailability of coadministered P-gp substrates and substrates for certain CYP isoforms[2]. The average tumor volume and average tumor weight are significantly less in the polyoxyethylene 40 stearate+vinblastine group. The inhibition rate for tumor growth is increased from 0.06 (vinblastine group) to 0.84 (vinblastine+polyoxyethylene 40 stearate group)[3]. Cell Assay Polyoxyethylene 40 stearate is added to the test vinblastine solution. The cytotoxicity of vinblastine to K562/ADR cells is then assessed. The final concentrations of polyoxyethylene 40 stearate are 0, 50, 100, and 150 μg/mL. After 8 hours of treatment, cells are incubated for 4 hours in the presence of MTT reagent and then lysed with DMSO. Absorbance is measured at 490 nM[3]. Animal Admin Mice: Polyoxyethylene 40 stearate and vinblastine are dissolved in 0.9% sodium chloride solution, yielding a solution of 200 μg/mL VBL and 150 μg/mL PS40. The drug is injected subcutaneously in a volume of 0.1 mL per 10 g of body weight at a dosage of 2 mg/kg vinblastine and 1.5 mg/kg polyoxyethylene 40 stearate around the tumor every other day for 8 days. The volume of tumors and the weight of mice are measured every day from the day the tumors are formed[3]. References [1]. Cutler RR, et al. The effect of polyoxyethylene stearate (POES) on the growth of mycobacteria in radiometric 7H12 Middlebrook TB medium. Tubercle. 1987 Sep;68(3):209-20. [2]. Zhu S, et al. Effects of polyoxyethylene (40) stearate on the activity of P-glycoprotein and cytochrome P450. Eur J Pharm Sci. 2009 Jul 12;37(5):573-80. [3]. Luo L, et al. Polyoxyethylene 40 stearate modulates multidrug resistance and enhances antitumor activity of vinblastine sulfate. AAPS J. 2007 Oct 5;9(3):E329-35. Chemical & Physical Properties Density 0.9±0.1 g/cm3 Boiling Point 438.4±18.0 °C at 760 mmHg Melting Point 47ºC Molecular Formula C20H40O3 Molecular Weight 328.530 Flash Point 164.6±14.0 °C Exact Mass 328.297760 PSA 46.53000 LogP 7.85 Vapour Pressure 0.0±2.4 mmHg at 25°C Index of Refraction 1.457 |
| Use of | Polyoxyethylene stearate (POES) is a non-ionic emulsifying agent. Properties Articles31 Name Polyethylene Glycol Monostearate N-2 Synonym More Synonyms Polyoxyethylene stearate Biological Activity Description Polyoxyethylene stearate (POES) is a non-ionic emulsifying agent. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> P-glycoprotein Research Areas >> Cancer In Vivo Polyoxyethylene stearate is potentially useful as a pharmaceutical ingredient to improve the oral bioavailability of coadministered P-gp substrates and substrates for certain CYP isoforms[2]. The average tumor volume and average tumor weight are significantly less in the polyoxyethylene 40 stearate+vinblastine group. The inhibition rate for tumor growth is increased from 0.06 (vinblastine group) to 0.84 (vinblastine+polyoxyethylene 40 stearate group)[3]. References [1]. Cutler RR, et al. The effect of polyoxyethylene stearate (POES) on the growth of mycobacteria in radiometric 7H12 Middlebrook TB medium. Tubercle. 1987 Sep;68(3):209-20. [2]. Zhu S, et al. Effects of polyoxyethylene (40) stearate on the activity of P-glycoprotein and cytochrome P450. Eur J Pharm Sci. 2009 Jul 12;37(5):573-80. [3]. Luo L, et al. Polyoxyethylene 40 stearate modulates multidrug resistance and enhances antitumor activity of vinblastine sulfate. AAPS J. 2007 Oct 5;9(3):E329-35. Chemical & Physical Properties Molecular Formula C20H40O3 Exact Mass 328.297760 PSA 46.53000 Index of Refraction 1.457 |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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