CAS Number9003-11-6
Synonyms3-Acetoxy-2,2-bis(acetoxymethyl)propyl acetate; Poloxamer 407; MFCD00082049; Pentaerythrityl Tetraacetate; PAG; Poloxamer; 2,2-Bis[(acetyloxy)methyl]-1,3-propanediol Diacetate; 1,3-Propanediol, 2,2-bis[(acetyloxy)methyl]-, diacetate; Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol); Tetra-O-acetylpentaerythritol; pentaerythritol tetraacetate
Molecular Formula(C3H6O·C2H4O)x
Molecular Weight304.293
Purity98.00%
Density1.2±0.1 g/cm3
Boiling Point370.7±37.0 °C at 760 mmHg
Melting Point60-50ºC
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 9003-11-6 |
| Catalog No. | 2A-9034403 |
| Chinese Name | 泊洛沙姆188 |
| Synonyms | 3-Acetoxy-2,2-bis(acetoxymethyl)propyl acetate; Poloxamer 407; MFCD00082049; Pentaerythrityl Tetraacetate; PAG; Poloxamer; 2,2-Bis[(acetyloxy)methyl]-1,3-propanediol Diacetate; 1,3-Propanediol, 2,2-bis[(acetyloxy)methyl]-, diacetate; Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol); Tetra-O-acetylpentaerythritol; pentaerythritol tetraacetate |
| Molecular Formula | (C3H6O·C2H4O)x |
| Molecular Weight | 304.293 |
| Purity | 98.00 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 370.7±37.0 °C at 760 mmHg |
| Melting Point | 60-50ºC |
| Appearance | powder |
| Water Solubility | H2O: at <70 °Csoluble |
| Storage Condition | Sealed at room temperature, protected from light, |
| Application | Poloxamer 407 is a non-ionic surfactant. Poloxamer 407 is 100% active and relatively non-toxic to cells. It is often used together with dye AM ester to enhance its water solubility. |
| HTC | 39059100 |
| PubChem ID | 24897874 |
| MDL Number | MFCD00082049 |
| SMILES | O2C(C2)C.O1CC1 |
| InChI | 1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2 |
| InChI Key | RVGRUAULSDPKGF-UHFFFAOYSA-N |
| NACRES Code | NA.75 |
| UNSPSC | 12161902 |
| Hazard Symbols | transportation |
| MSDS | msds/34403_1_9003_11_6.pdf |
| Bioactivity | Poloxamer 407 is a nonionic surfactant that is 100% active and relatively non-toxic to cells at low concentrations, and frequently used with dye AM esters such as Indo-1 AM, Fura-2 AM, Calcein AM, Fluo-3 AM, Fluo-4 AM, Quest Fluo-8™ AM and Quest Rhod-4™ AM, etc. to improve their water solubility. Related Catalog Research Areas >> Others Signaling Pathways >> Others >> Others In Vitro Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs). 1. Dissolve 1 g of Poloxamer 407 in 10 mL distilled water to make a 10% (w/v) stock solution, or 2 g of Poloxamer 407 in 10 mL DMSO to make a 20% (w/v) stock solution. These may require heating from 40 to 50°C for about 30 minutes. Store solution at room temperature. Do not refrigerate or freeze the Poloxamer 407 solution since it may precipitate. If precipitation is observed, the precipitates can be dissolved by heating to 37°C and vortexing before use. 2. Dilute the 10% or 20% Poloxamer 407 stock solution into the cell-loading buffer such as Hanks and 20 mM Hepes buffer (HHBS) at 1:1000 to 1:500 dilution to achieve a 0.02 to 0.04% working solution. 3. The DMSO stock solution of AM ester is then diluted into the 0.02 to 0.04% working solution to achieve a final AM ester concentration between 1 μM and 10 μM. The final concentration of Poloxamer 407 is normally kept at or below 0.08%. 4. The cells are incubated at a desired temperature for between 10 minutes and 1 hour. In general it is desirable to use the minimum amount of AM ester needed to achieve adequate fluorescence signal to noise levels. 5. After labeling, the cells are washed with HHBS or fresh medium before starting the experiment. References [1]. Antunes FE, et al. Gels of Pluronic F127 and nonionic surfactants from rheological characterization to controlled drug permeation. Colloids Surf B Biointerfaces. 2011 Oct 1;87(1):42-8. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 370.7±37.0 °C at 760 mmHg Melting Point 60-50ºC Molecular Formula C13H20O8 Molecular Weight 304.293 Flash Point 160.5±26.5 °C Exact Mass 304.115814 PSA 25.06000 LogP 0.00 Vapour density >1 (vs air) Vapour Pressure 0.0±0.8 mmHg at 25°C Index of Refraction 1.452 Storage condition 2-8°C Water Solubility H2O: at <70 °Csoluble |
| Use of | Poloxamer 407 is a nonionic surfactant that is 100% active and relatively non-toxic to cells at low concentrations, and frequently used with dye AM esters such as Indo-1 AM, Fura-2 AM, Calcein AM, Fluo-3 AM, Fluo-4 AM, Quest Fluo-8™ AM and Quest Rhod-4™ AM, etc. to improve their water solubility. Properties Articles44 Name Polyethylene-polypropylene glycol Synonym More Synonyms Polyethylene-polypropylene glycol Biological Activity Description Poloxamer 407 is a nonionic surfactant that is 100% active and relatively non-toxic to cells at low concentrations, and frequently used with dye AM esters such as Indo-1 AM, Fura-2 AM, Calcein AM, Fluo-3 AM, Fluo-4 AM, Quest Fluo-8™ AM and Quest Rhod-4™ AM, etc. to improve their water solubility. Related Catalog Research Areas >> Others Signaling Pathways >> Others >> Others References [1]. Antunes FE, et al. Gels of Pluronic F127 and nonionic surfactants from rheological characterization to controlled drug permeation. Colloids Surf B Biointerfaces. 2011 Oct 1;87(1):42-8. Chemical & Physical Properties Molecular Formula C13H20O8 Exact Mass 304.115814 PSA 25.06000 Vapour density >1 (vs air) Index of Refraction 1.452 |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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