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Iron saccharate structure, CAS 8047-67-4

Iron saccharate

CAS Number8047-67-4

SynonymsVenofer; ferrivenin; Sucrofer; EINECS 232-464-7; MFCD00166305; Fesin; Hippiron; Iron(3+) D-glucarate (2:3); ironsugar; iviron; proferrin; feojectin

Molecular FormulaC18H24Fe2O24

Molecular Weight736.059

Purity98.00%

Density

Boiling Point766.4ºC at 760 mmHg

Melting PointMORE THAN 51ºC

Flash Point

Appearance

EINECS232-464-7

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Symbol

Signal Word

Cat. No.: 2A-9034335 Purity: 98.00%
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Quality Control of [ 8047-67-4 ] Purity: 98.00% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number8047-67-4
Catalog No.2A-9034335
Chinese Name蔗糖铁
SynonymsVenofer; ferrivenin; Sucrofer; EINECS 232-464-7; MFCD00166305; Fesin; Hippiron; Iron(3+) D-glucarate (2:3); ironsugar; iviron; proferrin; feojectin
Molecular FormulaC18H24Fe2O24
Molecular Weight736.059
Purity98.00
Boiling Point766.4ºC at 760 mmHg
Melting PointMORE THAN 51ºC
Storage Conditionroom temperature, dry
ApplicationIron sucrose (Iron saccharate) is an intravenous iron preparation and a pro-oxidant. Iron sucrose can be used in the study of iron deficiency anemia.
EINECS232-464-7
HTC3004909090
SMILESO=C([O-])C(O)C(O)C(O)C(O)C(=O)[O-].O=C([O-])C(O)C(O)C(O)C(O)C(=O)[O-].O=C([O-])C(O)C(O)C(O)C(O)C(=O)[O-].[Fe+3].[Fe+3]
InChI KeyADQSUDSYBZBMFT-UHFFFAOYSA-H
Use ofIron sucrose (Iron saccharate) is a intravenous iron preparation and a pro-oxidant agent. Iron sucrose has the potential for iron deficiency anemia treatment[1][2][3][4]. Properties Name Iron saccharate Synonym More Synonyms Iron sucrose Biological Activity Description Iron sucrose (Iron saccharate) is a intravenous iron preparation and a pro-oxidant agent. Iron sucrose has the potential for iron deficiency anemia treatment[1][2][3][4]. Related Catalog Research Areas >> Metabolic Disease In Vivo Iron sucrose significantly increases tissue superoxide production, expression of tissue cell adhesion molecules, and endothelial adhesiveness in mice with subtotal nephrectomy. Iron sucrose exacerbates atherosclerosis in the aorta of ApoE-/- mice with uninephrectomy[3]. References [1]. Kristiyana Kaneva, et al. Intravenous Iron Sucrose for Children With Iron Deficiency Anemia. J Pediatr Hematol Oncol. 2017 Jul;39(5):e259-e262. [2]. Kristin E Brandt, et al. Augmentation of Intracellular Iron Using Iron Sucrose Enhances the Toxicity of Pharmacological Ascorbate in Colon Cancer Cells. Redox Biol. 2018 Apr;14:82-87. [3]. Ko-Lin Kuo, et al. Iron Sucrose Accelerates Early Atherogenesis by Increasing Superoxide Production and Upregulating Adhesion Molecules in CKD. J Am Soc Nephrol. 2014 Nov;25(11):2596-606. [4]. Richard A Zager, et al. Combined Iron Sucrose and Protoporphyrin Treatment Protects Against Ischemic and Toxin-Mediated Acute Renal Failure. Kidney Int. 2016 Jul;90(1):67-76. Chemical & Physical Properties Molecular Formula C18H24Fe2O24 Exact Mass 735.935608 PSA 483.54000 InChIKey ADQSUDSYBZBMFT-UHFFFAOYSA-H SMILES O=C([O-])C(O)C(O)C(O)C(O)C(=O)[O-].O=C([O-])C(O)C(O)C(O)C(O)C(=O)[O-].O=C([O-])C(O)C(O)C(O)C(O)C(=O)[O-].[Fe+3].[Fe+3] Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Iron oxide, saccharated CAS REGISTRY NUMBER : LAST UPDATED : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,193,1982 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 10,375,1955 ** TUMORIGENIC DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Reproductive - Tumorigenic effects - other reproductive system tumors REFERENCE : BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 60,708,1989 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Tumorigenic - tumors at site of application REFERENCE : BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 1,947,1959 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application REFERENCE : JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 24,109,1960 TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - lymphoma, including Hodgkin's disease Tumorigenic - tumors at site of application REFERENCE : Safety Information HS Code 3004909090
Transport InfoProduct name: Iron sucrose
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