CAS Number7562-61-0
SynonymsUsnic acid; EINECS 231-456-0; (+)-Usniacin; (9bR)-2,6-Diacetyl-1,7,9-trihydroxy-8,9b-dimethyldibenzo[b,d]furan-3(9bH)-one; MFCD00016878; D-Usnic acid
Molecular FormulaC18H16O7
Molecular Weight344.32
Purity98%
Density1.5±0.1 g/cm3
Boiling Point638.2±55.0 °C at 760 mmHg
Melting Point201-203 °C (lit.)
Appearancepowder
EINECS231-456-0
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 7562-61-0 |
| Catalog No. | 2A-9033801 |
| Chinese Name | 松萝酸 |
| Synonyms | Usnic acid; EINECS 231-456-0; (+)-Usniacin; (9bR)-2,6-Diacetyl-1,7,9-trihydroxy-8,9b-dimethyldibenzo[b,d]furan-3(9bH)-one; MFCD00016878; D-Usnic acid |
| Molecular Formula | C18H16O7 |
| Molecular Weight | 344.32 |
| Purity | 98 |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 638.2±55.0 °C at 760 mmHg |
| Melting Point | 201-203 °C (lit.) |
| Appearance | powder |
| Storage Condition | Sealed in a cool, dry environment at 2-8ºC. |
| Application | (+)-Usnic acid is an active ingredient in lichen, which can bind to the ATP-binding pocket of mTOR and inhibit the activity of mTORC1/2. (+)-Usnic acid can inhibit the phosphorylation levels of mTOR d |
| EINECS | 231-456-0 |
| HTC | 2917399090 |
| PubChem ID | 24859825 |
| MDL Number | MFCD00191041 |
| SMILES | C[C@](C1=C(O)C(C)=C(O)C(C(C)=O)=C1O2)(C(C3C(C)=O)=O)C2=CC3=O |
| InChI | 1S/C18H16O7/c1-6-14(22)12(8(3)20)16-13(15(6)23)18(4)10(25-16)5-9(21)11(7(2)19)17(18)24/h5,22-24H,1-4H3/t18-/m1/s1 |
| InChI Key | ICTZCAHDGHPRQR-GOSISDBHSA-N |
| Beilstein/REAXYS | 96698 |
| NACRES Code | NA.22 |
| UNSPSC | 12352106 |
| MSDS | msds/33801_1_7562_61_0.pdf |
| Use of | Properties Name (+)-usnic acid Synonym More Synonyms Usnic acid Biological Activity Related Catalog Signaling Pathways >> PI3K/Akt/mTOR >> mTOR Research Areas >> Cancer References [1]. Ebrahim HY, et al. Usnic Acid Benzylidene Analogues as Potent Mechanistic Target of Rapamycin Inhibitors for the Control of Breast Malignancies. J Nat Prod. 2017 Apr 28;80(4):932-952. Chemical & Physical Properties Molecular Formula C18H16O7 Exact Mass 344.089600 PSA 121.13000 Index of Refraction 1.679 InChIKey WEYVVCKOOFYHRW-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 3(9bH)-dibenzofuranone, 2,6-diacetyl-1,7,9-trihydroxy-8,9b-dimethyl-, D- CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C18-H16-O7 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532, Japan) V.29- 1970- Volume(issue)/page/year: 31,247,1972 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : 1500 ug/kg SEX/DURATION : female 1 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) REFERENCE : NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 176,249,1955 Safety Information Signal Word Warning Hazard Statements H302 Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves Hazard Codes Xn Risk Phrases R22 Safety Phrases S36 RIDADR NONH for all modes of transport WGK Germany 3 RTECS HP5295050 HS Code 2917399090 |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2917399090 aromatic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives. Supervision conditions:None. VAT: 17.0%. Tax rebate rate:9.0%. MFN tariff: 6.5%. General tariff:30.0% |
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