CAS Number7488-99-5
SynonymsCISALPHA-CAROTENE; Carotene; Renieratene; (6'R)-beta,epsilon-carotene; Isorenieratene; A-CAROTENE; MFCD00136012; CAROTENE,A; α-Carotene; all-trans-α-carotene; 4,5-Didehydro-5,6-dihydro-β,β-carotene; (+)-α-Carotene
Molecular FormulaC40H56
Molecular Weight536.87
Purity≥97.0 (HPLC)%
Density0.9±0.1 g/cm3
Boiling Point644.9±35.0 °C at 760 mmHg
Melting Point183-185 °C
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 7488-99-5 |
| Catalog No. | 2A-9033740 |
| Chinese Name | α-胡萝卜素 |
| Synonyms | CISALPHA-CAROTENE; Carotene; Renieratene; (6'R)-beta,epsilon-carotene; Isorenieratene; A-CAROTENE; MFCD00136012; CAROTENE,A; α-Carotene; all-trans-α-carotene; 4,5-Didehydro-5,6-dihydro-β,β-carotene; (+)-α-Carotene |
| Molecular Formula | C40H56 |
| Molecular Weight | 536.87 |
| Purity | ≥97.0 (HPLC) |
| Density | 0.9±0.1 g/cm3 |
| Boiling Point | 644.9±35.0 °C at 760 mmHg |
| Melting Point | 183-185 °C |
| Storage Condition | Sealed in a cool, dry environment |
| Packaging | II; III |
| Application | Alpha-Carotene is a precursor of vitamin A and is used as an antimetastatic agent or as an adjuvant in anticancer drugs. α-Carotene is isolated from orange-yellow and dark green vegetables. |
| PubChem ID | 329757647 |
| MDL Number | MFCD00136012 |
| SMILES | CC(/C=C/[C@H]1C(C)=CCCC1(C)C)=C\C=C\C(C)=C\C=C\C=C(C)\C=C\C=C(\C=C\C2=C(C)CCCC2(C)C)C |
| InChI | 1S/C40H56/c1-31(19-13-21-33(3)25-27-37-35(5)23-15-29-39(37,7)8)17-11-12-18-32(2)20-14-22-34(4)26-28-38-36(6)24-16-30-40(38,9)10/h11-14,17-23,25-28,37H,15-16,24,29-30H2,1-10H3/b12-11+,19-13+,20-14+,27-25+,28-26+,31-17+,32-18+,33-21+,34-22+/t37-/m0/s1 |
| InChI Key | ANVAOWXLWRTKGA-NTXLUARGSA-N |
| Beilstein/REAXYS | 3227603 |
| NACRES Code | NA.24 |
| UNSPSC | 85151701 |
| Hazard Symbols | 4.1 |
| MSDS | msds/33740_1_7488_99_5.pdf |
| Bioactivity | α-Carotene, a precursor of vitamin A, is used as an anti-metastatic agent or as an adjuvant for anti-cancer drugs. α-Carotene is isolated from yellow-orange and dark-green vegetables[1][2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Others >> Others In Vitro α-Carotene (0.5-2.5 μM; 24 hours) significantly increases protein expression of TIMP-1 and TIMP-2 in a concentration-dependent manner in LLC cells. AC (0.5-2.5 μM) significantly increases PAI-1 protein expression. α-Carotene (2.5 μM) also significantly inhibits integrin β1-mediated phosphorylation of focal adhesion kinase (FAK) which then decreased the phosphorylation of MAPK family[2]. α-Carotene (0.5, 1, 2.5 μM; 48 hours) significantly and concentration-dependently inhibits invasion of LLC during 48 h of incubation[2]. α-Carotene (0.5, 1, 2.5 μM; 24 hours) significantly decreases activities of MMP-9, -2 and uPA in concentration-dependent manner in LLC cells[2]. α-Carotene (2, 5, 10 μM; 7 days) inhibits the proliferation of the human neuroblastoma cell line GOTO in a dose- and time-dependent manner. α-Carotene (5 μM; 48 hours) halts the cell cycle at the G0/G1 phase concomitantly with a reduction in the mRNA expression of the protooncogene N-Myc[3]. Western Blot Analysis[2] Cell Line: Lewis lung carcinoma (LLC) cells Concentration: 0.5, 1, 2.5 μM Incubation Time: 24 hours Result: Significantly increased protein expression of TIMP-1 and TIMP-2 in a concentration-dependent manner in LLC cells. In Vivo α-Carotene (5 mg/kg; oral; twice a week; for additional 3 weeks) alone significantly decreases lung metastasis without affecting primary tumor growth[2]. Animal Model: C57BL/6 male mice (4 weeks old; 20-25 g) with LLC cells[2] Dosage: 5 mg/kg Administration: Oral; twice a week; for additional 3 weeks Result: Significantly decreased lung metastasis. References [1]. Bushway, R.J., et al. Determination of α- and β-carotene in fruit and vegetables by high performance liquid chromatography. Can. Inst. Food Sci. Technol. J. 15(3), 165-169 (1982). [2]. Liu YZ, et al. Alpha-carotene inhibits metastasis in Lewis lung carcinoma in vitro, and suppresses lungmetastasis and tumor growth in combination with taxol in tumor xenografted C57BL/6 mice. J Nutr Biochem. 2015 Jun;26(6):607-15. [3]. Murakoshi M, et al. Inhibitory effects of alpha-carotene on proliferation of the human neuroblastoma cell line GOTO. J Natl Cancer Inst. 1989 Nov 1;81(21):1649-52. Chemical & Physical Properties Density 0.9±0.1 g/cm3 Boiling Point 644.9±35.0 °C at 760 mmHg Melting Point 185ºC Molecular Formula C40H56 Molecular Weight 536.873 Flash Point 341.2±20.8 °C Exact Mass 536.438232 LogP 15.45 Vapour Pressure 0.0±0.9 mmHg at 25°C Index of Refraction 1.563 InChIKey ANVAOWXLWRTKGA-CBHOHNDZSA-N SMILES CC(C=CC=C(C)C=CC1=C(C)CCCC1(C)C)=CC=CC=C(C)C=CC=C(C)C=CC1C(C)=CCCC1(C)C Storage condition -20°C |
| Use of | α-Carotene, a precursor of vitamin A, is used as an anti-metastatic agent or as an adjuvant for anti-cancer drugs. α-Carotene is isolated from yellow-orange and dark-green vegetables[1][2]. Properties Name (6'R)-β,ε-carotene Synonym More Synonyms α-Carotene Biological Activity Description α-Carotene, a precursor of vitamin A, is used as an anti-metastatic agent or as an adjuvant for anti-cancer drugs. α-Carotene is isolated from yellow-orange and dark-green vegetables[1][2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Others >> Others References [1]. Bushway, R.J., et al. Determination of α- and β-carotene in fruit and vegetables by high performance liquid chromatography. Can. Inst. Food Sci. Technol. J. 15(3), 165-169 (1982). [3]. Murakoshi M, et al. Inhibitory effects of alpha-carotene on proliferation of the human neuroblastoma cell line GOTO. J Natl Cancer Inst. 1989 Nov 1;81(21):1649-52. Chemical & Physical Properties Molecular Formula C40H56 Exact Mass 536.438232 LogP 15.45 Index of Refraction 1.563 InChIKey ANVAOWXLWRTKGA-CBHOHNDZSA-N |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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