CAS Number7460-82-4
SynonymsEthanol, 2,2'-oxybis-, bis(4-methylbenzenesulfonate); Oxydi-2,1-ethanediyl bis(4-methylbenzenesulfonate); oxydiethane-2,1-diyl bis(4-methylbenzenesulfonate); MFCD00026001; 2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethyl 4-methylbenzenesulfonate
Molecular Formula(CH3C6H4SO3CH2CH2)2O
Molecular Weight414.49
Purity98%
Density1.3±0.1 g/cm3
Boiling Point581.2±45.0 °C at 760 mmHg
Melting Point87-89 °C (lit.)
Appearancesolid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 7460-82-4 |
| Catalog No. | 2A-9033710 |
| Chinese Name | 二乙二醇双(对甲苯磺酸酯) |
| Synonyms | Ethanol, 2,2'-oxybis-, bis(4-methylbenzenesulfonate); Oxydi-2,1-ethanediyl bis(4-methylbenzenesulfonate); oxydiethane-2,1-diyl bis(4-methylbenzenesulfonate); MFCD00026001; 2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethyl 4-methylbenzenesulfonate |
| Molecular Formula | (CH3C6H4SO3CH2CH2)2O |
| Molecular Weight | 414.49 |
| Purity | 98 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 581.2±45.0 °C at 760 mmHg |
| Melting Point | 87-89 °C (lit.) |
| Appearance | solid |
| Storage Condition | Sealed in a cool, dry environment |
| Application | Diethylene glycol bis(p-toluenesulfonate) is a PROTAC linker, belonging to the PEG class. Can be used to synthesize PROTAC molecules. |
| HTC | 2904100000 |
| PubChem ID | 24860605 |
| MDL Number | MFCD00026001 |
| SMILES | Cc1ccc(cc1)S(=O)(=O)OCCOCCOS(=O)(=O)c2ccc(C)cc2 |
| InChI | 1S/C18H22O7S2/c1-15-3-7-17(8-4-15)26(19,20)24-13-11-23-12-14-25-27(21,22)18-9-5-16(2)6-10-18/h3-10H,11-14H2,1-2H3 |
| InChI Key | VYVPNTJBGPQTFA-UHFFFAOYSA-N |
| Beilstein/REAXYS | 583800 |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| Hazard Symbols | transportation |
| MSDS | msds/33710_1_7460_82_4.pdf |
| Bioactivity | Diethylene glycol bis(p-toluenesulfonate) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker Target PEGs In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. References [1]. Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 581.2±45.0 °C at 760 mmHg Melting Point 87-89 °C(lit.) Molecular Formula C18H22O7S2 Molecular Weight 414.493 Flash Point 305.3±28.7 °C Exact Mass 414.080688 PSA 112.73000 LogP 2.70 Vapour Pressure 0.0±1.6 mmHg at 25°C Index of Refraction 1.554 InChIKey VYVPNTJBGPQTFA-UHFFFAOYSA-N SMILES Cc1ccc(S(=O)(=O)OCCOCCOS(=O)(=O)c2ccc(C)cc2)cc1 |
| Use of | Diethylene glycol bis(p-toluenesulfonate) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Properties Name Oxybis(ethane-2,1-diyl) bis(4-methylbenzenesulfonate) Synonym More Synonyms Biological Activity Description Diethylene glycol bis(p-toluenesulfonate) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. References [1]. Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34. Chemical & Physical Properties Molecular Formula C18H22O7S2 Exact Mass 414.080688 PSA 112.73000 Index of Refraction 1.554 InChIKey VYVPNTJBGPQTFA-UHFFFAOYSA-N |
| Tax Rebate | 9.0% |
| Supervision | none |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available The above information is believed to be correct, but is not all-inclusive and should be used as a guide only. The information in this document is based on our current knowledge and is Correct safety instructions apply to this product. This information does not represent a warranty as to the properties of this product. See reverse side of invoice or packing slip. |
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