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Home > Products > Specialty & Industrial Chemicals > Specialty Chemicals > 2-Methyl-2-thiopseudourea sulfate
2-Methyl-2-thiopseudourea sulfate structure, CAS 867-44-7

2-Methyl-2-thiopseudourea sulfate

CAS Number867-44-7

SynonymsS-Methyl-isothiouronium Hemisulfate; S-METHYLTHIOPSEUDOUREA SULPHATE; 2-Methyl-2-thiopseudourea sulfate; 2-Methyl-2-thiopseudourea hemisulfate; S-METHYLISOTHIOHARNSTOFF HEMISULFAT; S-methylisothiourea sulfuric acid salt 1:1; S-EIT hemihydrate; 2-methyl-2-thiopseudouronium sulfate; S-METHYLISOTHIOURONIUM SULPHATE; 2-Methyl-2-thiopseudoureasulfate; S-METHYL-ISO-THIOUREA SULFATE; S-Methylisothiourea Hemisulfate Salt; S-METHYLISOTHIOURONIUM SULPHATE/S-METHYLISOTHIOUREA SULPHATE/2-METHYL-2-THIOPSEUDOUREA SULPHATE; 2-METHYL-2-THIOPSEUDOUREA SULFATE (S-METHYLISOTHIOUREA SULFATE); MFCD00129752; methyl imidothiocarbamate; S-METHYL ISOTHIOUREA SULFATE; Carbamimidothioic acid, methyl ester, sulfate (2:1); S-methyl-2-thiopseudourea hydrogen sulfate; S-METHYLTHIOURONIUM SULFATE; S-methylisothiourea hyd

Molecular FormulaHN=C(NH2)SCH3 · 1/2H2SO4

Molecular Weight139.19

Purity98%

Density1.28

Boiling Point138.8ºC at 760 mmHg

Melting Point240-241 °C (dec.) (lit.)

Flash Point

Appearancecrystals

EINECS212-759-7

MSDSChineseEnglish

SymbolTransport

Signal WordWarning

Cat. No.: 2A-9003371 Purity: 98%
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Quality Control of [ 867-44-7 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number867-44-7
Catalog No.2A-9003371
Chinese Name|S|-甲基异硫脲硫酸盐
SynonymsS-Methyl-isothiouronium Hemisulfate; S-METHYLTHIOPSEUDOUREA SULPHATE; 2-Methyl-2-thiopseudourea sulfate; 2-Methyl-2-thiopseudourea hemisulfate; S-METHYLISOTHIOHARNSTOFF HEMISULFAT; S-methylisothiourea sulfuric acid salt 1:1; S-EIT hemihydrate; 2-methyl-2-thiopseudouronium sulfate; S-METHYLISOTHIOURONIUM SULPHATE; 2-Methyl-2-thiopseudoureasulfate; S-METHYL-ISO-THIOUREA SULFATE; S-Methylisothiourea Hemisulfate Salt; S-METHYLISOTHIOURONIUM SULPHATE/S-METHYLISOTHIOUREA SULPHATE/2-METHYL-2-THIOPSEUDOUREA SULPHATE; 2-METHYL-2-THIOPSEUDOUREA SULFATE (S-METHYLISOTHIOUREA SULFATE); MFCD00129752; methyl imidothiocarbamate; S-METHYL ISOTHIOUREA SULFATE; Carbamimidothioic acid, methyl ester, sulfate (2:1); S-methyl-2-thiopseudourea hydrogen sulfate; S-METHYLTHIOURONIUM SULFATE; S-methylisothiourea hyd
Molecular FormulaHN=C(NH2)SCH3 · 1/2H2SO4
Molecular Weight139.19
Purity98
Density1.28
Boiling Point138.8ºC at 760 mmHg
Melting Point240-241 °C (dec.) (lit.)
Appearancecrystals
Water Solubility260 g/L (20 ºC)
Storage ConditionKeep container sealed and stored in a cool, dry pl
ApplicationS-Methylisothiourea sulfate is a highly potent, selective, and competitive inhibitor of inducible nitric oxide synthase (iNOS). S-Methylisothiourea sulfate exerts beneficial effects in rodent models o
EINECS212-759-7
HTC2930909090
PubChem ID24897262
MDL NumberMFCD00013055
SMILESCSC(N)=N.CSC(N)=N.OS(O)(=O)=O
InChI1S/2C2H6N2S.H2O4S/c2*1-5-2(3)4;1-5(2,3)4/h2*1H3,(H3,3,4);(H2,1,2,3,4)
InChI KeyBZZXQZOBAUXLHZ-UHFFFAOYSA-N
Beilstein/REAXYS3717365
NACRES CodeNA.22
UNSPSC12352100
Hazard SymbolsTransport
MSDSmsds/3371_1_867_44_7.pdf
BioactivityS-Methylisothiourea sulfate is a potent, selective and competitive inhibitor of inducible nitric oxide synthase (iNOS). S-Methylisothiourea sulfate exerts beneficial effects in rodent models of septic shock[1]. Related Catalog Research Areas >> Infection Signaling Pathways >> Immunology/Inflammation >> NO Synthase Target iNOS[1] In Vitro S-Methylisothiourea sulfate is a competitive inhibitor of iNOS activity at the L-arginine site[1]. S-Methylisothiourea sulfate prevents the NO-mediated cytotoxic effect of LPS in cultured macrophages[1]. S-Methylisothiourea sulfate (100 nM-100 μM) exhibits inhibitory effects on LPS (ug/mL)-induced nitrite production in J774.2 macrophages and rat aortic vascular smooth muscle cells[1]. S-Methylisothiourea sulfate(up to 1 mM) does not inhibit the activity of xanthine oxidase, diaphorase, lactate dehydrogenase, monoamine oxidase, catalase, cytochrome P450, or superoxide dismutase[1]. In Vivo S-Methylisothiourea sulfate (0.01-3 mg/kg; i.v.) dose-dependently reverses the hypotension and the vascular hyporeactivity to vasoconstrictor agents caused by endotoxin LPS in anesthetized rats[1]. S-Methylisothiourea sulfate (5 mg/kg; i.p.; given 2 hr after LPS; 10 mg/kg, i.p.) attenuates the rises in plasma alanine and aspartate aminotransferases, bilirubin, and creatinine and also prevents hypocalcaemia when measured 6 hr after administration of LPS[1]. S-Methylisothiourea sulfate (1 mg/kg; i.p.) improves 24-hr survival of mice treated with a high dose of LPS (60 mg/kg; i.p.)[1]. Animal Model: Male Wistar rats (260-320 g)[1] Dosage: 0.01 mg/kg, 0.1 mg/kg, 1 mg/kg, 3 mg/kg Administration: Intravenous injection Result: Caused a prompt restoration of the blood pressure to pre-LPS levels at 3 mg/kg dose in LPS (10 mg/kg, i.v.)-treated rats; Inhibits iNOS activity measured in homogenates of lung. References [1]. C Szabó, et al. Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase. Proc Natl Acad Sci U S A. 1994 Dec 20; 91(26): 12472-12476. Chemical & Physical Properties Density 1.28 Boiling Point 138.8ºC at 760 mmHg Melting Point 240-241 °C (dec.)(lit.) Molecular Formula C2H8N2O4S2 Molecular Weight 188.226 Flash Point 37.7ºC Exact Mass 187.992554 PSA 158.15000 LogP 1.47090 InChIKey NNBBQNFHCVVQHZ-UHFFFAOYSA-N SMILES CSC(=N)N.O=S(=O)(O)O Storage condition Store at RT Stability Stable. Incompatible with strong oxidizing agents. Water Solubility 260 g/L (20 ºC)
Use ofS-Methylisothiourea sulfate is a potent, selective and competitive inhibitor of inducible nitric oxide synthase (iNOS). S-Methylisothiourea sulfate exerts beneficial effects in rodent models of septic shock[1]. Properties Articles41 Name 2-Methyl-2-thiopseudourea sulfate Synonym More Synonyms S-Methylisothiourea sulfate Biological Activity Description S-Methylisothiourea sulfate is a potent, selective and competitive inhibitor of inducible nitric oxide synthase (iNOS). S-Methylisothiourea sulfate exerts beneficial effects in rodent models of septic shock[1]. Related Catalog Research Areas >> Infection Signaling Pathways >> Immunology/Inflammation >> NO Synthase References [1]. C Szabó, et al. Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase. Proc Natl Acad Sci U S A. 1994 Dec 20; 91(26): 12472-12476. Chemical & Physical Properties Molecular Formula C2H8N2O4S2 Exact Mass 187.992554 PSA 158.15000 LogP 1.47090 InChIKey NNBBQNFHCVVQHZ-UHFFFAOYSA-N SMILES CSC(=N)N.O=S(=O)(O)O Storage condition Store at RT Stability Stable. Incompatible with strong oxidizing agents.
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 30.0%
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available
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