CAS Number7423-55-4
SynonymsBMPA; β-Maleimidopropionic acid; MFCD00043030; 3-(2,5-dioxopyrrol-1-yl)propanoic acid; 3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoic acid; 3-Maleimidopropionic acid; 3-Maleimidopropionicacid
Molecular FormulaC7H7NO4
Molecular Weight169.13
Purity97%
Density1.5±0.1 g/cm3
Boiling Point382.5±25.0 °C at 760 mmHg
Melting Point103-106 °C (lit.)
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 7423-55-4 |
| Catalog No. | 2A-9033646 |
| Chinese Name | 3-马来酰亚胺基丙酸 |
| Synonyms | BMPA; β-Maleimidopropionic acid; MFCD00043030; 3-(2,5-dioxopyrrol-1-yl)propanoic acid; 3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoic acid; 3-Maleimidopropionic acid; 3-Maleimidopropionicacid |
| Molecular Formula | C7H7NO4 |
| Molecular Weight | 169.13 |
| Purity | 97 |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 382.5±25.0 °C at 760 mmHg |
| Melting Point | 103-106 °C (lit.) |
| Appearance | powder |
| Water Solubility | Soluble in: methanol |
| Storage Condition | Sealed in a cool, dry environment at -15°C. |
| Application | 3-Maleimidopropionic acid is a PROTAC linker, belonging to the alkyl chain class. Can be used to synthesize PROTAC molecules. |
| HTC | 2925190090 |
| PubChem ID | 24864618 |
| MDL Number | MFCD00043030 |
| SMILES | OC(=O)CCN1C(=O)C=CC1=O |
| InChI | 1S/C7H7NO4/c9-5-1-2-6(10)8(5)4-3-7(11)12/h1-2H,3-4H2,(H,11,12) |
| InChI Key | IUTPJBLLJJNPAJ-UHFFFAOYSA-N |
| Beilstein/REAXYS | 1528952 |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| Hazard Symbols | transportation |
| MSDS | msds/33646_1_7423_55_4.pdf |
| Bioactivity | 3-Maleimidopropionic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker Target Alkyl-Chain In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. References [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 Chemical & Physical Properties Density 1.5±0.1 g/cm3 Boiling Point 382.5±25.0 °C at 760 mmHg Melting Point 103-106 °C(lit.) Molecular Formula C7H7NO4 Molecular Weight 169.135 Flash Point 185.1±23.2 °C Exact Mass 169.037506 PSA 74.68000 LogP 0.04 Vapour Pressure 0.0±1.9 mmHg at 25°C Index of Refraction 1.565 InChIKey IUTPJBLLJJNPAJ-UHFFFAOYSA-N SMILES O=C(O)CCN1C(=O)C=CC1=O Storage condition -15°C |
| Use of | 3-Maleimidopropionic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Properties Articles18 Name 3-Maleimidopropionic Acid Synonym More Synonyms 3-Maleimidopropionic acid Biological Activity Description 3-Maleimidopropionic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker Alkyl-Chain In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. References [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 Chemical & Physical Properties Molecular Formula C7H7NO4 Exact Mass 169.037506 PSA 74.68000 Index of Refraction 1.565 InChIKey IUTPJBLLJJNPAJ-UHFFFAOYSA-N |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 30.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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