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Sodium methotrexate structure, CAS 7413-34-5

Sodium methotrexate

CAS Number7413-34-5

SynonymsMETHOTREXATE DISODIUM; 4-amino-n(sup10)-methylpteroylglutamicaciddisodiumsalt; mtxdisodium; Methotrexate Disodium Salt Solution; Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, sodium salt (1:2); amethopterinsodium; Disodium 2-[(4-{[(2,4-diamino-6-pteridinyl)methyl](methyl)amino}benzoyl)amino]pentanedioate; METHOTREXATUM; disodiummethotrexate; sodium methotrexate; N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamatic acid disodium; l-(+)-isodiumsal

Molecular FormulaC20H20N8Na2O5

Molecular Weight498.40

Purity≥98 (HPLC)%

Density

Boiling Point823℃

Melting Point

Flash Point

Appearancepowder

EINECS

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-9033634 Purity: ≥98 (HPLC)%
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Quality Control of [ 7413-34-5 ] Purity: ≥98 (HPLC)% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number7413-34-5
Catalog No.2A-9033634
Chinese Name甲氨蝶呤二钠盐
SynonymsMETHOTREXATE DISODIUM; 4-amino-n(sup10)-methylpteroylglutamicaciddisodiumsalt; mtxdisodium; Methotrexate Disodium Salt Solution; Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, sodium salt (1:2); amethopterinsodium; Disodium 2-[(4-{[(2,4-diamino-6-pteridinyl)methyl](methyl)amino}benzoyl)amino]pentanedioate; METHOTREXATUM; disodiummethotrexate; sodium methotrexate; N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamatic acid disodium; l-(+)-isodiumsal
Molecular FormulaC20H20N8Na2O5
Molecular Weight498.40
Purity≥98 (HPLC)
Boiling Point823℃
Appearancepowder
Storage ConditionSealed in a cool, dry environment at 0-6ºC.
ApplicationMethotrexate (Amethopterin) disodium is an antimetabolite and antifolate agent that inhibits dihydrofolate reductase, thereby preventing the conversion of folate to tetrahydrofolate and inhibiting DNA
HTC2933990090
MDL NumberMFCD00274560
SMILES[Na].[Na].N([C@@H](CCC(=O)O)C(=O)O)C(=O)c1ccc(cc1)N(Cc2nc3c(nc(nc3N)N)nc2)C
InChIInChI=1S/C20H22N8O5.2Na/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30;;/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27);;/q;2*+1/p-2
InChI KeyHQRCOVOSZPGUCA-GXKRWWSZSA-N
NACRES CodeNA.21
UNSPSC12352200
MSDSmsds/33634_1_7413_34_5.pdf
Use ofMethotrexate (Amethopterin) disodium, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate disodium, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia)[1][2][3]. Properties Name Methotrexate disodium salt Synonym More Synonyms Methotrexate disodium Biological Activity Description Methotrexate (Amethopterin) disodium, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate disodium, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia)[1][2][3]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Antifolate Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin Research Areas >> Inflammation/Immunology Traditional Cytotoxic Agents References [1]. Tian H, et al. Understanding the mechanisms of action of methotrexate: implications for the treatment of rheumatoid arthritis. Bull NYU Hosp Jt Dis. 2007;65(3):168-73. [2]. Swierkot J, et al. Methotrexate in rheumatoid arthritis. Pharmacol Rep. 2006 Jul-Aug;58(4):473-92. [3]. Swierkot J, et al. Methotrexate in rheumatoid arthritis. Pharmacol Rep. 2006 Jul-Aug;58(4):473-92. [4]. Banji D, et al. Evaluation of the concomitant use of methotrexate and curcumin on Freund's complete adjuvant-induced arthritis and hematological indices in rats. Indian J Pharmacol. 2011;43(5):546-550. Chemical & Physical Properties Molecular Formula C20H20N8Na2O5 Exact Mass 498.135193 PSA 216.20000 InChIKey DASQOOZCTWOQPA-GXKRWWSZSA-L Storage condition -20℃ Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Glutamic acid, N-(p-(((2,4-diamino-6-pteridinyl)methyl)methylamino)b enzoyl)-, disodium salt, L-(+)- CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C20-H20-N8-O5.2Na MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 58,735,1977 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SEX/DURATION : male 60 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) REFERENCE : JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 58,735,1977 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5643 No. of Facilities: 4 (estimated) No. of Industries: 1 No. of Occupations: 15 No. of Employees: 1233 (estimated) Safety Information HS Code 2933990090 Synthetic Route Total: 1 Page dicyanomethyl N... CAS#:1379609-57-0 Methotrexate di... CAS#:7413-34-5 Methotrexate CAS#:59-05-2 Methotrexate di... CAS#:7413-34-5 Literature: Journal of Materials Chemistry, , vol. 20, # 42 p. 9463 - 9469 Precursor & DownStream Precursor 1 CAS#:59-05-2 Methotrexate DownStream 1 CAS#:86669-36-5 L-Glutamic acid...
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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