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DIMETHINDENE MALEATE structure, CAS 3614-69-5

DIMETHINDENE MALEATE

CAS Number3614-69-5

SynonymsFenistil-retard; N,N-Dimethyl-2-{3-[1-(2-pyridinyl)ethyl]-1H-inden-2-yl}ethanamine (2Z)-2-butenedioate (1:1); Fenistil; Forthistal maleate; 1H-Indene-2-ethanamine, N,N-dimethyl-3-[1-(2-pyridinyl)ethyl]-, (2Z)-2-butenedioate (1:1); Dimethinden maleate; Forhistal maleate; Dimethpyrindene maleate; Dimethindene maleate; Dimetindene maleate; SU-6518; 3-[a-(2'-Pyridyl)ethyl]-2-(b-dimethylaminoethyl)indene Maleate (1:1); N,N-Dimethyl-2-{3-[1-(pyridin-2-yl)ethyl]-1H-inden-2-yl}ethanamine (2Z)-but-2-enedioate (1:1); dimetindene hydrogen maleate

Molecular FormulaC24H28N2O4

Molecular Weight408.49

Purity98.00%

Density

Boiling Point416.3ºC at 760mmHg

Melting Point159-161℃

Flash Point

Appearance

EINECS

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Symbol

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Cat. No.: 2A-9033564 Purity: 98.00%
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Quality Control of [ 3614-69-5 ] Purity: 98.00% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number3614-69-5
Catalog No.2A-9033564
Chinese Name马来酸二甲茚定
SynonymsFenistil-retard; N,N-Dimethyl-2-{3-[1-(2-pyridinyl)ethyl]-1H-inden-2-yl}ethanamine (2Z)-2-butenedioate (1:1); Fenistil; Forthistal maleate; 1H-Indene-2-ethanamine, N,N-dimethyl-3-[1-(2-pyridinyl)ethyl]-, (2Z)-2-butenedioate (1:1); Dimethinden maleate; Forhistal maleate; Dimethpyrindene maleate; Dimethindene maleate; Dimetindene maleate; SU-6518; 3-[a-(2'-Pyridyl)ethyl]-2-(b-dimethylaminoethyl)indene Maleate (1:1); N,N-Dimethyl-2-{3-[1-(pyridin-2-yl)ethyl]-1H-inden-2-yl}ethanamine (2Z)-but-2-enedioate (1:1); dimetindene hydrogen maleate
Molecular FormulaC24H28N2O4
Molecular Weight408.49
Purity98.00
Boiling Point416.3ºC at 760mmHg
Melting Point159-161℃
Water SolubilitySlightly soluble in water, soluble in methanol
Storage Conditionroom temperature
ApplicationDimethyl maleate is a selective histamine H1 antagonist with antihistamine effects. Dimethyl maleate can be used in the study of hypersensitivity reactions [1][2][3].
HTC2933399090
MDL NumberMFCD00072146
SMILESN(CCC1=C(c3c(cccc3)C1)C(C)c2ncccc2)(C)C.OC(=O)\C=C/C(=O)O
InChI1S/C20H24N2.C4H4O4/c1-15(19-10-6-7-12-21-19)20-17(11-13-22(2)3)14-16-8-4-5-9-18(16)20;5-3(6)1-2-4(7)8/h4-10,12,15H,11,13-14H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
InChI KeySWECWXGUJQLXJF-BTJKTKAUSA-N
NACRES CodeNA.24
UNSPSC41116107
MSDSmsds/33564_1_3614_69_5.pdf
Use ofDimethindene maleate is a selective histamine H1 antagonist with antihistamine effects. Dimethindene maleate can be used for the research of hypersensitivity reactions[1][2][3]. Properties Articles25 Name (Z)-but-2-enedioic acid,N,N-dimethyl-2-[3-(1-pyridin-2-ylethyl)-1H-inden-2-yl]ethanamine Synonym More Synonyms Description Dimethindene maleate is a selective histamine H1 antagonist with antihistamine effects. Dimethindene maleate can be used for the research of hypersensitivity reactions[1][2][3]. Related Catalog Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Human Endogenous Metabolite In Vitro Dimethindene maleate (1-1000 μM) suppresses the cromakalim-induced/glibenclamide-sensitive K＋ currents in a concentration-dependent and reversible manner with an IC50 value of 29.5 μM[2]. Dimethindene maleate (1-1000 μM) inhibits Y-26763-induced glibenclamide-sensitive K＋ currents with an IC50 value of 49 μM[2]. Chemical & Physical Properties Molecular Formula C24H28N2O4 Exact Mass 408.204895 PSA 90.73000 LogP 3.85850 InChIKey SWECWXGUJQLXJF-BTJKTKAUSA-N Water Solubility Slightly soluble in water, soluble in methanol Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : MOLECULAR WEIGHT : WISWESSER LINE NOTATION : L56 BHJ C2N1&1 DY1&- BT6NJ &QV2VQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 3,534,1961 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 26800 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 3,534,1961 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 3,534,1961 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 3,534,1961 Safety Information Hazard Codes Xn HS Code 2933399090
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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