CAS Number7177-48-2
SynonymsAmpicillin; MFCD00072036; EINECS 200-709-7; Ampicillin Trihydrate
Molecular FormulaC16H25N3O7S
Molecular Weight403.46
Purity98.00%
Boiling Point683.9ºC at 760 mmHg
Melting Point208 °C (dec.)(lit.)
AppearanceOdorless white microcrystalline powder with a bitter taste
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 7177-48-2 |
| Catalog No. | 2A-9033468 |
| Chinese Name | 氨苄青霉素,三水 |
| Synonyms | Ampicillin; MFCD00072036; EINECS 200-709-7; Ampicillin Trihydrate |
| Molecular Formula | C16H25N3O7S |
| Molecular Weight | 403.46 |
| Purity | 98.00 |
| Boiling Point | 683.9ºC at 760 mmHg |
| Melting Point | 208 °C (dec.)(lit.) |
| Appearance | Odorless white microcrystalline powder with a bitter taste |
| Water Solubility | 0.1-1 g/100 mL at 21 ºC |
| Storage Condition | Seal in a cool, dry place at 2-8ºC. |
| Application | Ampicillin trihydrate (D-(-)-α-Aminobenzylpenicillin trihydrate) is a broad-spectrum β-lactam antibiotic active against a variety of Gram-positive and Gram-negative bacteria. |
| HTC | 2941101100 |
| MDL Number | C16H19N3O4S·3H2O |
| SMILES | CC1(C)SC2C(NC(=O)C(N)c3ccccc3)C(=O)N2C1C(=O)O.O.O.O |
| InChI | InChI=1S/C16H19N3O4S.3H2O/c1-16(2)11(15(22)23)19-13(21)10(14(19)24-16)18-12(20)9(17)8-6-4-3-5-7-8;;;/h3-7,9-11,14H,17H2,1-2H3,(H,18,20)(H,22,23);3*1H2/t9-,10-,11+,14-;;;/m1.../s1 |
| InChI Key | RXDALBZNGVATNY-CWLIKTDRSA-N |
| Hazard Symbols | transportation |
| MSDS | msds/33468_1_7177_48_2.pdf |
| Bioactivity | Ampicillin trihydrate (D-(-)-α-Aminobenzylpenicillin trihydrate) is a broad-spectrum beta-lactam antibiotic against a variety of gram-positive and gram-negative bacteria. Related Catalog Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial In Vitro Ampicillin trihydrate (D-(-)-α-Aminobenzylpenicillin trihydrate) inhibits the growth of E. coli of swine origin in a dose-dependent manner. The effective inhibitory concentration of Ampicillin trihydrate is 2.5 uG/mL[1]. In Vivo Ampicillin trihydrate (D-(-)-α-Aminobenzylpenicillin trihydrate) is very effective in alleviating the symptoms of hemorrhagic enteritis in a 11-week old pig[1]. Ampicillin trihydrate produces maximum concentrations in bile twice as high as in serum. The peak concentration of ampicillin after an oral dose is as twice as high in portal blood as in peripheral blood[2]. Ampicillin trihydrate provides neuroprotection against ischemia-reperfusion brain injury. Ampicillin trihydrate reduces the activities of MMPs and increases the expression level of GLT-1. Pretreatment with Ampicillin trihydrate significantly reduces medial hippocampal cell death following global forebrain ischemia[3]. References [1]. Chopra SL, et al. Effect of Ampicillin on E. Coli of Swine Origin. Can J Comp Med Vet Sci. 1963 Sep;27(9):223-7. [2]. Lund B, et al. Ampicillin in portal and peripheral blood and bile after oral administration of ampicillin andpivampicillin. Eur J Clin Pharmacol. 1974;7(2):133-5. [3]. Lee KE, et al. The neuroprotective mechanism of ampicillin in a mouse model of transient forebrain ischemia. Korean J Physiol Pharmacol. 2016 Mar;20(2):185-92. Chemical & Physical Properties Boiling Point 683.9ºC at 760 mmHg Melting Point 208 °C (dec.)(lit.) Molecular Formula C16H25N3O7S Molecular Weight 403.451 Flash Point 367.4ºC Exact Mass 403.141327 PSA 165.72000 LogP 1.15430 Index of Refraction 265 ° (C=0.1, H2O) InChIKey RXDALBZNGVATNY-CWLIKTDRSA-N SMILES CC1(C)SC2C(NC(=O)C(N)c3ccccc3)C(=O)N2C1C(=O)O.O.O.O Water Solubility 0.1-1 g/100 mL at 21 ºC |
| Use of | Ampicillin trihydrate (D-(-)-α-Aminobenzylpenicillin trihydrate) is a broad-spectrum beta-lactam antibiotic against a variety of gram-positive and gram-negative bacteria. Properties Articles721 Name ampicillin trihydrate Synonym More Synonyms Ampicillin Trihydrate Biological Activity Description Ampicillin trihydrate (D-(-)-α-Aminobenzylpenicillin trihydrate) is a broad-spectrum beta-lactam antibiotic against a variety of gram-positive and gram-negative bacteria. Related Catalog Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial In Vitro Ampicillin trihydrate (D-(-)-α-Aminobenzylpenicillin trihydrate) inhibits the growth of E. coli of swine origin in a dose-dependent manner. The effective inhibitory concentration of Ampicillin trihydrate is 2.5 uG/mL[1]. In Vivo Ampicillin trihydrate (D-(-)-α-Aminobenzylpenicillin trihydrate) is very effective in alleviating the symptoms of hemorrhagic enteritis in a 11-week old pig[1]. Ampicillin trihydrate produces maximum concentrations in bile twice as high as in serum. The peak concentration of ampicillin after an oral dose is as twice as high in portal blood as in peripheral blood[2]. Ampicillin trihydrate provides neuroprotection against ischemia-reperfusion brain injury. Ampicillin trihydrate reduces the activities of MMPs and increases the expression level of GLT-1. Pretreatment with Ampicillin trihydrate significantly reduces medial hippocampal cell death following global forebrain ischemia[3]. References [1]. Chopra SL, et al. Effect of Ampicillin on E. Coli of Swine Origin. Can J Comp Med Vet Sci. 1963 Sep;27(9):223-7. [2]. Lund B, et al. Ampicillin in portal and peripheral blood and bile after oral administration of ampicillin andpivampicillin. Eur J Clin Pharmacol. 1974;7(2):133-5. [3]. Lee KE, et al. The neuroprotective mechanism of ampicillin in a mouse model of transient forebrain ischemia. Korean J Physiol Pharmacol. 2016 Mar;20(2):185-92. Chemical & Physical Properties Molecular Formula C16H25N3O7S Exact Mass 403.141327 PSA 165.72000 LogP 1.15430 InChIKey RXDALBZNGVATNY-CWLIKTDRSA-N |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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