CAS Number6591-63-5
SynonymsQuinidine Sulfate Dihydrate; Cinchonan-9-ol, 6'-methoxy-, (9S)-, sulfate, hydrate (2:1:2) (salt); EINECS 200-046-3; (9S)-6'-Methoxycinchonan-9-ol sulfate hydrate (2:1:2); MFCD00149346
Molecular FormulaC20H24N2O2.1/2H2O4S.H2O
Molecular Weight782.943
Purity98.00%
Boiling Point992.5ºC at 760 mmHg
Melting Point212-214 °C (dec.)(lit.)
Appearancesolid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 6591-63-5 |
| Catalog No. | 2A-9033000 |
| Chinese Name | 硫酸奎尼丁 |
| Synonyms | Quinidine Sulfate Dihydrate; Cinchonan-9-ol, 6'-methoxy-, (9S)-, sulfate, hydrate (2:1:2) (salt); EINECS 200-046-3; (9S)-6'-Methoxycinchonan-9-ol sulfate hydrate (2:1:2); MFCD00149346 |
| Molecular Formula | C20H24N2O2.1/2H2O4S.H2O |
| Molecular Weight | 782.943 |
| Purity | 98.00 |
| Boiling Point | 992.5ºC at 760 mmHg |
| Melting Point | 212-214 °C (dec.)(lit.) |
| Appearance | solid |
| Storage Condition | room temperature |
| Application | Quinidine sulfate dihydrate is a potent and selective cytochrome P450db (cytochrome P450db) inhibitor that inhibits amphetamine metabolism in the body. Quinidine sulfate dihydrate enhances vincristine |
| SMILES | C=CC1CN2CCC1CC2C(O)c1ccnc2ccc(OC)cc12.C=CC1CN2CCC1CC2C(O)c1ccnc2ccc(OC)cc12.O.O.O=S(=O)(O)O |
| InChI | InChI=1S/2C20H24N2O2.H2O4S.2H2O/c2*1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4;;/h2*3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4);2*1H2/t2*13-,14?,19+,20-;;;/m00.../s1 |
| InChI Key | ZHNFLHYOFXQIOW-AHSOWCEXSA-N |
| MSDS | msds/33000_2_6591_63_5.pdf |
| Bioactivity | Quinidine sulfate dihydrate is a potent and selective inhibitor of cytochrome P450db and inhibits amphetamine metabolism in vivo[1]. Quinidine sulfate dihydrate enhances the cytotoxicity of vincristine (VCR) in tumor cells and especially in VCR-resistant sublines of P388 leukemia (P388/VCR) and human myelogenous leukemia[2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Target IC50: cytochrome P450db; amphetamine metabolism[1] References [1]. David E. Moody, et al. Quinidine Inhibits In Vivo Metabolism of Amphetamine in Rats: Impact upon Correlation between GCIMS and Immunoassay Findings in Rat Urine. ournal of Analytical Toxicology, Vol. 14, September/October 1990 [2]. Tsuruo T, et al. Effects of quinidine and related compounds on cytotoxicity and cellular accumulation of vincristine and adriamycin in drug-resistant tumor cells.Cancer Res. 1984 Oct;44(10):4303-7. Chemical & Physical Properties Boiling Point 992.5ºC at 760 mmHg Melting Point 212-214 °C (dec.)(lit.) Molecular Formula C20H24N2O2.1/2H2O4S.H2O Molecular Weight 782.943 Flash Point 554ºC Exact Mass 782.356079 PSA 192.62000 LogP 6.52160 Index of Refraction 275 ° (C=2, 0.1mol/L HCl) InChIKey ZHNFLHYOFXQIOW-AHSOWCEXSA-N SMILES C=CC1CN2CCC1CC2C(O)c1ccnc2ccc(OC)cc12.C=CC1CN2CCC1CC2C(O)c1ccnc2ccc(OC)cc12.O.O.O=S(=O)(O)O |
| Use of | Properties Name Quinidine sulfate salt dihydrate Synonym More Synonyms Quinidine sulfate dihydrate Biological Activity Related Catalog Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 IC50: cytochrome P450db; amphetamine metabolism[1] References [1]. David E. Moody, et al. Quinidine Inhibits In Vivo Metabolism of Amphetamine in Rats: Impact upon Correlation between GCIMS and Immunoassay Findings in Rat Urine. ournal of Analytical Toxicology, Vol. 14, September/October 1990 [2]. Tsuruo T, et al. Effects of quinidine and related compounds on cytotoxicity and cellular accumulation of vincristine and adriamycin in drug-resistant tumor cells.Cancer Res. 1984 Oct;44(10):4303-7. Chemical & Physical Properties Exact Mass 782.356079 PSA 192.62000 LogP 6.52160 InChIKey ZHNFLHYOFXQIOW-AHSOWCEXSA-N |
| Transport Info | Product name: Quinidine sulfate |
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