CAS Number6384-92-5
SynonymsN-Methylaspartic acid; N-Methyl-DL-Aspartic acid; EINECS 227-012-0; DL-2-METHYLAMINOSUCCINIC ACID; N-Me-D-Asp-OH; (2R)-2-(methylamino)butanedioic acid; UNII:EU52DFC4WJ; N-Methyl--aspartic acid; MFCD06795789; N-Methyl aspartic acid; N-Methyl-D-aspartic acid
Molecular FormulaC5H9NO4
Molecular Weight147.13
Purity≥98 (TLC)%
Density1.3±0.1 g/cm3
Boiling Point258.2±30.0 °C at 760 mmHg
Melting Point189-190 °C
Appearancesolid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 6384-92-5 |
| Catalog No. | 2A-9032841 |
| Chinese Name | N-甲基-D-天冬氨酸水合物 |
| Synonyms | N-Methylaspartic acid; N-Methyl-DL-Aspartic acid; EINECS 227-012-0; DL-2-METHYLAMINOSUCCINIC ACID; N-Me-D-Asp-OH; (2R)-2-(methylamino)butanedioic acid; UNII:EU52DFC4WJ; N-Methyl--aspartic acid; MFCD06795789; N-Methyl aspartic acid; N-Methyl-D-aspartic acid |
| Molecular Formula | C5H9NO4 |
| Molecular Weight | 147.13 |
| Purity | ≥98 (TLC) |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 258.2±30.0 °C at 760 mmHg |
| Melting Point | 189-190 °C |
| Appearance | solid |
| Water Solubility | slightly soluble |
| Storage Condition | room temperature, dry |
| Application | nMDA is an agonist of the nMDA receptor and can mimic the activity of glutamate. |
| HTC | 2942000000 |
| PubChem ID | 24277987 |
| MDL Number | MFCD00004226 |
| SMILES | CN[C@H](CC(O)=O)C(O)=O |
| InChI | 1S/C5H9NO4/c1-6-3(5(9)10)2-4(7)8/h3,6H,2H2,1H3,(H,7,8)(H,9,10)/t3-/m1/s1 |
| InChI Key | HOKKHZGPKSLGJE-GSVOUGTGSA-N |
| Beilstein/REAXYS | 1724431 |
| NACRES Code | NA.32 |
| eCl@ss | 32160406 |
| UNSPSC | 12352209 |
| Hazard Symbols | transportation |
| MSDS | msds/32841_1_6384_92_5.pdf |
| Bioactivity | NMDA is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease In Vitro NMDA exerts a significant augmentation of the adrenal binding independently of the incubation temperature in a concentration-dependent manner[2]. In Vivo NMDA (0.2 nM) shows significant effects on MF, IF, IL, and EL, respectively, decreasing the mount and intromission frequencies, and shortening the intromission and ejaculation latencies. NMDA and AP-5 significantly, respectively, facilitates and inhibits the ejaculatory behavior during the copulation testing 30 min. Bilateral microinjection of NMDA into PVN significantly increases the baseline LSNA, the peaking increment of LSNA occurred within 5 min from the time of NMDA microinjected into PVN[1]. Kinase Assay Adrenal membranous homogenate suspensions are incubated with 10 nM [3H]Glu in 500/zl 50 mM Tris-acetate buffer (pH 7.4) at 2°C or 30°C in the presence and absence of various compounds. Incubation is terminated by the addition of 3 mL ice-cold buffer and subsequent filtration through a Whatman GF/B glass filter under a constant vacuum of 15 mm Hg. After washing the filter 4 times with 3 mL icecold buffer, the radioactivity trapped on the filter is measured by a liquid scintillation spectrometer using 5 mL modified Triton-toluene scintillant at a counting efficiency of 40-42%. The radioactivity found in the presence of 1 mM non-radioactive Glu is subtracted from each experimental value to obtain the specific binding of [3H]GIu in accordance with the y-aminobutyric acid (GABA) receptor binding assay system. The kinetic parameters of [3H]GIu binding, Kd and Bma x, are calculated by Scatchard analysis of the specific binding using a personal computer with a programme for non-linear regression analysis developed in our own laboratory. Animal Admin Thirty male rats are paired with different receptive females for a total of three times (once every 3 days) a week prior to the experiment, only the males that ejaculated at least three times during this period are included. After selecting the male rats with normal ejaculatory ability. Saline (100 nL), NMDA (0.20 nmol in 100 nL saline), and AP-5 (10.0 nmol in 100 nL saline) are adminitration into the bilateral PVN of each male rat in random order. After 5 min, the behavioral testing is performed and recorded as described above. Copulatory behaviors occur once a week and the entire experiment lasted 4 weeks. References [1]. Xia JD, et al. Centrally mediated ejaculatory response via sympathetic outflow in rats: role of N-methyl-D-aspartic acid receptors in paraventricular nucleus. Andrology. 2016 Nov 16. [2]. Yoneda Y, et al. Enhancement of [3H]glutamate binding by N-methyl-D-aspartic acid in rat adrenal. Brain Res. 1987 Mar 17;406(1-2):24-31. [3]. Jiang L, et al. Decrease of growth and differentiation factor 10 contributes to neuropathic pain through N-methyl-D-aspartate receptor activation. Neuroreport. 2017 May 24;28(8):444-450. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 258.2±30.0 °C at 760 mmHg Melting Point 187-192 °C Molecular Formula C5H9NO4 Molecular Weight 147.129 Flash Point 110.0±24.6 °C Exact Mass 147.053162 PSA 86.63000 LogP -0.44 Vapour Pressure 0.0±1.1 mmHg at 25°C Index of Refraction 1.494 InChIKey HOKKHZGPKSLGJE-GSVOUGTGSA-N SMILES CNC(CC(=O)O)C(=O)O Water Solubility slightly soluble |
| Use of | NMDA is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. Properties Articles331 Name N-Methyl-D-aspartic acid Synonym More Synonyms N-Methyl-D-aspartic acid Biological Activity Description NMDA is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease In Vitro NMDA exerts a significant augmentation of the adrenal binding independently of the incubation temperature in a concentration-dependent manner[2]. References [1]. Xia JD, et al. Centrally mediated ejaculatory response via sympathetic outflow in rats: role of N-methyl-D-aspartic acid receptors in paraventricular nucleus. Andrology. 2016 Nov 16. [2]. Yoneda Y, et al. Enhancement of [3H]glutamate binding by N-methyl-D-aspartic acid in rat adrenal. Brain Res. 1987 Mar 17;406(1-2):24-31. Chemical & Physical Properties Molecular Formula C5H9NO4 Exact Mass 147.053162 PSA 86.63000 LogP -0.44 Index of Refraction 1.494 InChIKey HOKKHZGPKSLGJE-GSVOUGTGSA-N SMILES CNC(CC(=O)O)C(=O)O Water Solubility slightly soluble |
| Tax Rebate | 9.0% |
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| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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