CAS Number5875-06-9
SynonymsEINECS 227-541-7; 3-amino-4-propoxybenzoate de 2-(diéthylamino)éthyle chlorhydrate; 2-(Diethylamino)ethyl-3-amino-4-propoxybenzolcarboxylathydrochlorid; Proxymetacaine Hydrochloride; Proxymetacaine Hcl; 2-(Diethylamino)ethyl 3-amino-4-propoxybenzoate hydrochloride (1:1); Benzoic acid, 3-amino-4-propoxy-, 2-(diethylamino)ethyl ester, hydrochloride (1:1); 2-(diethylamino)ethyl 3-amino-4-propoxybenzoate,hydrochloride; PROPARACAINE HCL; Proparacaine hydrochloride; MFCD00083467; 2-(diethylamino)ethyl 3-amino-4-propoxybenzoate hydrochloride; ak-taine
Molecular FormulaC16H27ClN2O3
Molecular Weight330.85
Purity98.00%
Boiling Point434.4ºC at 760mmHg
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 5875-06-9 |
| Catalog No. | 2A-9032238 |
| Chinese Name | 盐酸丙美卡因 |
| Synonyms | EINECS 227-541-7; 3-amino-4-propoxybenzoate de 2-(diéthylamino)éthyle chlorhydrate; 2-(Diethylamino)ethyl-3-amino-4-propoxybenzolcarboxylathydrochlorid; Proxymetacaine Hydrochloride; Proxymetacaine Hcl; 2-(Diethylamino)ethyl 3-amino-4-propoxybenzoate hydrochloride (1:1); Benzoic acid, 3-amino-4-propoxy-, 2-(diethylamino)ethyl ester, hydrochloride (1:1); 2-(diethylamino)ethyl 3-amino-4-propoxybenzoate,hydrochloride; PROPARACAINE HCL; Proparacaine hydrochloride; MFCD00083467; 2-(diethylamino)ethyl 3-amino-4-propoxybenzoate hydrochloride; ak-taine |
| Molecular Formula | C16H27ClN2O3 |
| Molecular Weight | 330.85 |
| Purity | 98.00 |
| Boiling Point | 434.4ºC at 760mmHg |
| Storage Condition | -20°C |
| Application | Proparacaine hydrochloride is a voltage-gated sodium channel antagonist with an ED50 of 3.4 mM. |
| PubChem ID | 329750980 |
| MDL Number | MFCD00083467 |
| SMILES | Cl.CCCOc1ccc(cc1N)C(=O)OCCN(CC)CC |
| InChI | 1S/C16H26N2O3.ClH/c1-4-10-20-15-8-7-13(12-14(15)17)16(19)21-11-9-18(5-2)6-3;/h7-8,12H,4-6,9-11,17H2,1-3H3;1H |
| InChI Key | BFUUJUGQJUTPAF-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | transportation |
| MSDS | msds/32238_1_5875_06_9.pdf |
| Bioactivity | Proparacaine Hydrochloride is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM.IC50 Value: 3.4 mM(ED50) [1]Target: Sodium Channelin vitro: Proparacaine is more potent and less toxic than cocaine [1]. Proparacaine significantly increases in FHV-1 (P < 0.01), C. felis, and 28S rDNA Ct values when fusidic acid is used [2].in vivo: Proparacaine inhibits corneal epithelial migration and adhesion through alteration of the actin cytoskeleton [3]. Proparacaine acts like bupivacaine or lidocaine and produces dose-related spinal blockades of motor function, proprioception and nociception. Intrathecal proxymetacaine also produces longer sensory blockade than motor blockade [4]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease Natural Products >> Others References [1]. Grant, R.L. and D. Acosta, Comparative toxicity of tetracaine, proparacaine and cocaine evaluated with primary cultures of rabbit corneal epithelial cells. Exp Eye Res, 1994. 58(4): p. 469-78. [2]. Segarra, S., K. Papasouliotis, and C. Helps, The in vitro effects of proxymetacaine, fluorescein, and fusidic acid on real-time PCR assays used for the diagnosis of Feline herpesvirus 1 and Chlamydophila felis infections. Vet Ophthalmol, 2011. 14 Suppl 1: [3]. Dass, B.A., H.K. Soong, and B. Lee, Effects of proparacaine on actin cytoskeleton of corneal epithelium. J Ocul Pharmacol, 1988. 4(3): p. 187-94. [4]. Hung, C.H., et al., Intrathecal oxybuprocaine and proxymetacaine produced potent and long-lasting spinal anesthesia in rats. Neurosci Lett, 2009. 454(3): p. 249-53. Chemical & Physical Properties Boiling Point 434.4ºC at 760mmHg Molecular Formula C16H27ClN2O3 Molecular Weight 330.850 Flash Point 216.5ºC Exact Mass 330.171021 PSA 64.79000 LogP 3.93940 InChIKey BFUUJUGQJUTPAF-UHFFFAOYSA-N SMILES CCCOc1ccc(C(=O)OCCN(CC)CC)cc1N.Cl Storage condition -20°C |
| Use of | Properties Articles71 Name Proxymetacaine Hydrochloride Synonym More Synonyms Proparacaine Hydrochloride Biological Activity Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease Natural Products >> Others References [1]. Grant, R.L. and D. Acosta, Comparative toxicity of tetracaine, proparacaine and cocaine evaluated with primary cultures of rabbit corneal epithelial cells. Exp Eye Res, 1994. 58(4): p. 469-78. [2]. Segarra, S., K. Papasouliotis, and C. Helps, The in vitro effects of proxymetacaine, fluorescein, and fusidic acid on real-time PCR assays used for the diagnosis of Feline herpesvirus 1 and Chlamydophila felis infections. Vet Ophthalmol, 2011. 14 Suppl 1: [3]. Dass, B.A., H.K. Soong, and B. Lee, Effects of proparacaine on actin cytoskeleton of corneal epithelium. J Ocul Pharmacol, 1988. 4(3): p. 187-94. [4]. Hung, C.H., et al., Intrathecal oxybuprocaine and proxymetacaine produced potent and long-lasting spinal anesthesia in rats. Neurosci Lett, 2009. 454(3): p. 249-53. Chemical & Physical Properties Exact Mass 330.171021 PSA 64.79000 LogP 3.93940 InChIKey BFUUJUGQJUTPAF-UHFFFAOYSA-N |
| Transport Info | Product name: Purity: 99.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip. |
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