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2-Hydroxy-1-naphthaldehyde structure, CAS 708-06-5

2-Hydroxy-1-naphthaldehyde

CAS Number708-06-5

Synonyms2-Hydroxy-1-naphthaldehyde; 2-hydroxynaphthalene-1-carboxaldehyde; 1-naphthalenecarboxaldehyde, 2-hydroxy; EINECS 211-902-0; 2-Hydroxy-naphthaldehyde; MFCD00004005; .β.-Hydroxy-.α.-naphthaldehyde

Molecular FormulaHOC10H6CHO

Molecular Weight172.18

Purity98%

Density1.3±0.1 g/cm3

Boiling Point192 °C/27 mmHg (lit.)

Melting Point76-80 °C (lit.)

Flash Point

AppearanceYellow-beige-brown powder

EINECS211-902-0

MSDSChineseEnglish

SymbolTransport

Signal WordWarning

Cat. No.: 2A-9003204 Purity: 98%
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Quality Control of [ 708-06-5 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number708-06-5
Catalog No.2A-9003204
Chinese Name2-羟基-1-萘甲醛
Synonyms2-Hydroxy-1-naphthaldehyde; 2-hydroxynaphthalene-1-carboxaldehyde; 1-naphthalenecarboxaldehyde, 2-hydroxy; EINECS 211-902-0; 2-Hydroxy-naphthaldehyde; MFCD00004005; .β.-Hydroxy-.α.-naphthaldehyde
Molecular FormulaHOC10H6CHO
Molecular Weight172.18
Purity98
Density1.3±0.1 g/cm3
Boiling Point192 °C/27 mmHg (lit.)
Melting Point76-80 °C (lit.)
AppearanceYellow-beige-brown powder
Storage ConditionStore in a sealed container in a cool, dry place.
ApplicationCFL-137 is a potent KRasG12C inhibitor. CFL-137 exhibits antiproliferative effects. CFL-137 shows anticancer activity. CFL-137 has the potential to study cancer[1].
EINECS211-902-0
HTC2912499000
PubChem ID24895523
MDL NumberMFCD00004005
SMILES[H]C(=O)c1c(O)ccc2ccccc12
InChI1S/C11H8O2/c12-7-10-9-4-2-1-3-8(9)5-6-11(10)13/h1-7,13H
InChI KeyNTCCNERMXRIPTR-UHFFFAOYSA-N
Beilstein/REAXYS742777
NACRES CodeNA.22
UNSPSC12352100
Hazard SymbolsTransport
MSDSmsds/3204_1_708_06_5.pdf
BioactivityCFL-137 is a potent KRasG12C inhibitor. CFL-137 shows an antiproliferative effect. Shows anti-proliferative effects, with IC50 values of 11.4, 24.2, 24.5, 12.3, respectively, for H1792, SW1573, MiaPaca2, H358, A549, SW480, PANC-1, LCLC-103H, BxPC3, HCA-7, MRC-5, HUVEC-TERT, and CCD-986Sk cells. 43.3, 44.5, 27.63, 32.4, 46.9, 26.2, 25.0, 10.8, 66.2 µM[1]. In Vivo CFL-137 (5 mg/kg, 5 treatments; 15 mg/kg, 5 treatments; 30 mg/kg, 3 treatments; i.p.) reduces the growth of subcutaneous human lung cancer H1792 (KRasG12C mutant) and LCLC-103H (KRasWT) mouse tumor models [1]. Animal Model: NOD/SCID female mice (KRasWT (LCLC-103H) or KRasG12C (H1792) tumors)[1] Dosage: 5 mg/kg, 5 treatments; 15 mg/kg, 5 treatments; 30 mg/kg, 3 treatments Administration: I.p. Result: Reduced tumor growth compared to the control group in KRasG12C mutated model for 32.5%. References [1]. Orgován Z, et al. Covalent fragment mapping of KRasG12C revealed novel chemotypes with in vivo potency. Eur J Med Chem. 2023 Mar 15;250:115212. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 305.8±0.0 °C at 760 mmHg Melting Point 82-85ºC Molecular Formula C11H8O2 Molecular Weight 172.18 Flash Point 134.3±13.0 °C Exact Mass 172.052429 PSA 37.30000 LogP 2.84 Vapor Pressure 0.0±0.6 mmHg at 25°C Index of Refraction 1.719 InChIKey NTCCNERMXRIPTR-UHFFFAOYSA-N SMILES O=Cc1c(O)ccc2ccccc12
Use ofProperties Articles25 Name 2-Hydroxy-1-naphthaldehyde Synonym More Synonyms 2-Hydroxy-naphthaldehyde Biological Activity Related Catalog Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Ras In Vitro CFL-137 (72 h) showed anti-proliferative effects against H1792, SW1573, MiaPaca2, H358, The IC50 values of A549, SW480, PANC-1, LCLC-103H, BxPC3, HCA-7, MRC-5, HUVEC-TERT, and CCD-986Sk cells were 11.4, 24.2, 24.5, 12.3, 43.3, 44.5, 27.63, 32.4, 46.9, respectively. 26.2, 25.0, 10.8, 66.2 µM[1]. References Chemical & Physical Properties Molecular Formula C11H8O2 Exact Mass 172.052429 PSA 37.30000 Index of Refraction 1.719 InChIKey NTCCNERMXRIPTR-UHFFFAOYSA-N
Tax Rebate9.0%
SupervisionNone. MFN tariff: 5.5%. Ordinary tariff: 30.0%
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Danger Regulations: 3077 International Maritime Transport Danger Regulations: 3077 International Air Transport Danger Regulations: 3077 14.2 United Nations shipping name European land transport hazard regulations: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (2-Hydroxy-1- naphthaldehyde) IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (2-Hydroxy-1- naphthaldehyde) International air transport hazard regulations: Environmentally hazardous substance, solid, n.o.s. (2-Hydroxy-1-naphthaldehyde) 14.3 Transport hazard categories European land transport Dangerous Regulations: 9 International sea transport Dangerous Regulations: 9 International air transport Dangerous Regulations: 9 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Dangerous Regulations: Yes International Maritime Transport Dangerous Regulations International Air Transport Dangerous Regulations: Yes Marine Pollutants (Yes/No): Yes 14.6 Special reminder to users further information Dangerous goods are individually packaged, with liquids exceeding 5 liters or solids exceeding 5 kilograms. The outer packaging of each independent package and the combined independent inner package must have EHS on it. Identification (according to European ADR Regulation 2.2.9.1.10, IMDG Regulation 2.10.3),
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