CAS Number700-49-2
Synonyms2-fluoro-adenin; 2-FLUORO-6-AMINOPURINE; 2-fluoro-9H-purin-6-amine; 2-Fluoroadenine; 6-AMINO-2-FLUOROPURINE; TCMDC-124283; MFCD01632749; 2-fluoropurine; 2-fluoroadenibe; 2-Fluoro-1H-purin-6-amine; 2-fad; 6-amino-2-fluoro-purin; BUTTPARK 25 1-01; 2-fluoradenine; 2-fluoro-1h-purin-6-amin
Molecular FormulaC5H4FN5
Molecular Weight153.12
Purity96%
Density1.7±0.1 g/cm3
Boiling Point676.9±58.0 °C at 760 mmHg
Melting Point>350 °C (lit.)
AppearanceWhite to light yellow crystal powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 700-49-2 |
| Catalog No. | 2A-9003164 |
| Chinese Name | 2-氟腺嘌呤 |
| Synonyms | 2-fluoro-adenin; 2-FLUORO-6-AMINOPURINE; 2-fluoro-9H-purin-6-amine; 2-Fluoroadenine; 6-AMINO-2-FLUOROPURINE; TCMDC-124283; MFCD01632749; 2-fluoropurine; 2-fluoroadenibe; 2-Fluoro-1H-purin-6-amine; 2-fad; 6-amino-2-fluoro-purin; BUTTPARK 25 1-01; 2-fluoradenine; 2-fluoro-1h-purin-6-amin |
| Molecular Formula | C5H4FN5 |
| Molecular Weight | 153.12 |
| Purity | 96 |
| Density | 1.7±0.1 g/cm3 |
| Boiling Point | 676.9±58.0 °C at 760 mmHg |
| Melting Point | >350 °C (lit.) |
| Appearance | White to light yellow crystal powder |
| Storage Condition | Room temperature, avoid light, ventilated and dry |
| Application | 2-Fluoroadenine is a toxic purine base. 2-Fluoroadenine is toxic to non-proliferating and proliferating tumor cells. 2-Fluoroadenine can be used to study anticancer drugs [1]. |
| HTC | 2933990090 |
| PubChem ID | 24878071 |
| MDL Number | MFCD01632749 |
| SMILES | Nc1[nH]c(F)nc2ncnc12 |
| InChI | 1S/C5H4FN5/c6-5-10-3(7)2-4(11-5)9-1-8-2/h1H,(H3,7,8,9,10,11) |
| InChI Key | WKMPTBDYDNUJLF-UHFFFAOYSA-N |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| MSDS | msds/3164_1_700_49_2.pdf |
| Bioactivity | 2-Fluoroadenine is a toxic purine bases. 2-Fluoroadenine has toxicity in nonproliferating and proliferating tumor cells. 2-Fluoroadenine can be used for researching anticancer[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Target DNA/RNA synthesis[1] In Vitro 2-Fluoroadenine (2 μM; 4 hours) inhibits CEM cell growth by targeting one or more enzymes involved in either RNA or protein synthesis[1]. 2-Fluoroadenine (0-1000 μM; 96 hours) exhibits cytotoxicity in nonproliferating MRC-5 cells[1]. 2-Fluoroadenine (0.22, 2.2 and 22 μM; 30 hours) inhibits protein, RNA, and DNA syntheses in Balb-3T3 cells incubated in serum-free medium[1]. Cell Proliferation Assay Cell Line: CEM cells[1] Concentration: 2 μM Incubation Time: 4 hours Result: Inhibited CEM cell growth by targeting one or more enzymes involved in either RNA or protein synthesis. Cell Cytotoxicity Assay Cell Line: MRC-5 cells[1] Concentration: 0-1000 μM Incubation Time: 4 hours Result: Exhibited cytotoxicity in nonproliferating MRC-5 cells. References [1]. Parker WB, et al. Metabolism and metabolic actions of 6-methylpurine and 2-fluoroadenine in human cells. Biochem Pharmacol. 1998;55(10):1673-1681. Chemical & Physical Properties Density 1.7±0.1 g/cm3 Boiling Point 676.9±58.0 °C at 760 mmHg Melting Point >350 °C(lit.) Molecular Formula C5H4FN5 Molecular Weight 153.12 Flash Point 363.2±32.3 °C Exact Mass 153.045074 PSA 80.48000 LogP -0.01 Vapour Pressure 0.0±2.1 mmHg at 25°C Index of Refraction 1.783 InChIKey WKMPTBDYDNUJLF-UHFFFAOYSA-N SMILES Nc1nc(F)nc2nc[nH]c12 Storage condition Refrigerator |
| Use of | 2-Fluoroadenine is a toxic purine bases. 2-Fluoroadenine has toxicity in nonproliferating and proliferating tumor cells. 2-Fluoroadenine can be used for researching anticancer[1]. Properties Articles17 Name 2-fluoroadenine Synonym More Synonyms TCMDC-124283 Biological Activity Description 2-Fluoroadenine is a toxic purine bases. 2-Fluoroadenine has toxicity in nonproliferating and proliferating tumor cells. 2-Fluoroadenine can be used for researching anticancer[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis DNA/RNA synthesis[1] References [1]. Parker WB, et al. Metabolism and metabolic actions of 6-methylpurine and 2-fluoroadenine in human cells. Biochem Pharmacol. 1998;55(10):1673-1681. Chemical & Physical Properties Molecular Formula C5H4FN5 Exact Mass 153.045074 PSA 80.48000 LogP -0.01 Index of Refraction 1.783 InChIKey WKMPTBDYDNUJLF-UHFFFAOYSA-N SMILES Nc1nc(F)nc2nc[nH]c12 Storage condition Refrigerator |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 0.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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